European Radiology

https://link.springer.com/journal/330

List of Papers (Total 824)

Ferumoxytol magnetic resonance angiography: a dose-finding study in patients with chronic kidney disease

ObjectivesFerumoxytol is an alternative to gadolinium-based compounds as a vascular contrast agent for magnetic resonance angiography (MRA), particularly for patients with chronic kidney disease (CKD). However, dose-related efficacy data are lacking. We aimed to determine the optimal (minimum effective) dose of ferumoxytol for MRA in patients with CKD.MethodsFerumoxytol-enhanced...

T2 mapping of the meniscus is a biomarker for early osteoarthritis

PurposeTo evaluate in vivo T2 mapping as quantitative, imaging-based biomarker for meniscal degeneration in humans, by studying the correlation between T2 relaxation time and degree of histological degeneration as reference standard.MethodsIn this prospective validation study, 13 menisci from seven patients with radiographic knee osteoarthritis (median age 67 years, three males...

Comparison between dynamic gadoxetate-enhanced MRI and 99mTc-mebrofenin hepatobiliary scintigraphy with SPECT for quantitative assessment of liver function

ObjectivesTo compare Gd-EOB-DTPA dynamic hepatocyte-specific contrast-enhanced MRI (DHCE-MRI) with 99mTc-mebrofenin hepatobiliary scintigraphy (HBS) as quantitative liver function tests for the preoperative assessment of patients undergoing liver resection.MethodsPatients undergoing liver surgery and preoperative assessment of future remnant liver (FRL) function using 99mTc...

Artificial intelligence in radiology: who’s afraid of the big bad wolf?

This Editorial comment refers to the article “Medical students’ attitude towards artificial intelligence: a multicenter survey,” Pinto Dos Santos D, et al Eur Radiol 2018.Key Points • Medical students are not well informed of the potential consequences of AI in radiology. • The fundamental principles of AI—as well as its application in medicine—must be taught in medical schools...

Gender-specific association of body composition with inflammatory and adipose-related markers in healthy elderly Europeans from the NU-AGE study

ObjectivesThe aim of this work was to examine the cross-sectional relationship between body composition (BC) markers for adipose and lean tissue and bone mass, and a wide range of specific inflammatory and adipose-related markers in healthy elderly Europeans.MethodsA whole-body dual-energy X-ray absorptiometry (DXA) scan was made in 1121 healthy (65–79 years) women and men from...

Multi-parametric and multi-regional histogram analysis of MRI: modality integration reveals imaging phenotypes of glioblastoma

ObjectivesIntegrating multiple imaging modalities is crucial for MRI data interpretation. The purpose of this study is to determine whether a previously proposed multi-view approach can effectively integrate the histogram features from multi-parametric MRI and whether the selected features can offer incremental prognostic values over clinical variables.MethodsEighty newly...

Normative volume measurements of the fetal intra-cranial compartments using 3D volume in utero MR imaging

PurposeTo describe the normal linear measurements of the skull (bi-parietal diameter and occipito-frontal diameter) and intracranial volumes (ventricular volume, brain parenchymal volume, extra-axial volume and total intra-cranial volume) in normal fetuses.Materials and methodsWe recruited pregnant women from low-risk pregnancies whose fetuses had normal ultrasound and in utero...

Automated 3D segmentation and diameter measurement of the thoracic aorta on non-contrast enhanced CT

ObjectivesTo develop and evaluate a fully automatic method to measure diameters of the ascending and descending aorta on non-ECG-gated, non-contrast computed tomography (CT) scans.Material and methodsThe method combines multi-atlas registration to obtain seed points, aorta centerline extraction, and an optimal surface segmentation approach to extract the aorta surface around the...

A rapid high-performance semi-automated tool to measure total kidney volume from MRI in autosomal dominant polycystic kidney disease

ObjectivesTo develop a high-performance, rapid semi-automated method (Sheffield TKV Tool) for measuring total kidney volume (TKV) from magnetic resonance images (MRI) in patients with autosomal dominant polycystic kidney disease (ADPKD).MethodsTKV was initially measured in 61 patients with ADPKD using the Sheffield TKV Tool and its performance compared to manual segmentation and...

Disk injury in patients with vertebral fractures—a prospective diagnostic accuracy study using dual-energy computed tomography

ObjectivesUsing magnetic resonance imaging (MRI) as the standard of reference, we aimed to evaluate the diagnostic accuracy of dual-energy computed tomography (DECT) in assessing disk injuries in patients aged more than 50 years with vertebral fractures.MethodsThis prospective study was approved by the local ethics committee (EA1/372/14), and all patients gave written informed...

