Aging Clinical and Experimental Research

http://link.springer.com/journal/40520

List of Papers (Total 135)

Levothyroxine treatment and incident dementia in adults with atrial fibrillation

ObjectiveLevothyroxine treatment is common among older adults as is atrial fibrillation (AF), yet less is known about its potential effects on the development of dementia.MethodsThe study population included all adults with diagnosed AF (n = 156,104) aged ≥ 45 years in Sweden without an earlier recorded diagnosis of dementia. Individuals with a dispensed prescription of...

Gait in patients with symptomatic osteoporotic vertebral compression fractures over 6 months of recovery

BackgroundOne factor related to disability in people with spinal deformity is decreased postural control and increased risk of falling. However, little is known about the effect of osteoporotic vertebral compression fractures (OVCFs) and their recovery on gait and stability. Walking characteristics of older adults with and without vertebral fractures have not yet been compared...

Relationship between comorbidities and treatment decision-making in elderly hip fracture patients

BackgroundElderly patients are at a higher risk for hip fracture. Moreover, hospitalized elderly patients with hip fracture are vulnerable to adverse outcomes including higher mortality rate and long-term disability. Treatment decision-making with respect to surgical procedure and perioperative management of these patients is typically challenging owing to the presence of...

Comprehensive geriatric assessment in primary care: a systematic review

BackgroundComprehensive geriatric assessment (CGA) involves the multidimensional assessment and management of an older person. It is well described in hospital and home-based settings. A novel approach could be to perform CGA within primary healthcare, the initial community located healthcare setting for patients, improving accessibility to a co-located multidisciplinary team...

Prevalence and associated factors of poor sleep quality among Chinese older adults living in a rural area: a population-based study

ObjectiveTo investigate the prevalence and associated factors of poor sleep quality among community-dwelling elderly population in a rural area of Northern China.MethodsWe conducted a cross-sectional survey in August–December 2014 and recruited 2195 participants who were aged 65 years or older and living in Yanlou Town of Yanggu County in western Shandong Province, China. Data on...

Impact of osteoarthritis on activities of daily living: does joint site matter?

BackgroundWe consider the relationships between a clinical and radiological diagnosis of knee or hip OA and activities of daily-living (ADL) in older adults.MethodsData were available for 222 men and 221 women from the Hertfordshire Cohort Study (HCS) who also participated in the UK component of the European Project on Osteoarthritis (EPOSA). Participants completed the EuroQoL...

Untangling the relationship between fat distribution, nutritional status and Parkinson’s disease severity

BackgroundParkinson’s disease (PD) is responsible for significant changes in body composition.AimsWe aimed to test the association between PD severity and fat distribution patterns, and to investigate the potential modifier effect of nutritional status in this association.MethodsWe enrolled 195 PD subjects consecutively admitted to a university geriatric day hospital. All...

Factors associated with hospitalization for community-acquired pneumonia in home health care patients in Taiwan

BackgroundPneumonia is a leading cause of hospitalization and death worldwide. However, studies focusing on risk factors of community-acquired pneumonia (CAP) in the home health care (HHC) population remain scarce.AimsThis study aimed to evaluate risk factors associated with hospitalization for CAP among HHC patients in Taiwan.MethodsThis retrospective cross-sectional study...

Latin American Adult Immunisation Advocacy Summit: Overcoming regional barriers to adult vaccination

Older adults in Latin America are at an increased risk of hospitalisation, ill health, catastrophic disability and death due to vaccine-preventable diseases such as influenza, herpes zoster, and pneumonia. The Latin American Adult Immunisation Advocacy Summit, held in Mexico City, gathered 40 experts in health, ageing and immunisation from 12 Latin American countries to explore...

Long-term strength and balance training in prevention of decline in muscle strength and mobility in older adults

BackgroundReductions in muscle strength and poor balance may lead to mobility limitations in older age.AimsWe assessed the effects of long-term once-weekly strength and balance training (SBT) on muscle strength and physical functioning in a community-based sample of older adults.Methods182 individuals [130 women and 52 men, mean age 80 (SD ± 3.9) years] underwent supervised SBT...

The role of omega-3 in the prevention and treatment of sarcopenia

Sarcopenia is a geriatric syndrome with increasing importance due to the aging of the population. It is known to impose a major burden in terms of morbidity, mortality and socio-economic costs. Therefore, adequate preventive and treatment strategies are required. Progressive resistance training and protein supplementation are currently recommended for the prevention and treatment...

