The first true abiotic tertiary folded structures, i.e. at the exclusion of any aliphatic amino acid, have recently been introduced under the form of aromatic oligoamide helix–turn–helix foldamers stabilized by hydrogen bonds in organic ...
Cell membrane protein glycosylation is dependent on the metabolic state of the cell as well as exogenous nutrients available. Although the metabolism and interconversion of monosaccharides have been well-studied, their incorporation into cell surface ...
Regioselectivity is a crucial issue in Baeyer–Villiger (BV) oxidation. To date, few reports have addressed asymmetric BV oxidation of 3-substituted cycloketones due to the high difficulty of controlling regio- and stereoselectivity. Herein, we ...
Hydroxamic acids (HA) form stable complexes with a large variety of metal-ions, affording hydroxamates with high complexation constants. Hydroxamic acid moieties play a crucial role in the natural iron metabolism. In this work, 1,4,2-dioxazoles linked ...
The scarcity of efficient imaging technologies for precise cancer treatment greatly drives the development of new nanotheranostic based platforms that enable both diagnostic and therapeutic functions, together in a single formulation. Owing to the complicated ...
Dynamic covalent chemistry (DCC) is a widely used method for the self-assembly of three-dimensional molecular architectures. The orthogonality of dynamic reactions is emerging as a versatile strategy for controlling product distributions in DCC, yet the ...
The substrate-bound formylglycine generating enzyme forms a trigonal planar tris-thiolate Cu() complex ready for oxygen activation.The formylglycine generating enzyme (FGE) catalyzes oxidative conversion of specific peptidyl-cysteine residues to formylglycine. ...
Oxygen atoms of cationic dioxa and azaoxa [6]helicenes can be exchanged by amino groups to form azaoxa and diaza [6]helicenes respectively. The mild reaction conditions developed herein allow the construction of libraries of derivatives with sensitive ...
A novel strategy has been established to assemble a series of single (Z)- or (E)-1H-isoindole derivatives through selectively and sequentially activating carbon–nitrogen triple bonds in a multicomponent system containing various nucleophilic and ...
Hypercoordinate iodine has evolved as an impressive class of catalysts for various organic transformations. Extension of this idea to asymmetric applications, such as in the asymmetric difunctionalization of styrene or its derivatives, constitutes an ...
Efficient triplet photosensitizers are important for fundamental photochemical studies and applications such as triplet–triplet annihilation upconversion (TTA UC), photoredox catalytic organic reactions and photovoltaics. We now report a series ...
Understanding the structural ordering and orientation of interfacial molecular assemblies requires an insight into the penetration depth of the probe molecules which determines the interfacial reactivity. In contrast to the conventional liquid probe-based ...
Intracellular microRNA (miRNA) detection has attracted increasing attention, resulting in significant achievements. However, the development of an available tool that possesses a satisfactory signal-to-background ratio and high sensitivity for miRNA detection ...
In the last decade, perovskite solar cells have been considered a promising and burgeoning technology for solar energy conversion with a power conversion efficiency currently exceeding 24%. However, although perovskite solar cells have achieved high power ...
Although living supramolecular polymerization (LSP) has recently been realized, the scope of the monomer structures applicable to the existing methods is still limited. For instance, a monomer that spontaneously nucleates itself cannot be processed in ...
Central-to-axial chirality conversion provides efficient access to axially chiral compounds, and several examples regarding the conversion of one, two or four stereocenters to one axis have been reported. Herein, we report the conversion of two stereocenters ...
A remarkably strained cyclopyrenylene trimer CP3 was synthesized and it underwent the first biaryl C–C σ-bond cleavage by direct oxygen insertion without the aid of any metal agents. A priori highly strained CP3 exhibits the longest wavelength ...
Multifunctional mononuclear iron() complex coordinated with six phosphorescent ligands exhibiting correlated spin-crossover transition and enhanced fluorescence.We present a new example of a mononuclear iron() complex exhibiting a correlated spin-crossover ...
We present a comprehensive investigation of the magnetic and optical properties of an ytterbium complex, which combines two desirable and practical features into a single molecular system. Based upon Yb[III] ions that promote near-infrared optical activity ...
Since the conception of the electron pair bond, Lewis structures have been used to illustrate the electronic structure of a molecule in its ground state. But, for excited states, most descriptions rely on the concept of molecular orbitals. In this work ...
Polymer dots (Pdots) have become a type of attractive illuminant for electrochemiluminescence (ECL). However, the low ECL efficiency severely limits their practicability. Here, we design a dual intramolecular resonance energy transfer (RET) mechanism ...
Achieving a higher dissymmetry factor is a crucial issue in developing circularly polarized luminescence (CPL) materials. Here, by tailoring the solvent composition and the morphology of the same chiral emissive small molecules (R- or S-SPAn), circularly ...
Current methods for metal chelation are generally based on multidentate organic ligands, which are generated through cumbersome multistep synthetic processes that lack flexibility for systematically varying metal-binding motifs. Octadentate ligands incorporating ...
The successful application of Hammett parameters as input features for regressive machine learning models is demonstrated and applied to predict energies of frontier orbitals of highly reducing tungsten–alkylidyne complexes of the form W(CArR)L[4] ...
Amyloidogenic peptides are considered central pathological contributors towards neurodegeneration as observed in neurodegenerative disorders [e.g., amyloid-β (Aβ) peptides in Alzheimer's disease (AD)]; however, their roles in the pathologies ...