Chromatographic separation of n-hexane and ethyl acetate fraction of a crude methanol extract obtained from aerial parts of the Scorzonera aucheriana DC collected from Sivas province of Turkey yielded nine natural compounds; two new 3-caffeoyl-quinic acid analogs (1-2), one new taraxasterol oleate (3), and six known triterpenoids taraxasterol (4), taraxasterol acetate (5...
3-acetyl coumarin derivatives (1a-d) are formed as a result of condensation of salicylaldehyde derivatives and ethyl acetoacetate and were converted into coumarin-selenophene hybrid compounds (2a-d) in the basic medium by modified Gewald reaction in the presence of malononitrile and selenium. Products are characterized by nuclear magnetic resonance (NMR). The prepared compounds...
In this study, we report a simple and economic one-pot synthesis of magnetite (Fe3O4) nanostructure and its modification with tetraethyl orthosilicate by coprecipitation method. The synthesized (Fe3O4@SiO2) nano sorbent was applied for enhanced adsorptive removal of methylene blue by ultrasonic wave driven batch experiments. After successful synthesis, the nanostructure was...
This study reports a detailed analysis of an electrode material containing poly(phenolphthalein), carbon nanotubes and gold nanoparticles which shows superior catalytic effect towards to hydrazine oxidation in Britton-Robinson buffer (pH 10.0). Glassy carbon electrode was modified by electropolymerization of phenolphthalein (PP) monomer (poly(PP)/GCE) and the multiwalled carbon...
The presence of heavy metals in environmental waters having an important place in the industrial waste is a major threat to viability. Heavy metals are transported to humans through the ecological cycle, damaging many tissues and organs. In recent years, agricultural and food waste can be used to remove heavy metals. At the present study, magnetically modified coffee grains which...
The current study describes the synthesis, electrochemical, computational, and photochemical properties of octa (3-hydroxypropylthio) substituted cobalt (II) (4), copper (II) (5), nickel (II) (6) and zinc(II) (7) phthalocyanine derivatives. These novel compounds were characterized by elemental analysis, H-1, C-13 NMR, FT-IR, UV-Vis, and MS. The redox behaviors of these...
In this study, quantative nuclear magnetic resonance (qNMR) method was used to determine the content of rosuvastatin in tablet. Linearity, range, limit of detection (LOD), limit of quantification (LOQ), accuracy, and precision were determined in validation study of rosuvastatin. Furthermore, validation study of rosuvastatin was performed with high performance liquid...
Formaldehyde (FA, CH2O) is one of the toxic volatile organic compounds that cause harmful effects on the human body. In this work, the interaction of FA gas with metal phthalocyanine (MPc) molecules was studied by employing density functional theory calculations. A variety of [MPc](a) (M = Sc, Ti, and V; a = -1, 0, and +1) complexes were studied, and the electronic properties...
Alpha-1 antitrypsin (A1AT) is one of the acute phase proteins which are synthesized in the liver. A1AT inhibits the activity of many proteases, but its main task is to protect the lungs from the attack of neutrophil elastase. In an autosomal hereditary disease known as alpha-1 antitrypsin deficiency, the A1AT level in blood serum decreases, increasing the risk of developing...
This study was conducted to investigate the physicochemical, phytochemical, in vitro antidiabetic and anticancer potential of Olea ferruginea R bark. After extraction using Soxhlet, in vitro antidiabetic and cytotoxic activity on human hepatocellular carcinoma (HepG2) cells was assessed by nonenzymatic glycosylation of hemoglobin assay, alpha-amylase inhibition assay, glucose...
Spectrophotometric monitoring of 4-nitrophenol (4-NP) reduction by sodium borohydride (NaBH4) using gold nanoparticles (GNPs) as a catalyst has been extensively studied, but the stability of GNPs in terms of change in the surface plasmon resonance (SPR) at different temperatures has not been explored. In the present investigation, our aim was to evaluate the SPR stability of GNPs...
Liquid crystal (LC) compound 4-Benzyloxyphenyl 4-[4-(n-dodecyloxy)benzoyloxy]benzoate (BDBB) was prepared and characterized. Inverse gas chromatography (IGC) was to be a beneficial analysis method for the research of thermodynamic characteristics of the new LC. Acetate and alcohol isomers were used to examine LC selectivity via the IGC technique at temperatures between 333.2 K...
