BMC Research Notes

http://link.springer.com/journal/13104

List of Papers (Total 6,571)

Development of microsatellite loci for two New World vultures (Cathartidae)

ObjectiveUse next-generation sequencing to develop microsatellite loci that will provide the variability necessary for studies of genetic diversity and population connectivity of two New World vulture species.ResultsWe characterized 11 microsatellite loci for black vultures (Coragyps atratus) and 14 loci for turkey vultures (Cathartes aura). These microsatellite loci were grouped...

Eggshell membrane protein can be absorbed and utilised in the bodies of rats

ObjectiveEggshell membranes, the thin film lining the insides of eggshells, are constituted mostly from protein (eggshell membrane protein, ESM-P). The digestibility and dietary net protein utility of ESM-P are not known. ESM-P functions as a barrier to prevent foreign matter from reaching the egg white and yolk, so it would be expected not to decompose easily by digestion when...

Prevalence and risk factors of pneumococcal nasopharyngeal carriage in healthy children attending kindergarten, in district of Arsi Zone, South East, Ethiopia

ObjectiveS. pneumoniae responsible for a range of respiratory infections from uncomplicated to severe invasive pneumococcal disease. Nasopharyngeal specimens were collected from children attending kindergarten and aged ≤ 6 years from February, 2017 to June, 2017 to assess the nasopharyngeal carriage and antimicrobial susceptibility pattern of S. pneumoniae. Parents of children...

Incomplete childhood vaccination and associated factors among children aged 12–23 months in Gondar city administration, Northwest, Ethiopia 2018

ObjectiveDespite the fact that immunization services are offered free of charge in Ethiopia but the coverage of complete vaccination is still low. The aim of the study is to determine incomplete vaccination and associated factors among children aged 12–23 months in Gondar city administration, Northwest Ethiopia, 2018.ResultThe proportion of incomplete vaccination among children...

Place for elective cholecystectomy for patients with severe thalassaemia: a retrospective case control study

ObjectiveAt present, cholecystectomy is carried out for thalassaemia patients with gall stone disease only if they develop symptoms of cholecystitis, except in the rare instance where an un-inflammed gall bladder is removed simultaneously with splenectomy. We carried out this retrospective analysis of case records to examine if patients with thalassaemia have a higher rate of...

Retrotransposon expression in response to in vitro inoculation with two fungal pathogens of Scots pine (Pinus sylvestris L.)

ObjectiveConifer genomes show high genetic diversity in intergenic regions that contain diverse sets of transposable elements with dominating long terminal repeat (LTR) retrotransposons (RE). Transcription of RE in response to environmental stimuli could produce various types of regulatory non-coding RNAs, but global genomic methylation changes could result in a coincidental...

Neonatal deaths in Cambodia: findings from a community-based mortality review

ObjectivesThe aim of this study was to describe potential factors contributing to neonatal mortality in Takeo, Cambodia through assessment of verbal autopsies collected following newborn deaths in the community. The mortality review was nested within a trial of a behavioral intervention to improve newborn survival, and was conducted after the close of the trial, within the study...

Mebendazole-induced M1 polarisation of THP-1 macrophages may involve DYRK1B inhibition

ObjectiveWe recently showed that the anti-helminthic compound mebendazole (MBZ) has immunomodulating activity by inducing a M2 to M1 phenotype switch in monocyte/macrophage models. In the present study we investigated the potential role of protein kinases in mediating this effect.ResultsMBZ potently binds and inhibits Dual specificity tyrosine-phosphorylation-regulated kinase 1B...

Predictors associated with HIV/AIDS patients dropout from antiretroviral therapy at Mettu Karl Hospital, southwest Ethiopia

ObjectiveThe aim of this study was to determine the major risk factors of antiretroviral therapy dropout. The retrospective cohort research design was applied. 1512 HIV patients were included from Mettu Karl Hospital in Illubabor Zone, southwest part of Ethiopia from September 2005 to January 2018. Kaplan–Meier comparison and log-logistic regression accelerated failure time model...

The trials and tribulations of conducting an m-health pilot randomized controlled trial to improve oral cancer therapy adherence: recommendations for future multisite, non-drug clinical trials

ObjectiveIntegrating mobile phone-based health (m-health) interventions into healthcare systems is one solution to improve access to services for the growing number of patients with chronic illness. Practical challenges such as poor recruitment and inadequate resource allocation can hamper the assessment of such interventions with clinical trial methodology. This paper highlights...

Effect of Peer Assisted Learning (PAL) education on knowledge, attitude and behavior related to prevention and control of diabetes

ObjectivesThe present study aimed to compare the effect of Peer Assisted Learning (PAL) method and routine lecture on knowledge, attitudes, and behaviors of participants in the prevention of diabetes.ResultsThe results showed that one month after the intervention and the implementation of the educational program, the mean scores of the two groups in terms of knowledge, attitude...

Zero-valent iron sand filtration reduces concentrations of virus-like particles and modifies virome community composition in reclaimed water used for agricultural irrigation

ObjectiveZero-valent iron sand filtration can remove multiple contaminants, including some types of pathogenic bacteria, from contaminated water. However, its efficacy at removing complex viral populations, such as those found in reclaimed water used for agricultural irrigation, has not been fully evaluated. Therefore, this study utilized metagenomic sequencing and epifluorescent...

