Drug Design, Development and Therapy

https://www.dovepress.com/drug-design-development-and-therapy-archive19

List of Papers (Total 1,383)

Efficacy of neoadjuvant platinum-based chemotherapy during the second and third trimester of pregnancy in women with cervical cancer: an updated systematic review and meta-analysis

Efficacy of neoadjuvant platinum-based chemotherapy during the second and third trimester of pregnancy in women with cervical cancer: an updated systematic review and meta-analysis Yizuo Song, Yi Liu, Min Lin, Bo Sheng, Xueqiong Zhu Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China Purpose: To evaluate the...

Combination of rifaximin and lactulose improves clinical efficacy and mortality in patients with hepatic encephalopathy

Combination of rifaximin and lactulose improves clinical efficacy and mortality in patients with hepatic encephalopathy Zhida Wang,1 Pei Chu,2 Wenjin Wang2 1Comprehensive Clinical Skill Training Center, The First Hospital of Lanzhou University, Lanzhou 730030, China; 2Department of Emergency, The First Hospital of Lanzhou University, Lanzhou 730030, China Background: Rifaximin...

Topical anesthesia therapy using lidocaine-loaded nanostructured lipid carriers: tocopheryl polyethylene glycol 1000 succinate-modified transdermal delivery system

Topical anesthesia therapy using lidocaine-loaded nanostructured lipid carriers: tocopheryl polyethylene glycol 1000 succinate-modified transdermal delivery system Xiangju Zhao, Ying Sun, Zhaoguo Li Department of Anesthesiology, Affiliated Hospital of Jining Medical University, Jining, Shandong 272000, People’s Republic of China Purpose: Transdermal drug delivery of local...

Gamma linolic acid regulates PHD2 mediated hypoxia and mitochondrial apoptosis in DEN induced Hepatocellular carcinoma

Gamma linolic acid regulates PHD2 mediated hypoxia and mitochondrial apoptosis in DEN induced Hepatocellular carcinoma Hong Cui,1 Feng Han,1 Ling Zhang,1 Li Wang,1 Mukesh Kumar2 1Department of Hepatobiliary and Pancreatic Surgery, The Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou City, Henan Province 450008, China; 2Chandra Shekhar Singh College of Pharmacy...

ADAR1 silencing-induced HUVEC apoptosis is mediated by FGFR2 under hypoxia stress

ADAR1 silencing-induced HUVEC apoptosis is mediated by FGFR2 under hypoxia stress Yun Jiang,1 Zhancheng Wang,1 Xu Chen,1 Wei Wang,1 Xiaowei Wang2 1Department of Cardiology, The Eighth People’s Hospital of Shanghai, Shanghai 200233, China; 2Shanghai Weiang Info Tech Ltd., Shanghai 200233, China Background: The adenosine deaminase acting on RNA 1 (ADAR1) specifically deaminates...

Inhibition of ROS-mediated activation Src-MAPK/AKT signaling by orientin alleviates H2O2-induced apoptosis in PC12 cells

Inhibition of ROS-mediated activation Src-MAPK/AKT signaling by orientin alleviates H2O2-induced apoptosis in PC12 cells Shimei Qi,1,2,* Zunyong Feng,1,3,* Qiang Li,1,2 Zhilin Qi,1,2 Yao Zhang1,2 1Anhui Province Key Laboratory of Active Biological Macro-molecules, Wannan Medical College, Wuhu 241002, People’s Republic of China; 2Department of Biochemistry, Wannan Medical College...

CTL019 (tisagenlecleucel): CAR-T therapy for relapsed and refractory B-cell acute lymphoblastic leukemia

CTL019 (tisagenlecleucel): CAR-T therapy for relapsed and refractory B-cell acute lymphoblastic leukemia Stephanie Vairy,* Julia Lopes Garcia,* Pierre Teira, Henrique Bittencourt Division of Haematology and Oncology, Department of Pediatrics, CHU Sainte-Justine, Université de Montréal, Montréal, QC, Canada *These authors contributed equally to this work Abstract: Over the past...

Two-drug regimens for treatment of naïve HIV-1 infection and as maintenance therapy

Two-drug regimens for treatment of naive HIV-1 infection and as maintenance therapy Katya C Corado, Margaret R Caplan, Eric S Daar Department of Medicine, Division of HIV Medicine, David Geffen School of Medicine at UCLA, Harbor-UCLA Medical Center, Torrance, CA, USA Abstract: As people live longer with HIV infection, there has been a resurgence of interest in challenging the use...