This paper includes the results of the first study about the phenolic characteristics and antimicrobial analyses of Geranium ibericum subsp. jubatum species found in Turkey. In the present work, the phenolic contents of different parts of the G. ibericum (flower, root, leaf) were determined with high-performance liquid chromatography (HPLC)-DAD (diode-array detector) and liquid...
A series of polymer/clay nanocomposites containing mechanistically two different polymers, poly(ethylene glycol) (PEG) and poly(epsilon caprolactone) (PCL), were prepared by simultaneous copper(I)-catalyzed alkyne-azide cycloaddition click reactions. Both clickable polymers, PEG-Alkyne and PCL-Alkyne, were simultaneously clicked on to azide-functional montmorillonite (MMT-N-3...
Dipyrromethanes are useful mediator structures which can be used as a part of other molecules such as bis-porphyrins and their derivations. Various methods have been developed for their synthesis. This study presents the synthesis of a new bis-dipyrromethane, 7,12-bis(4-(di(1H-pyrrol-2-yl)methyl)phenyl)benzo[k]fluoranthene, using the Lewis acid catalyzed reaction between a new...
The new type of coronavirus, SARS-CoV-2 has affected more than 22.6 million people worldwide. Since the first day the virus was spotted in Wuhan, China, numerous drug design studies have been conducted all over the globe. Most of these studies target the receptor-binding domain of spike protein of SARS-CoV-2, which is known to bind to the human ACE2 receptor and SARS-CoV-2 main...
The prostate-specific membrane antigen (PSMA) represents an ideal biomarker for molecular imaging. Various PSMA-targeted radioligands are available for prostate cancer imaging. In this study, labeling of PSMA I&T with Ga-68, as well as validation of the radiochemical purity of the synthesis product by reverse phase radio high-performance liquid chromatography (HPLC) method are...
3-[5-(diethylamino)-2-formylphenoxy]phthalonitrile (n-TY-CN), metallophthalocyanines n-TY-Co, n-TY-Cu, and n-TY-Mn bearing [5-(diethylamino)-2-formylphenoxy] groups at nonperipheral positions were prepared for the first time. These compounds were characterized with IR, NMR (only for n-TY-CN), mass and UV-vis (except n-TY-CN) spectroscopy. Voltammetric characterizations of n-TY-Co...
Dye-contaminated wastewaters are industrial wastewaters that are difficult to treat using traditional biochemical and physicochemical methods. In the present work, the acid red G was removed as a model pollutant by the electro-Fenton process for the first time. The anode and cathode used by the electro-Fenton process were iron plate and graphite felt, respectively. It was...
Prof. Dr. O. Yavuz Ataman passed away on August 15, 2020, in Ankara. He was an academic as well as a social figure throughout his life. He had remarkable achievements in academy as a researcher, an educator, and an administrator. He was known for his unique approaches to the events in all aspects of life. With his beloved character, he was really special. With Prof. Ataman’s...
Marine compound dendrodoine was first obtained from tunicate species (Dendrodo grossularia). It has a five-membered ring, namely, it is a heterocycle thiadiazole, which is found rarely in natural sources. Following its biological activities, novel analogs have been investigated recently. Synthesis of the analogs for this study is realized with uncommon thiazole closure, including...
In this study, boric acid (BA) is employed as a crosslinking agent to improve the characteristics of two commonly used polymeric films, ethyl cellulose (EC) and polyvinyl alcohol (PVA), for topical drug delivery applications. The developed films are characterized by FIT R spectroscopy and SEM analysis. The results show that the surfaces of the prepared films are even and...
A fluorescent probe based on silicon quantum dots (SiQDs) was developed for the selective and sensitive detection of oxytetracycline (OTC) via the inner filter effect (WE). The water-soluble fluorescent SiQD was synthesized based on the reaction of 3-Aminopropyltriethoxysilane (APTES) and sodium citrate as precursors by the one-pot hydrothermal process. The strong fluorescence...
EndoBI-1 and EndoBI-2 are two endo-β-N-acetylglucosaminidase isoenzymes that cleave N-N’-diacetylchitobiosyl moieties found in various types of native N-glycans. These N-glycans are indigestible by human infants and adults due to the lack of responsible glycosyl hydrolases and they act as selective prebiotics for a probiotic microorganism, Bifidobacterium longum subsp. infantis...
In the present study, high-performance liquid chromatography (HPLC) was used for the separation of tocopherols and triglycerides of processed soybean oil and deodorizer distillate (DD). The results of normal and reversed-phase modes of HPLC revealed that concentrations of tocopherols and triglycerides content were decreased during the neutralization, bleaching, and deodorization...