PLOS ONE

http://journals.plos.org/plosone/

List of Papers (Total 202,518)

Trends and future of maternal and child health in Bangladesh

Background Maternal and child health is one of the most important issues in a developing country like Bangladesh. This study evaluates the trends in maternal and child health indicators of Bangladesh. Methods The secondary data used in this study was extracted from the World Bank Dataset. The selected indicators were maternal mortality ratio (MMR), under-five children mortality...

Molecular modeling simulation studies reveal new potential inhibitors against HPV E6 protein

High-risk strains of human papillomavirus (HPV) have been identified as the etiologic agent of some anogenital tract, head, and neck cancers. Although prophylactic HPV vaccines have been approved; it is still necessary a drug-based treatment against the infection and its oncogenic effects. The E6 oncoprotein is one of the most studied therapeutic targets of HPV, it has been...

Transcriptome response of roots to salt stress in a salinity-tolerant bread wheat cultivar

Salt stress is one of the major adverse environmental factors limiting crop productivity. Considering Iran as one of the bread wheat origins, we sequenced root transcriptome of an Iranian salt tolerant cultivar, Arg, under salt stress to extend our knowledge of the molecular basis of salinity tolerance in Triticum aestivum. RNA sequencing resulted in more than 113 million reads...

Long-term dietary intervention with low Phe and/or a specific nutrient combination improve certain aspects of brain functioning in phenylketonuria (PKU)

Introduction In phenylketonuria (PKU), a gene mutation in the phenylalanine metabolic pathway causes accumulation of phenylalanine (Phe) in blood and brain. Although early introduction of a Phe-restricted diet can prevent severe symptoms from developing, patients who are diagnosed and treated early still experience deficits in cognitive functioning indicating shortcomings of...

Definition of apical descent in women with and without previous hysterectomy: A retrospective analysis

Background While normal pelvic organ support has been defined for women with intact uterus, this is not the case for post- hysterectomy vault descent. A recent systematic review found that definitions of apical prolapse are highly variable. Objectives To investigate the relationship between prolapse symptoms and apical POP-Q measurements and establish cutoffs for ‘significant...

RUPEE: A fast and accurate purely geometric protein structure search

Given the close relationship between protein structure and function, protein structure searches have long played an established role in bioinformatics. Despite their maturity, existing protein structure searches either use simplifying assumptions or compromise between fast response times and quality of results. These limitations can prevent the easy and efficient exploration of...

Family caregiver satisfaction with inpatient rehabilitation care

Introduction Informal family caregivers play an increasingly important role in healthcare. Despite their role in ongoing management and coordination of care, caregiver satisfaction with the healthcare services care recipients receive has been understudied. We sought to assess what influences caregiver satisfaction with inpatient care provided to their care recipient among...

The intracellular Ca2+ concentration is elevated in cardiomyocytes differentiated from hiPSCs derived from a Duchenne muscular dystrophy patient

Duchenne muscular dystrophy (DMD) is the most common and severe form of muscular dystrophy. The major symptoms of this condition are walking difficulties, dyspnea caused by progressive skeletal muscle weakness, and cardiomyopathy. Recent advances in ventilator support devices have dramatically decreased mortality caused by respiratory distress. Consequently, cardiomyopathy...

Could long-term overhead load in painters be associated with rotator cuff lesions? A pilot study

Background Use of the arm above shoulder level has been described as a risk factor for developing rotator cuff tears (RCT). There is a lack of information regarding the frequency and distribution of RCT in a population using their arms above shoulder level during daily work. The aim of this study was to analyze clinical and radiographic findings in a population of painters...

Automated multi-sample acquisition and analysis using atomic force microscopy for biomedical applications

In the last 20 years, atomic force microscopy (AFM) has emerged as a ubiquitous technique in biological research, allowing the analysis of biological samples under near-physiological conditions from single molecules to living cells. Despite its growing use, the low process throughput remains a major drawback. Here, we propose a solution validated on a device allowing a fully...

Mindfulness, rumination, and coping skills in young women with Eating Disorders: A comparative study with healthy controls

Eating Disorders (ED) have been associated with dysfunctional coping strategies, such as rumination. Promoting alternative ways of experiencing mental events, based on a mindfulness approach, might be the clue for learning more effective coping and regulatory strategies among young women with ED. This study examined the comparison between patients with ED diagnosis and healthy...

