Current Geriatrics Reports

http://link.springer.com/journal/13670

List of Papers (Total 72)

Update on Interventions to Prevent or Reduce Frailty in Community-Dwelling Older Adults: a Scoping Review and Community Translation

Purpose of ReviewWith increasing interest in frailty prevention and management globally, this scoping review provides an update to the current knowledge on interventions to reduce frailty in community-dwelling older adults and its state of translation in real-world settings.Recent FindingsUpdating previous findings of 14 studies from 2000 to 2016 by Puts et al., we reviewed 10...

Consequences of Inadequate Intakes of Vitamin A, Vitamin B12, Vitamin D, Calcium, Iron, and Folate in Older Persons

Purpose of ReviewThis review broadly discusses the consequences of inadequate consumption, by deficit or excess, of selected micronutrients on the quality of life and morbidity during aging, specifically considering increases in life expectancy and the costs of care in the older persons.Recent FindingsA literature review of the periods 2012 to 2018, focusing on vitamins A, B12...

Correction to: Management of Osteoporotic and Neuropathic Ankle Fractures in the Elderly

The original version of this article unfortunately contained an incorrect version of authors’ names and surnames (underlined) for Dr. C.J.A. Van Bergen and Dr. M.P.J. Van den Bekerom.

Primary Endocrine Therapy in Older Women with Breast Cancer

Purpose of ReviewBreast cancer incidence increases with age. In recent years, primary endocrine therapy has been increasingly used as a treatment option for frail elderly women with breast cancer, although surgery is still the guideline-recommended treatment. In this review, we discuss the evidence for primary endocrine therapy versus surgical treatment in older women with early...

Management of Osteoporotic and Neuropathic Ankle Fractures in the Elderly

Purpose of ReviewTreatment of osteoporotic and neuropathic ankle fractures in the elderly is challenging. The purpose of this paper is to review recent publications on this topic and to identify the optimal treatment for these fractures.Recent FindingsTreatment consists of a variety of conservative or operative options all with advantages and disadvantages as described in this...

Chronic Subdural Haematoma in the Elderly: Is It Time for a New Paradigm in Management?

Chronic subdural haematoma (CSDH) is a common neurological condition that usually affects the elderly. The optimal treatment strategy remains uncertain, principally because there is a lack of a good evidence base. In this paper, we review the literature concerning the peri-operative and operative care of patients. In particular, we highlight the non-surgical aspects of care that...

The Crossroads of Geriatric Cardiology and Cardio-Oncology

Cancer and cardiovascular disease (CVD) are two major causes of mortality in older adults. With improved survival and outcomes from cancer and CVD, the role of the geriatrician is evolving. Geriatricians provide key skills to facilitate patient-centered and value-based care in the growing older population of cancer patients (and survivors). Cancer treatment in older adults is...

Update on Disease-Modifying/Preventive Therapies in Alzheimer’s Disease

Alzheimer’s disease (AD) is increasingly becoming a major health problem throughout the US and Western Europe. As the remnants of the Baby Boom generation begin to reach their seniority at the turn of the twenty-first century, the disease has been unwillingly brought to the attention of the public eye. A disease that has traditionally been associated with an aging population has...

Caloric Restriction to Moderate Senescence: Mechanisms and Clinical Utility

As life expectancy in the United States continues to increase, the maintenance of independence among older Americans has emerged as a major clinical and public health priority. Therefore, there is an urgent need to identify interventions that can maintain or enhance cognitive and physical function with the goal of preventing or delaying the onset of disability. To date, caloric...

Cardiac Hegemony of Senescence

Cardiac senescence and age-related disease development have gained general attention and recognition in the past decades due to increased accessibility and quality of health care. The advancement in global civilization is complementary to concerns regarding population aging and development of chronic degenerative diseases. Cardiac degeneration has been rigorously studied. The...

Mechanisms of Cardiovascular Aging

Aging is a major driver of cardiovascular (CV) disease. Incidence of stroke and myocardial infarction increases, and is associated with worsening outcomes, in relation to patient age. Therefore, by studying chronological age in relation to other CV risk factors, pertinent mechanisms of senescence and disease in the heart and blood vessels can be delineated. This is a rather...

Interventions to Improve Walking in Older Adults

Interventions to improve walking in older adults have historically been multifactorial (i.e., strengthening, endurance and flexibility programs) focusing on improving the underlying impairments. These impairment-based programs have resulted in only modest improvements in walking. In older adults, walking is slow, less stable, inefficient, and the timing and coordination of...

