BMC Research Notes

http://link.springer.com/journal/13104

List of Papers (Total 6,424)

Genome sequence of the brown rot fungal pathogen Monilinia fructigena

ObjectivesMonilinia fructigena (phylum Ascomycota, family Sclerotiniaceae) is a plant pathogen that causes brown rot and blossom blight in pome fruit and stone fruit of the Rosaceae family, which can cause significant losses in the field and mainly postharvest. The aim of this study was to create a high-quality draft of the M. fructigena genome assembly and annotation that...

Observations of playground play during elementary school recess

ObjectiveThe purpose of the current study was to examine reliability and validity evidence for an observational measure of playground play during recess. Observational data of what children played at recess were collected at 236 recess sessions across 26 urban elementary schools. An inductive content analysis of children’s type of play and activity engagement during recess was...

Genome-wide map of human and mouse transcription factor binding sites aggregated from ChIP-Seq data

ObjectivesMammalian genomics studies, especially those focusing on transcriptional regulation, require information on genomic locations of regulatory regions, particularly, transcription factor (TF) binding sites. There are plenty of published ChIP-Seq data on in vivo binding of transcription factors in different cell types and conditions. However, handling of thousands of...

Youth sports activity and young people’s well-being after a disaster: a trial with the Mastery Approach to Coaching (MAC) in the Philippines

ObjectiveSports activities is broadly utilized to support well-being of youth after a disaster or conflict. However, scientific validation of programs have not been conducted. The Mastery Approach to Coaching (MAC) is a coaching-education program on sports activities. The MAC reported to have a positive effect on youngsters’ self-esteem. As self-esteem is generally known to be...

Visual biofeedback training reduces quantitative drugs index scores associated with fall risk

ObjectiveDrugs increase fall risk and decrease performance on balance and mobility tests. Conversely, whether biofeedback training to reduce fall risk also decreases scores on a published drug-based fall risk index has not been documented. Forty-eight community-dwelling older adults underwent either treadmill gait training plus visual feedback (+VFB), or walked on a treadmill...

High-fat, high-sugar diet induces splenomegaly that is ameliorated with exercise and genistein treatment

ObjectiveWe tested the effect of exercise training and genistein treatment on splenomegaly in mice fed a high-fat, high-sugar diet (HFSD).ResultsMale and female C57BL6 mice fed HFSD containing 60% fat along with drinking water containing 42 g/L sugar (55% sucrose/45% fructose) for 12 weeks exhibited significant obesity, hyperglycemia, and elevated plasma IL-6 levels. This was...

Health care seeking behaviour of mothers towards diarrheal disease of children less than 5 years in Mekelle city, North Ethiopia

ObjectiveTo assess the health care seeking behavior of mothers on diarrheal disease of under five children and associated factors in Mekelle City, Northern Ethiopia.ResultThis study revealed that 72.5% (n = 58) of the mothers who reported their children had diarrhea had sought health care facilities. Three quarter, (75.9%) of them was seeking health in the public health care...

The effectiveness of internet-delivered cognitive behavioural therapy for those with bulimic symptoms: a systematic review

ObjectiveThis review looked at internet-delivered cognitive behavioural therapy (iCBT) as a possible treatment for patients with bulimic symptoms. CBT has been established as an effective treatment; however, waiting lists lead to delayed initiation of treatment. iCBT is a possible delivery method to combat this. Medline, EMBASE and PsycInfo were searched for controlled trials...

Production of a mono-biotinylated EGFR nanobody in the E. coli periplasm using the pET22b vector

ObjectiveOur aim was to produce a mono-biotinylated single domain antibody (‘nanobody’) specific for the epidermal growth factor receptor (EGFR), which is overexpressed in many cancer cells. The binding of the nanobody and its function are tested in cancer cells. The construct could be used to carry variable therapeutic or diagnostic load using biotin-streptavidin bridging...

High report of miscarriage among women living with HIV who want to conceive in Uganda

ObjectiveData on early miscarriage incidence is limited due to various social and methodological barriers. We report on 24-month pregnancy outcomes of 299 female Ugandan HIV clients in committed relationships with an intention to conceive. Miscarriage data are reported as auxiliary findings to a larger study (5R01HD072633).Results127 (42%) participants reported a pregnancy during...

Incidence of tuberculosis in children on antiretroviral therapy: a retrospective cohort study

ObjectivesBe aware of the burden of tuberculosis among high-risk population is important. Three hundred fifty-two children were participated in this study. Survival analysis was conducted. We assessed the incidence of tuberculosis and its predictors in children on ART.ResultsTuberculosis incidence rate in children on ART was 2.63 per 100 person-years. Those children who were on...

Comparison of a new wrist-worn accelerometer with a commonly used triaxial accelerometer under free-living conditions

ObjectiveThe Life Microscope is a new wristband-based life recorder system that can identify various human movements. We aimed to compare physical activity data captured using the Life Microscope with data from a commonly used accelerometer.ResultsTwenty-nine participants (34.6 ± 12.5 years) wore both the Life Microscope and an Active Style Pro accelerometer for 7 days. Physical...

Exploring the role of obesity and overweight in predicting postoperative outcome of abdominal surgery in a sub-Saharan African setting: a prospective cohort study

ObjectiveCurrent literature on the role of excess weight in predicting surgical outcome is controversial. In sub-Saharan Africa, there is extreme paucity of data regarding this issue in spite of the increasing rates of obesity and overweight in the region. This prospective cohort study, carried out over a period of 4 months at Limbe Regional Hospital in the Southwest region of...

