BMC Research Notes

http://link.springer.com/journal/13104

List of Papers (Total 6,571)

Evaluation of therapeutic effects of FAK inhibition in murine models of atherosclerosis

ObjectiveTherapeutic effects of focal adhesion kinase (FAK) inhibition using a small molecule inhibitor was evaluated in apolipoprotein E (apoE) knockout (KO) and low-density lipoprotein receptor (LDLr) KO mouse atherosclerosis models.ResultsThe prevention trial consisted of an 8-week treatment with an FAK inhibitor concurrent treatment with a high fat (HF)/high cholesterol (HC...

A genetical metabolomics approach for bioprospecting plant biosynthetic gene clusters

ObjectivePlants produce a plethora of specialized metabolites to defend themselves against pathogens and insects, to attract pollinators and to communicate with other organisms. Many of these are also applied in the clinic and in agriculture. Genes encoding the enzymes that drive the biosynthesis of these metabolites are sometimes physically grouped on the chromosome, in regions...

Association of bullying experiences with depressive symptoms and psychosocial functioning among school going children and adolescents

ObjectivesWe examined the association of bullying experiences with depressive symptoms and psychosocial functioning among children and adolescents in rural Pakistan. A total of 452 school-going children in Nawabshah, Pakistan were conveniently interviewed to assess rates of bullying experiences and severity of depressive symptoms. Depressive symptoms were assessed using the...

Prevalence of glucose-6-phosphate dehydrogenase deficiency in Cameroonian blood donors

ObjectiveDeficiency in G6PD is the most common enzymopathy worldwide. It is frequently found in individuals of African descent in whom it can lead to hemolytic crises triggered by the use of certain antimalarial medications and infection. The prevalence of G6PD deficiency and its contribution to morbidity in West Africa is under-studied. To understand the prevalence of glucose-6...

Clinical presentation and hematological profile among young and old chronic lymphocytic leukemia patients in Sudan

ObjectiveTo assess the clinical presentation and hematological profile among young (≤ 55 years) and old (> 55 years) chronic lymphocytic leukemia patients in Sudan.ResultIn the present cross-sectional descriptive study, out of 110 cases studied, among them 31 (28.2%) were young (≤ 55 years) patients with mean age 48 years, and 79 (71.8%) were elder patients (> 55 years) with mean...

Diagnostic accuracy of ultrasound characteristics in the identification of malignant thyroid nodules

ObjectiveThis study was aimed at determining the diagnostic accuracy of the ultrasound characteristics in the identification of malignant thyroid nodules in patients attending the surgical clinic at a tertiary care hospital in Sri Lanka.ResultsThis prospective validation study was conducted among 263 patients attending the surgical clinic at a tertiary care hospital, Sri Lanka...

Unexpected insertion of carrier DNA sequences into the fission yeast genome during CRISPR–Cas9 mediated gene deletion

ObjectivesThe fission yeast Schizosaccharomyces pombe is predicted to encode ~ 200 proteins of < 100 amino acids, including a number of previously uncharacterised proteins that are found conserved in related Schizosaccharomyces species only. To begin an investigation of the function of four of these so-called microproteins (designated Smp1–Smp4), CRISPR–Cas9 genome editing...

Sickness-related absenteeism and risk factors associated among flower farm industry workers in Bishoftu town, Southeast Ethiopia, 2018: a cross-sectional study

ObjectiveThe objective of this study was to investigate prevalence and factors affecting sickness absenteeism among flower farm industry workers in Bishoftu town, Ethiopia. A workplace-based cross-sectional study was conducted from March to April 2018. A sample of 444 participants were included using a stratified sampling technique. We performed binary logistic regression...

Ribosomal/nucleolar stress induction regulates tert-Butyl hydroperoxide (tBHP) mediated oxidative stress in Anopheles gambiae midguts

ObjectiveA fundamental understanding of redox homeostasis in Anopheles gambiae midgut cells under different oxidative conditions is missing. Such knowledge can aid in the development of new malaria transmission-blocking strategies aimed at disrupting natural homeostatic processes in the mosquito during Plasmodium parasite uptake (i.e. blood feeding). The aim of this study was to...

Intestinal parasitic infections among public and private schoolchildren of Kathmandu, Nepal: prevalence and associated risk factors

ObjectiveIntestinal parasitic infections (IPIs) are a major cause of morbidity among children in developing countries. Investigation about the etiological agents and socio-ecological pattern of the infection would help to design better preventive strategy. The previous studies reported high prevalence of IPIs among schoolchildren of Nepal. Though these data may be essential for...

Patterns of road traffic injury and potential consequences among patients visiting Hawassa University Comprehensive Specialized Hospital, Hawassa, Ethiopia

ObjectiveRoad traffic injury (RTI) is the leading cause of death among aged 15–29 years, although low and middle income countries only have half of the vehicles, they have 80% of road traffic related death. This study aimed to assess the probability of road traffic injury occurrence and potential consequences among patient visiting at emergency department of Hawassa University...

Knowledge and practice on adequate sunlight exposure of infants among mothers attending EPI unit of Aleta Wondo Health Center, SNNPR, Ethiopia

ObjectiveThe main objective of this study was to assess knowledge and practice of adequate sunlight exposure of infants among mothers attending EPI unit at Aleta Wondo Health Center, Sidama zone, SNNPR, Ethiopia. Institutional based descriptive cross sectional study design was used. 313 mothers who had under 1 year child and immunization follow-up were selected by simple random...