Efficacy and safety of Tongfu powder in acute pancreatitis patients with gastrointestinal dysfunction: a clinical trial

Efficacy and safety of Tongfu powder in acute pancreatitis patients with gastrointestinal dysfunction: a clinical trial Bin Miao, Feng-Wu Li, Shu-Wen Zhang, Hong Wang, Wen-Jie Qi, Chao Wang Department of Infectious Disease, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China Objective: To evaluate the efficacy and safety of Tongfu powder...

Saponins enhance exon skipping of 2′-O-methyl phosphorothioate oligonucleotide in vitro and in vivo

Saponins enhance exon skipping of 2'-O-methyl phosphorothioate oligonucleotide in vitro and in vivo Mingxing Wang, Bo Wu, Sapana N Shah, Peijuan Lu, Qilong Lu McColl-Lockwood Laboratory for Muscular Dystrophy Research, Department of Neurology, Cannon Research Center, Carolinas Medical Center, Charlotte, NC 28203, USA Background: Antisense oligonucleotide (ASO)-mediated exon...

Asiatic acid ameliorates CC l4-induced liver fibrosis in rats: involvement of Nrf2/ARE, NF-κB/IκBα, and JAK1/STAT3 signaling pathways

Asiatic acid ameliorates CC l4-induced liver fibrosis in rats: involvement of Nrf2/ARE, NF-κB/IκBα, and JAK1/STAT3 signaling pathways Jie Fan,1,* Qingshan Chen,2,* Liwen Wei,1 Xiaoming Zhou,3 Rong Wang,4 Hai Zhang1 1Department of Pharmacy, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 201204, China; 2Department of Pharmacy, Shanghai...

Combination of Ginsenoside Rg1 and Astragaloside IV reduces oxidative stress and inhibits TGF-β1/Smads signaling cascade on renal fibrosis in rats with diabetic nephropathy

Combination of Ginsenoside Rg1 and Astragaloside IV reduces oxidative stress and inhibits TGF-beta1/Smads signaling cascade on renal fibrosis in rats with diabetic nephropathy Na Du, Zhiping Xu, Mingyue Gao, Peng Liu, Bo Sun, Xia Cao Department of Pharmacology, Jilin University, Jilin, Changchun, China Introduction: Anti-oxidative stress and inhibition of TGF-β1/Smads signaling...

Shensong Yangxin capsule reduces atrial fibrillation susceptibility by inhibiting atrial fibrosis in rats with post-myocardial infarction heart failure

Shensong Yangxin capsule reduces atrial fibrillation susceptibility by inhibiting atrial fibrosis in rats with post-myocardial infarction heart failure Jin Ma,1,* Chunxia Yin,1,* Shiyu Ma,2 Huiliang Qiu,1 Chaoyang Zheng,1 Qiuxiong Chen,1 Chunhua Ding,1,3 Weihui Lv1 1Heart Center, Guangdong Provincial Hospital of Chinese Medicine, 2nd Affiliated Hospital of Guangzhou University of...

Inhibition of sialidase activity as a therapeutic approach

Inhibition of sialidase activity as a therapeutic approach Victor Yu Glanz,1 Veronika A Myasoedova,2 Andrey V Grechko,3 Alexander N Orekhov2,4 1Department of Genetics, Cytology and Bioengineering, Faculty of Biology and Medicine, Voronezh State University, Voronezh, Russia; 2Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Moscow, Russia; 3Federal...

Immediate release tablet formulation of varenicline salicylate and comparative pharmacokinetic study in human volunteers

Immediate release tablet formulation of varenicline salicylate and comparative pharmacokinetic study in human volunteers Seong Shin Kwak,1,* Eun Seok Lee,1,* Ho Yub Yoon,1 Chang Hyun Kim,1 Yoon Tae Goo,1 Myung Joo Kang,2 Sangkil Lee,3 Bong Sang Lee,4 Hong Ryeol Jeon,4 Chang Hyun Oh,5 Young Wook Choi1 1College of Pharmacy, Chung-Ang University, Heuksuk-ro, Dongjak-gu, Seoul 06974...

α-hemihydrate calcium sulfate/octacalcium phosphate combined with sodium hyaluronate promotes bone marrow-derived mesenchymal stem cell osteogenesis in vitro and in vivo

α-hemihydrate calcium sulfate/octacalcium phosphate combined with sodium hyaluronate promotes bone marrow-derived mesenchymal stem cell osteogenesis in vitro and in vivo Changshun Chen,1 Chen Zhu,2 Xiang Hu,1 Qiuli Yu,3 Qianjin Zheng,1 Shengxiang Tao,1 Lihong Fan2 1Department of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China; 2School of Chemistry...