Pneumonia-associated death in patients with dementia: A systematic review and meta-analysis

Background Pneumonia is a serious disease associated with mortality among patients with dementia. However, the reported frequency of pneumonia as a cause of death in patients with dementia varies, the reason for which has not been fully elucidated. Methods We conducted a systematic search in PubMed and the Cochrane Database of Systematic Reviews (inception to December 2016). Two...

Recurrent palaeo-wildfires in a Cisuralian coal seam: A palaeobotanical view on high-inertinite coals from the Lower Permian of the Paraná Basin, Brazil

Distribution and abundance of charcoal in coal seams (in form of pyrogenic macerals of the inertinites group) have been considered as a reliable tool to interpret the local and regional palaeo-wildfire regimes in peat-forming depositional environments. Although the occurrence of inertinites is globally well documented for the Late Palaeozoic, the description of palaeobotanical...

Opportunities for genomic selection in American mink: A simulation study

Genomic selection can be considered as an effective tool for developing breeding programs in American mink. However, the genetic gains for economically important traits can be influenced by the accuracy of genomic predictions. The objective of this study was to investigate the prediction accuracies of traditional best linear unbiased prediction (BLUP), multi-step genomic BLUP...

ERBB2-modulated ATG4B and autophagic cell death in human ARPE19 during oxidative stress

Age-related macular degeneration (AMD) is an ocular disease with retinal degeneration. Retinal pigment epithelium (RPE) degeneration is mainly caused by long-term oxidative stress. Kinase activity could be either protective or detrimental to cells during oxidative stress; however, few reports have described the role of kinases in oxidative stress. In this study, high-throughput...

Improving preterm newborn identification in low-resource settings with machine learning

Background Globally, preterm birth is the leading cause of neonatal death with estimated prevalence and associated mortality highest in low- and middle-income countries (LMICs). Accurate identification of preterm infants is important at the individual level for appropriate clinical intervention as well as at the population level for informed policy decisions and resource...

Multispectral imaging and unmanned aerial systems for cotton plant phenotyping

This paper demonstrates the application of aerial multispectral images in cotton plant phenotyping. Four phenotypic traits (plant height, canopy cover, vegetation index, and flower) were measured from multispectral images captured by a multispectral camera on an unmanned aerial system. Data were collected on eight different days from two fields. Ortho-mosaic and digital elevation...

Fluorescent reporter assays provide direct, accurate, quantitative measurements of MGMT status in human cells

The DNA repair protein O6-methylguanine DNA methyltransferase (MGMT) strongly influences the effectiveness of cancer treatment with chemotherapeutic alkylating agents, and MGMT status in cancer cells could potentially contribute to tailored therapies for individual patients. However, the promoter methylation and immunohistochemical assays presently used for measuring MGMT in...

Development and validation of Yatt Suicide Attitude Scale (YSAS) in Malaysia

Introduction Despite suicide rate becoming a growing trend in research locally and globally, there is no standard measuring instrument developed in Malaysia. The aim of this study is to establish the first ever Malay version of suicide screening tool that is suitable and fit with multiracial and complex culture of Malaysia. Methods This study comprises of three phases, namely (1...

A computational scheme for internal models not requiring precise system parameters

Utilization by humans of a precise and adaptable internal model of the dynamics of the body in generating movements is a well-supported concept. The prevailing opinion is that such an internal model ceaselessly develops through long-term repetition and accumulation in the central nervous system (CNS). However, a long-term learning process would not be absolutely necessary for the...

Length of stay following cesarean sections: A population based study in the Friuli Venezia Giulia region (North-Eastern Italy), 2005-2015

Background Births by cesarean section (CS) usually require longer recovery time, and as a result women remain hospitalized longer following CS than vaginal delivery (VD). A number of strategies have been proposed to reduce avoidable health care costs associated with childbirth. Among these, the containment of length of hospital stay (LoS) has been identified as an important...

Objective measurement of tummy time in infants (0-6 months): A validation study

The 2017 Australian and Canadian 24-hour movement guidelines recommend infants receive 30 minutes of tummy time daily. Currently, there are no validated objective measurement tools or devices to assess tummy time. The purpose of this study was to: 1) test the practicality of using devices on infants as an objective measure of tummy time, and 2) test the accuracy of developed...

Trends in global shark attacks

Shark attacks are a global phenomenon that attracts widespread attention and publicity, often with negative outcomes for shark populations. Despite the widespread perceptions of shark attacks, trends in human water activities and shark populations are both dynamic, resulting in variable rates of shark attacks over space and time. Understanding variable trends in shark attacks may...