A human specific Alu DNA cassette is found flanking the genes of transcription factor AP2

ObjectiveAlu elements are retroposons that invaded the primate genome and shaped its biology. Some Alus inserted recently and are polymorphic in the human population. It is these Alus that are being sought after in disease association studies and regulatory biology. Discovering polymorphic Alus in the human genome can open areas of new research in these fields.ResultsUsing the...

Prospective cohort of adult oral health in Piracicaba, SP, Brazil

ObjectiveTo describe the methodological aspects of a Prospective Cohort Study of adult oral health in Piracicaba, Brazil.ResultsThis Prospective Cohort Study evaluated adults (20–64 years old) between the years of 2011 and 2015, in Piracicaba, São Paulo, Brazil. The main objective was to evaluate the risk factors for tooth loss in adults. Data were collected at households and...

An OpenMP-based tool for finding longest common subsequence in bioinformatics

ObjectiveFinding the longest common subsequence (LCS) among sequences is NP-hard. This is an important problem in bioinformatics for DNA sequence alignment and pattern discovery. In this research, we propose new CPU-based parallel implementations that can provide significant advantages in terms of execution times, monetary cost, and pervasiveness in finding LCS of DNA sequences...

Bacillus subtilis RarA forms damage-inducible foci that scan the entire cell

ObjectivesLittle is known about the activity and dynamics of ATPase RarA in B. subtilis, proposed to act at stalled DNA replication forks due to DNA damage. We performed fluorescence microscopy time lapse experiments with a functional RarA-mVenus fusion to visualize the dynamics of RarA during conditions that generate DNA damage.Data descriptionIn exponentially growing cells, we...

Tobacco use and caries increment in young adults: a prospective observational study

ObjectiveTobacco use has a negative influence on general and oral health but data concerning caries are mainly derived from epidemiological and cross-sectional studies. The aim of this study was to investigate smoking and use of smokeless tobacco (Swedish snus) as determinants of dental caries increment in young adults over 3 years. The baseline cohort consisted of 1295 19-year...

Effects of vitamin D3 and its chemical analogs on the growth of Hodgkin’s lymphoma, in vitro

ObjectiveVitamin D receptor (VDR) activities have been noted for a number of B cell malignancies which showed varying sensitivities to vitamin D3 (1,25-dihydroxyvitamin D3, VD3, calcitriol) and its synthetic analogs. The objective of this study was to address the potential effects of VD3 and vitamin D3 analogs (VDAs) on the growth of Hodgkin’s lymphoma (HL), a malignant pathology...

Appropriate complementary feeding practice and associated factors among mothers having children aged 6–24 months in Debre Tabor Hospital, North West Ethiopia, 2016

ObjectiveThis study was aimed to assess appropriate complementary feeding practice and associated factors among mothers having children aged 6–24 months in Debre Tabor Hospital, North West Ethiopia, 2016.ResultsIn this study, 37.2% of mothers had appropriate complementary feeding practice. Mothers’ level of education above grade 12 (AOR = 2.96, CI 1.2–7.62), husbands’ occupation...

Work motivation and its effects on organizational performance: the case of nurses in Hawassa public and private hospitals: Mixed method study approach

ObjectiveThe main objective of the study was to assess level of motivation, how nurses perceived work motivation and its effects on organizational performance among nurses working in Hawassa public and private hospitals.ResultsIt was found that majority (64.1%) of the nurses perceived motivation as motivators. Getting prospective encouragement, recognition and financial...

Erectile dysfunction and associated factors among men with diabetes mellitus from a tertiary diabetic center in Northern Sri Lanka

ObjectivePrevalence of erectile dysfunction (ED) in diabetic men is considerably high but it is often underdiagnosed and undermanaged. There were no data available about the prevalence and the risk factors of ED in our region. So a cross-sectional study was conducted to identify the prevalence and associated risk factors of ED in a tertiary care diabetic center in Northern Sri...

Schistosoma mansoni infection among preschool age children attending Erer Health Center, Ethiopia and the response rate to praziquantel

ObjectivePreschool age children (PSAC) are excluded from community based praziquantel treatment programs mainly due to paucity of evidence on the magnitude of schistosomiasis, efficacy and safety of this treatment in PSAC. The aim of this study is to assess Schistosoma mansoni infection rate and evaluate response to praziquantel in PSAC. A facility based longitudinal study was...

Correlating physical activity and quality of life of healthcare workers

ObjectiveThe purpose of the present study was to investigate healthcare workers’ physical exercise levels linked to their quality of life. Healthcare workers’ from all departments of a General hospital participated in the study. The instruments used for data collection regarding quality of life and physical exercise (Short Form Health Survey (SF-36) and International Physical...

Attitude of Nursing and Midwifery students towards clinical practice and its associated factors in Northwest Ethiopia: a cross-sectional study

ObjectiveThe aim of this study was to assess the attitude of Nursing and Midwifery students towards clinical practice and its associated factors at University of Gondar, Northwest Ethiopia. 2018.ResultThe prevalence of a favorable attitude towards clinical practice was found to be 42.9% in this study. The odds of having favorable attitude were found to be 2 times higher among...

Preliminary study on the expression of endothelial cell biology related genes in the liver of dengue virus infected mice treated with Carica papaya leaf juice

ObjectiveThe purpose of this study was to profile and identify the endothelial cell biology related genes that are affected by dengue virus infection in the liver tissue of AG129 mice, with and without Carica papaya leaf juice treatment.ResultsThe dengue fever mouse model was established by intraperitoneal inoculation of dengue virus, New Guinea C strain at 2 × 106 PFU. Daily...