Cardiovascular Calcifications in Old Age: Mechanisms and Clinical Implications

Vascular calcification, a hallmark of aging, is accelerated in patients with hypertension, diabetes, and chronic kidney disease. It may be viewed as the result of disturbances of the complex and subtle balance between inhibitors and promoters, acting at both the systemic and local levels. Ethnic differences in certain components of the atherosclerosis process were identified...

Functions and Mechanisms of Arginase in Age-Associated Cardiovascular Diseases

Advanced age is a prominent risk factor of cardiovascular and metabolic diseases, such as atherosclerosis and type II diabetes. The underlying mechanisms are complex and not fully understood. Recent studies provide accumulating evidence demonstrating a potential role of arginases including arginase-I and arginase-II, the isoenzymes involved in L-arginine metabolism, in...

Assessment of Gait, Balance, and Mobility in Older Adults: Considerations for Clinicians

Accurate assessment of gait, balance, and mobility in older adults is an important aspect of clinical practice for clinicians working with this population. This report presents evidence regarding assessment in each of these domains. Outcome measures were selected for inclusion if recent evidence (publication within previous 18 months) regarding their properties was available in...

Impact and Management of MRSA in the Long-Term Care Setting

Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of morbidity and mortality in healthcare facilities. Residents of nursing homes are commonly colonized with MRSA and acquisition within these facilities is common. While treatment of MRSA infection in the NH is more costly than treatment of infections caused by methicillin-susceptible strains, the frequency of...

Emergence and Control of Antibiotic-resistant Gram-negative Bacilli in Older Adults

The prevalence of multidrug resistant Gram-negative organisms is increasing worldwide. The Infectious Diseases Society of America has previously singled out groups of pathogens with the highest threat, the majority of which are Gram-negative bacilli. These isolates are prevalent not only in intensive-care units of acute-care facilities, but are also found among residents of long...

Treatment of Alzheimer’s Disease: Current Management and Experimental Therapeutics

Alzheimer’s disease (AD) is a major cause of morbidity in the elderly. AD affects over 5 million persons in the United States, but because it increases in incidence in the elderly, and because of the “graying” of the population, AD is projected to increase in prevalence by many-fold over the coming decades. AD causes progressive mental impairment, resulting in the inability of...

Primary Central Nervous System Tumors in the Aging Population

The incidence of primary brain tumors peaks in the aging population, and advanced age in often a prognostic factor associated with shorter survival. In the United States, it is estimated that 69,720 individuals will be diagnosed with primary CNS tumors in 2013, of which 24,560 are expected to be malignant and 45,160 non-malignant. Approximately 50 % of primary CNS tumors are...

Relationship of Gait and Cognition in the Elderly

Gait and cognitive impairments in older adults mostly reflect the co-occurrence of two geriatric syndromes linked by common underlying brain substrates and pathologies. Gait control is predominately mediated by frontal subcortical circuits, which overlap with circuits controlling executive control and attention functions. These circuits are vulnerable to multiple age-related...

Vascular Dementia

The purpose of this review is to highlight existing literature on the epidemiology, pathophysiology, and novel risk factors for vascular dementia. We further examine the evidence linking chronic brain hypoperfusion induced by a variety of cardiovascular diseases to the development of vascular dementia. In the elderly, in whom cerebral perfusion is diminished by the aging process...

Changing Epidemiology and Control of Clostridium difficile in Older Adults

Clostridium difficile infection (CDI) presents unique clinical challenges among older adults. Older patients tend to have more severe disease, more treatment failures, and higher rates of relapse. As the burden of CDI in older adults continues to grow, better paradigms for the prevention and treatment of CDI in this vulnerable population will be essential. In this review, we...

Issues in the Diagnosis and Management of Urinary Tract Infections in the Older Adult

Urinary tract infection is a common problem of elderly populations. Clinical trials addressing urinary infection in the elderly frequently use nonstandardized diagnostic criteria, which compromises the validity of conclusions. Studies of prevention of infection in postmenopausal women in the community consistently report outcomes similar to observations in premenopausal women...

Self-management of Function in Older Adults: The Contribution of Physical Therapy

The increase in chronic disease and associated musculoskeletal impairment experienced by a rising number of older persons will contribute to a surge in the prevalence of disability globally. The prevention of functional decline and the challenge of maintaining optimal functioning is complex and understudied. This review explores how physical therapy principles are applied within...