The effect of ageing on shear wave elastography muscle stiffness in adults

BackgroundSkeletal muscle undergoes structural changes with ageing which may alter its biomechanical properties. Shear wave elastography (SWE) may detect these changes by measuring muscle stiffness.AimsTo investigate muscle stiffness in healthy young, middle-aged and elderly cohorts using SWE and correlate it with muscle strength and mass.MethodsShear wave velocity (SWV) was...

Cost-effectiveness evaluation of glucosamine for osteoarthritis based on simulation of individual patient data obtained from aggregated data in published studies

BackgroundThe economic evaluation of treatments usually requires access to individual patient data, which is difficult to obtain. Moreover, in osteoarthritis, health utility scores are unavailable and can be assessed only using a validated equation model based on various clinical data. We aimed to develop and validate a methodology to simulate individual health utility scores...

The effects of same-session combined exercise training on cardiorespiratory and functional fitness in older adults: a systematic review and meta-analysis

Endurance and strength training are effective strategies for counteracting age-associated reductions in physical performance in older adults, with a combination of both exercise modes recommended to maximise potential fitness benefits. This meta-analysis sought to quantify the effects of same-session combined endurance and strength training on fitness in adults aged over 50 years...

Consistency and test–retest reliability of stepping tests designed to measure self-perceived and actual physical stepping ability in older adults

BackgroundOlder adults with an incorrect perception of their physical abilities may fall more often, suggesting a need for tests to quantify self-perceived and actual abilities.AimsTo determine between-test consistency and test–retest reliability of three tests that measure self-perceived and actual stepping ability in older adults.MethodsOlder adults performed three stepping...

Executive summary of European guidance for the diagnosis and management of osteoporosis in postmenopausal women

A guidance on the assessment and treatment of postmenopausal women at risk from fractures due to osteoporosis was recently published in Osteoporosis International as a joint effort of the International Osteoporosis Foundation and European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (Kanis et al. Osteoporos Int,  https://doi.org/10.1007/s00198-018...

Midlife predictors of active and healthy aging (AHA) among older businessmen

BackgroundActive and healthy aging (AHA) is an important phenomenon in aging societies.AimsOur aim was to investigate midlife predictors of AHA in a socioeconomically homogenous male cohort.MethodsIn 2010, AHA was defined in the Helsinki Businessmen Study (men born in 1919–1934) with six criteria: (1) being alive, (2) responding to the mailed survey, (3) no reported cognitive...

Assessment of health literacy among older Finns

AimsThis study examined the feasibility of the HLS-EU-Q16 (in Finnish) for use among older Finns and whether the health literacy score correlates with indicators of health and functioning.MethodsTo determine the feasibility of the instrument, we first conducted a focus group discussion with nine participants. For the quantitative analyses, we used data from the AGNES cohort study...

Influence of bone densitometry on the anti-osteoporosis treatment after fragility hip fracture

BackgroundFragility fracture significantly increases risk of future fracture. The fragility fracture cycle should be disrupted. The secondary fracture prevention is important for the patients with fragility hip fracture. The pharmacotherapy for osteoporosis is important for prevention of new fracture. However, many patients with hip fracture do not receive osteoporosis treatment...

A new decision tree for diagnosis of osteoarthritis in primary care: international consensus of experts

Background and aimsAlthough osteoarthritis (OA) is managed mainly in primary care, general practitioners (GPs) are not always trained in its diagnosis, which leads to diagnostic delays, unnecessary resource utilization, and suboptimal patient outcomes.MethodsTo address this situation, an International Rheumatologic Board (IRB) of 8 experts from 3 continents developed guidelines...

The Finnish Interprofessional Medication Assessment (FIMA): baseline findings from home care setting

PurposeMedication-related problems and declined functional capacity are closely associated factors among older people. The purpose of this study is to describe the procedure of interprofessional medication assessment in home care context and the baseline characteristics of the study population.MethodsThe FIMA study was a randomized, controlled intervention study comparing general...

Simulating the effects of a clinical guidelines screening algorithm for fall risk in community dwelling older adults

BackgroundThe current guidelines for fall prevention in community-dwelling older adults issued by the American Geriatrics Society and British Geriatrics Society (AGS/BGS) indicate an algorithm for identifying who is at increased risk of falling. The predictive accuracy of this algorithm has never been assessed, nor have the consequences that its introduction in clinical practice...