MR extracellular volume mapping and non-contrast T1ρ mapping allow early detection of myocardial fibrosis in diabetic monkeys

ObjectiveTo detect diffuse myocardial fibrosis in different severity levels of left ventricular diastolic dysfunction (DD) in spontaneous type 2 diabetes mellitus (T2DM) rhesus monkeys.MethodsEighteen spontaneous T2DM and nine healthy monkeys were studied. Echocardiography was performed for diastolic function classification. Cardiac magnetic resonance (CMR) imaging was performed...

Impact of guidelines for the management of minor head injury on the utilization and diagnostic yield of CT over two decades, using natural language processing in a large dataset

ObjectivesWe investigated the impact of clinical guidelines for the management of minor head injury on utilization and diagnostic yield of head CT over two decades.MethodsRetrospective before-after study using multiple electronic health record data sources. Natural language processing algorithms were developed to rapidly extract indication, Glasgow Coma Scale, and CT outcome from...

Dynamic [18F]FET-PET/MRI using standard MRI-based attenuation correction methods

AimTo assess if tumour grading based on dynamic [18F]FET positron emission tomography/magnetic resonance imaging (PET/MRI) studies is affected by different MRI-based attenuation correction (AC) methods.MethodsTwenty-four patients with suspected brain tumours underwent dynamic [18F]FET-PET/MRI examinations and subsequent low-dose computed tomography (CT) scans of the head. The...

Citations in scientific articles: possibly biased reflections on the field of diagnostic imaging

This Editorial Comment refers to the article “Citation Bias in Imaging Research: Are studies with higher diagnostic accuracy estimates cited more often?” by Frank RA, Sharifabadi AD, Salameh JP et al, Eur Radiol. 2018 Nov 15.  https://doi.org/10.1007/s00330-018-5801-8 [1].

Predictive value of pretreatment MRI texture analysis in patients with primary nasopharyngeal carcinoma

ObjectivesTo determine the predictive value of pretreatment MRI texture analysis for progression-free survival (PFS) in patients with primary nasopharyngeal carcinoma (NPC).MethodsEthical approval by the institutional review board was obtained for this retrospective analysis. In 79 patients with primary NPC, texture analysis of the primary tumour was performed on pretreatment T2...

Is the Greulich and Pyle atlas applicable to all ethnicities? A systematic review and meta-analysis

ObjectiveTo determine whether the Greulich and Pyle (G&P) atlas is applicable when applied to populations of different ethnicity.MethodsA systematic review of studies published between 1959 and 15th February 2017 identified from the Embase, MEDLINE and Cochrane databases was undertaken. Quality of the studies was assessed using the National Institute for Health and Care...

Evaluation of pressure-controlled mammography compression paddles with respect to force-controlled compression paddles in clinical practice

ObjectivesTo reduce pain and discomfort associated with breast compression in mammography, a pressure-controlled compression paddle was recently introduced.The objective was to evaluate the pressure-controlled paddle by comparing it to the standard force-controlled paddle.MethodsDifferences of compressed breast thickness (CBT), compression force, compression pressure, and average...

An alternative approach to contrast-enhanced imaging: diffusion-weighted imaging and T1-weighted imaging identifies and quantifies necrosis in Wilms tumour

ObjectivesVolume of necrosis in Wilms tumour is informative of chemotherapy response. Contrast-enhanced T1-weighted MRI (T1w) provides a measure of necrosis using gadolinium. This study aimed to develop a non-invasive method of identifying non-enhancing (necrotic) tissue in Wilms tumour.MethodsIn this single centre, retrospective study, post-chemotherapy MRI data from 34 Wilms...

Time-series hyperpolarized xenon-129 MRI of lobar lung ventilation of COPD in comparison to V/Q-SPECT/CT and CT

PurposeTo derive lobar ventilation in patients with chronic obstructive pulmonary disease (COPD) using a rapid time-series hyperpolarized xenon-129 (HPX) magnetic resonance imaging (MRI) technique and compare this to ventilation/perfusion single-photon emission computed tomography (V/Q-SPECT), correlating the results with high-resolution computed tomography (CT) and pulmonary...

Prognosis-based definition of left ventricular remodeling after ST-elevation myocardial infarction

ObjectivesCardiac magnetic resonance (CMR) is the gold-standard modality for the assessment of left ventricular (LV) remodeling in ST-elevation myocardial infarction (STEMI) patients. However, the commonly used remodeling criteria have never been validated for hard clinical events. We therefore aimed to define clear CMR criteria of LV remodeling following STEMI with proven...