Nigella sativa as an anti-inflammatory agent in asthma

ObjectiveNigella sativa (N. sativa) has several pharmacological actions which include antioxidant, antidiabetic, anticancer, antitussive, immunomodulator, analgesic, antimicrobial, anti-inflammatory, spasmolytic, and bronchodilator. The purpose of this study is to measure the effectivity of N. sativa ethanol extract as anti-inflammation on peritoneal Wistar rat mast cells. The...

Health care providers’ adherence to immediate postpartum care guideline and associated factors among women who gave birth in Mekele public teaching hospitals, Tigray 2018

ObjectiveTo assess health care providers adherence to immediate postpartum care and associated factors among women’s who gave birth in Mekele teaching public hospitals, 2018.ResultsThe Health care providers’ complete adherence to immediate postpartum care guideline was 22.8%. Health care providers who have complete adherence to prenatal care guideline were 93.3% less likely to...

The impact of expectancy on cognitive performance during alcohol hangover

ObjectiveKnowing the purpose of a clinical study may provoke expectancies among subjects that may influence the study outcome. For example, expectancies about a drug effect may cause subjects to put in more effort to counteract these effects on performance tasks, or cause stress or other mood alterations in anticipation of expected adverse effects. The objective of this study was...

Two-thirds of pregnant women attending antenatal care clinic at the University of Gondar Hospital are found with subclinical iodine deficiency, 2017

ObjectiveThis study was aimed at determining the magnitude of prenatal iodine deficiency and its determinants among women attending antenatal care clinic at the University of Gondar Specialized Referral Hospital, Northwest Ethiopia. A cross-sectional study was conducted from March 13 to April 25/2017. Precisely, 378 pregnant women were included in the study selected via...

Between-year vocal aging in female red deer (Cervus elaphus)

ObjectivesStudying animal vocal aging has potential implication in the field of animal welfare and for modeling human voice aging. The objective was to examine, using a repeated measures approach, the between-year changes of weight, social discomfort score (bites of other hinds on hind pelt), body condition score (fat reserves) and acoustic variables of the nasal (closed-mouth...

Healing rates in diabetes-related foot ulcers using low frequency ultrasonic debridement versus non-surgical sharps debridement: a randomised controlled trial

ObjectiveCurrent clinical practice varies around debridement techniques used to promote healing of diabetes-related foot ulcers. This randomised controlled study will compare healing rates for diabetes-related foot ulcers treated with low frequency ultrasonic debridement versus non-surgical sharps debridement. Individuals with diabetes-related foot ulcers being managed by...

Plexin domain containing 2 (PLXDC2) gene polymorphism rs7081455 may not influence POAG risk in a Saudi cohort

ObjectivePlexin domain containing 2 (PLXDC2), a cell surface transmembrane protein receptor for pigment epithelium derived factor, is expressed in many tissues including the eye. Polymorphism rs7081455 flanking PLXDC2 has been associated with primary open angle glaucoma (POAG) and its clinical phenotypes and may have a role in POAG. Rs7081455 was genotyped in POAG cases (n = 188...

Knowledge and practice of iodized salt utilization among reproductive women in Addis Ababa City

ObjectiveThe objective of this study was to assess knowledge and practice of iodized salt utilization among reproductive women in Addis Ababa city. A cross-sectional study was carried out on 549 households. A sample district was designated by using the simple random sampling techniques. Data were collected by a face-to-face interview and household salt was tested to check whether...

The burden of stroke in Brazil in 2016: an analysis of the Global Burden of Disease study findings

ObjectiveTo analyze the epidemiological stroke data of Brazil according to the Global Burden of Disease (GBD) study in 2016 and secondary data from the GBD database.ResultsThe highest percentage of deaths due to stroke in general occurred in individuals aged 70 years or over (60.2%; 95% confidence interval [CI] 59.9–60.5%) followed by that in men (52.9%; 95% CI 52.6–53.2...

Genetic diversity and chemical variability of Lippia spp. (Verbenaceae)

BackgroundThe genus Lippia comprises 150 species, most of which have interesting medicinal properties. Lippia sidoides (syn. L. origanoides) exhibits strong antimicrobial activity and is included in the phytotherapy program implemented by the Brazilian Ministry of Health. Since species of Lippia are morphologically very similar, conventional taxonomic methods are sometimes...

Novel codons in rat Pdx-1 complementary DNA

ObjectivesPancreatic and duodenal homeobox-1 (Pdx-1) is a homeodomain-containing transcription factor essential for pancreatic development, beta-cell differentiation and the maintenance of mature beta cell function. To transfect the expression vectors of Pdx-1 in the mammalian cells, the complementary DNA (cDNA) of Pdx-1 was conducted.ResultsNovel codons and amino acids sequences...

Factors associated with rapidly repeated acute poisoning by substances of abuse: a prospective observational cohort study

ObjectiveWe have previously found that 9% of patients treated for acute poisoning by substances of abuse in a primary care emergency outpatient setting presented with a new poisoning within a week. We now identify factors associated with rapidly repeated acute poisoning by substances of abuse.ResultsIn 169/1952 (9%) cases of acute poisoning by substances of abuse included...