Glucosamine-paracetamol spray-dried solid dispersions with maximized intrinsic dissolution rate, bioavailability and decreased levels of in vivo toxic metabolites

Glucosamine-paracetamol spray-dried solid dispersions with maximized intrinsic dissolution rate, bioavailability and decreased levels of in vivo toxic metabolites Ahmed Mahmoud Abdelhaleem Ali,1,2 Ahmed Khames,1,2 Majed Mansour Alrobaian,1 Mohammad Hamaidi,3 Mohammed AS Abourehab4,5 1Department of Pharmaceutics, Faculty of Pharmacy, Taif University, Taif, Kingdom of Saudi Arabia...

Inhibitor of IGF1 receptor alleviates the inflammation process in the diabetic kidney mouse model without activating SOCS2

Inhibitor of IGF1 receptor alleviates the inflammation process in the diabetic kidney mouse model without activating SOCS2 Jiayu Li,1 Rong Dong,2 Jiali Yu,2 Sun Yi,2 Jingjing Da,2 Fuxun Yu,3 Yan Zha2 1Guizhou University School of Medicine, Guizhou University, 2Department of Nephrology, Guizhou Provincial People’s Hospital, 3Department of Central Laboratory, Guizhou Provincial...

Efficacy and safety of nicorandil on perioperative myocardial injury in patients undergoing elective percutaneous coronary intervention: results of the PENMIPCI trial

Efficacy and safety of nicorandil on perioperative myocardial injury in patients undergoing elective percutaneous coronary intervention: results of the PENMIPCI trial Ziliang Ye,1 Haili Lu,2 Qiang Su,1 Manyun Long,1 Lang Li1 On behalf of the PENMIPCI investigators 1Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People’s...

Monitoring antiangiogenesis of bevacizumab in zebrafish

Monitoring antiangiogenesis of bevacizumab in zebrafish Jing Zhang,1,2,* Beili Gao,1,* Wenchao Zhang,1 Zijun Qian,1 Yi Xiang1 1Department of Respiratory and Critical Care Medicine, Ruijin Hospital, Institute of Respiratory Diseases, School of Medicine, Shanghai Jiaotong University, Shanghai, People’s Republic of China; 2Respiratory Department of Shanghai East Hospital Affiliated...

Doxorubicin-conjugated dexamethasone induced MCF-7 apoptosis without entering the nucleus and able to overcome MDR-1-induced resistance

Doxorubicin-conjugated dexamethasone induced MCF-7 apoptosis without entering the nucleus and able to overcome MDR-1-induced resistance Kamontip Chaikomon,1,2 Supreecha Chattong,1,3 Theerasak Chaiya,1 Danai Tiwawech,4 Yongsak Sritana-Anant,5 Amornpun Sereemaspun,6 Krissanapong Manotham1 1Molecular and Cellular Biology Unit, Department of Medicine, Lerdsin General Hospital...

Therapeutic effect of protease-activated receptor 2 agonist SLIGRL-NH2 on loperamide-induced Sprague-Dawley rat constipation model and the related mechanism

Therapeutic effect of protease-activated receptor 2 agonist SLIGRL-NH2 on loperamide-induced Sprague-Dawley rat constipation model and the related mechanism Yonggang Zhang,1 Tingrui Ge,1 Ping Xiang,1 Haibing Mao,1 Shumin Tang,1 Aimin Li,2 Lin Lin,3 Yinting Wei4 1Department of Colorectal Surgery, The First People’s Hospital of Lianyungang, Lianyungang 222002, China; 2Department of...

Care pathways and treatment patterns for patients with heart failure in China: results from a cross-sectional survey

Care pathways and treatment patterns for patients with heart failure in China: results from a cross-sectional survey James DS Jackson,1 Sarah E Cotton,1 Sara Bruce Wirta,2 Catia C Proenca,3 Milun Zhang,4 Raquel Lahoz,5 Bogdan Balas,5 Frederico J Calado5 1Real World Research, Adelphi Real World, Bollington, UK; 2Real World Evidence, Cardio-Metabolic Franchise, Novartis Sweden AB...

Pharmacodynamic considerations of collateral sensitivity in design of antibiotic treatment regimen

Pharmacodynamic considerations of collateral sensitivity in design of antibiotic treatment regimen Klas I Udekwu,1,* Howard Weiss2,* 1Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden; 2Department of Mathematics, Georgia Institute of Technology, Atlanta, GA, USA *These authors contributed equally to this work Introduction...