Novel binding partners for Prenylated Rab Acceptor 1 identified by a split-ubiquitin yeast two-hybrid screen

ObjectivePrenylated Rab Acceptor 1 (PRA1) is a transmembrane protein localized to the early secretory pathway. It has been found to interact with an array of Rab GTPases, leading to its hypothesized function in the recycling of Rab GTPases. However, all previous strategies used to screen for novel interacting partners have utilized a classic yeast two-hybrid approach that...

Suicidal ideation and suicide attempts in subjects aged 15–19 in Lomé (Togo)

ObjectivesThe purpose of this study was to study the epidemiological and clinical profile of adolescents with suicidal thoughts, with or without suicide attempts, and to identify associated factors.ResultsA total of 155 (16.5%) of the 941 adolescents interviewed had suicidal thoughts. The average age of the respondents was 18 ± 2.1 years. The sex ratio (m/f) was 1.4. With regard...

Virulence of a T6SS Campylobacter jejuni chicken isolate from North Romania

ObjectivesIn this study we have investigated the in vitro and in vivo virulence characteristics of a new T6SS positive Campylobacter jejuni chicken isolate (SV12) originating from a poultry population in North Romania. A detailed phenotypic characterization was performed and compared to the T6SS negative C. jejuni 81–176 wild strain.ResultsOur results indicate that the...

Cross-cultural adaptation and validation of the Indonesian version of AQUAREL on patients with permanent pacemaker: a cross-sectional study

ObjectiveThe assessment of quality of life has significant impact in device therapy. This research was aimed to translate and evaluate the validity and reliability of the Indonesian version of the AQUAREL questionnaire.ResultsWe evaluated 32 patients during the cross-cultural adaptation stage and 20 patients during validity and reliability evaluation stages. Indonesian version of...

Factors associated with knowledge on obstetric danger signs among women who gave birth within 1 year in Bahir Dar city administration, North West, Ethiopia

ObjectiveThis study aimed to assess factors associated with knowledge on obstetric danger signs among women who gave birth within 1 year in North West, Ethiopia.ResultsOverall, 37.9% of the respondents were knowledgeable. Women mention three and more key danger signs during pregnancy and after delivery were 15% and 18.5% respectively. Decision making power of women [AOR = 1.59...

Medication non-adherence and associated factors among diabetes patients in Felege Hiwot Referral Hospital, Bahir Dar city administration, Northwest Ethiopia

ObjectiveThis study was aimed to assess medication non-adherence and associated factors among adult diabetes in Felege Hiwot Referral Hospital Bahir Dar city administration. To overcome this object, a cross-sectional study was conducted among 416 randomly selected diabetes patients at the Felege Hiwot Referral Hospital (FHRH). Eight item Morisky Medication Adherence Scale...

Mutagenesis of seed storage protein genes in Soybean using CRISPR/Cas9

ObjectiveSoybean seeds are an important source of vegetable proteins for both food and industry worldwide. Conglycinins (7S) and glycinins (11S), which are two major families of storage proteins encoded by a small family of genes, account for about 70% of total soy seed protein. Mutant alleles of these genes are often necessary in certain breeding programs, as the relative...

Two-third of inmates were depressed among HIV positive prisoners at central prison (Kaliti), Addis Ababa, Ethiopia

ObjectiveDepression is the most frequently observed psychiatric disorder among HIV positives and it is becoming worse in prisoners. The aim this study was to assess prevalence and associated factors of depression among HIV positive prisoners at central prison (Kaliti) Addis Ababa.ResultThe prevalence of depression was found to be 66.5% (95% CI 62, 71). Primary education [AOR = 4...

Differential genome-wide DNA methylation patterns in childhood obesity

ObjectiveExposure to stress during pregnancy may program susceptibility to the development of obesity in offspring. Our goal was to determine whether prenatal maternal stress (PNMS) due to a natural disaster was associated with child obesity, and to compare the DNA methylation profiles in obese versus non-obese children at age 13½ years. Women and their children were involved in...

Application of a partial cell recycling chemostat for continuous production of aroma compounds at near-zero growth rates

ObjectiveThe partial cell recycling chemostat is a modification of the chemostat in which cells are partially recycled towards the bioreactor. This allows using dilution rates higher than the maximum growth rate resulting in higher biomass concentrations and increased process rates. In this study, we demonstrate with a single observation that this system can also be used to study...

A proposal for a self-rated frailty index and status for patient-oriented research

ObjectiveFrailty indices are important predictors of major health outcomes, but mostly designed by and for researchers and specialists. Three of the most commonly used theory-based indices are composite measures that are subject to arbitrary assumptions and biases introduced due to data processing. A complicated index can be simplified with fewer items. The theory-based frailty...

Bacterial contaminants of stored blood and blood components ready for transfusion at blood banks in Mekelle, Northern Ethiopia

ObjectiveBacterial contamination of donated blood and blood components is a major public health problem globally. The aim of the study was to evaluate the rate and spectrum of bacterial contaminations and antimicrobial susceptibility pattern of contaminants in stored blood and blood components.ResultsA total of 196 blood and blood components (concentrated red blood cells, fresh...

No detection of EBV, BKV and JCV in breast cancer tissue samples in Iran

ObjectiveThe most common cancer amongst women is breast cancer. Reports on the role of EBV, BKV, and JCV in the development of breast cancer are controversial. Hence, the aim of this study was to determine the frequency of EBV, BKV, and JCV in malignant breast tumors in comparison with benign ones.ResultsA total of 300 breast biopsy tissues were included, of which 150 were...