Natural coumarin-hemiterpene ethers (NCHEs) are secondary metabolites characterized by the attachment of an isoprenyl group to the coumarin scaffold via an ether bond. There is no review of the biological activities of these compounds. This paper reviews the various bioactivities of coumarin-hemiterpene ethers of plant origin, whether synthesized or isolated from plant species...
Background and objectives: Dracocephalum subcapitatum is a plant indigenous to northeastern Iran with some traditional applications and limited pharmacological data. Since antidiabetic activities have been reported for several species of Dracocephalum genus, this study aimed to explore the effects of the hydroalcoholic extract of D. subcapitatum in an animal model of diabetes...
Background and objectives: Sanguisorba minor Scop. is a perennial species widely distributed throughout Iran. Its leaves are commonly used in salads, beverages, and various dishes. Sanguisorba minor has been used in traditional medicine to treat bleeding, diarrhea, duodenal ulcers, and intestinal infections. The present study aimed to isolate the non-volatile constituents of S...
Background and objectives: Non-alcoholic fatty liver disease (NAFLD) has increased in prevalence, morbidity, and mortality. Sedentary lifestyles and poor dietary habits contribute to those rates, highlighting the importance of effective prevention and treatment. Sida rhombifolia exhibits anti-inflammatory properties, but its potential in NAFLD remains insufficiently explored. In...
Gums are well-known representatives of the polysaccharides class and are used extensively in the pharmaceutical, food, and cosmetic industries as gelling, dissolving, emulsifying, stabilizing, and thickening agents. Plant-based gums are used in traditional Persian medicine (TPM) for rectal drug delivery as versatile natural compounds. Following the importance of using...
Background and objectives: Sponge Aaptos aaptosSchmidt is reported to have bioactive chemicals that can serve as medication substances. This research aimed to determine the antimycobacterial activity of alkaloid aaptamines from the sponge A. aaptos and study the molecular docking of the active compounds. Methods: The structural characterization of the isolated compounds was...
Background and objectives: Ulcerative colitis is a chronic inflammatory bowel disease characterized by mucosal and submucosal damage in the colon. This study evaluated the protective effect of Oliveria decumbens Vent. (locally known as “Moshkoorak”), a plant used in the folk medicine of southwest Iran for treating infectious and digestive disorders, as well as acetic acid-induced...
Background and objective: Fatigue is a complex condition impacting both physical and mental performance, classified into acute and chronic types. Chronic fatigue can arise from prolonged sleep deprivation, negatively affecting cognitive function and quality of life. This study aimed to evaluate the anti-fatigue effects of Elletaria cardamomum (cardamom), in a rat model of chronic...
Background and objectives: Acute pancreatitis is a severe inflammatory disease with increasing incidence in the population. Rosa damascena Mill. is widely distributed worldwide, and its antioxidant and immunomodulatory effects have been confirmed. This study was conducted to investigate the effect of the methanol extract of R. damascena in an animal model of cerulein-induced...
Tribulus terrestris L. is a well-recognized medicinal plant with a long-standing history in traditional healing systems, including Ayurveda, Unani, and Chinese medicine. It is widely known for its therapeutic efficacy in enhancing reproductive health, regulating lipid metabolism, and supporting liver and kidney functions. This review compiles and analyzes the existing scientific...
The use of herbal remedies is globally increasing due to the supposed advantages of being natural means of health. Serious concerns regarding the safety and efficacy of these remedies, especially gastrointestinal (GI) side effects, have arisen. A literature search was done using Google Scholar, Web of Science, and PubMed databases with recent time frame (2002 to 2025). This...
Background and objectives: Diabetes mellitus (DM)-induced hypertrophic cardiomyopathy (HCM) is the main reason for the high morbidity rate. 6-Gingerol has been shown to alleviate HCM by reducing oxidative stress and inflammation. The present study investigated its underlying mechanism, focusing on the activation of the AMPK/PGC-1a/SIRT1 pathway, aiming to reveal its therapeutic...
This review focuses on the phytochemical composition and biological activity of frequently consumed berries, including bilberries, raspberries, blueberries, cranberries, and strawberries, with a focus on their anti-proliferative properties in preventing oral cancer. To analyse the cytotoxic effects of berry phytoextracts on oral squamous cell cancer (OSCC) from January 2014 to...
Background and objectives: Cucurbita pepo L. subsp. pepo (green zucchini morphotype) is rich in phytochemicals, making it a promising candidate for vaginal dryness according to Persian medicine. This study aimed to formulate a vaginal cream containing green zucchini extract and to assess the vaginal irritation potential of the product in vivo. Method: A vaginal cream was...
Background and objectives: Ginkgo biloba extract with beneficial effects to treat some diseases such as cancer, cardiovascular and nervous system disorders has wide spread application in medicine. Due to several side effects of G. biloba extract consumption, gene expression profiles of the long term treated mouse liver was analyzed via protein-protein interaction (PPI) network...
Background and objectives: Doxorubicin is an antineoplastic agent whose administration may cause cardiotoxicity. Opuntia ficus-indica is a widely consumed cactus species with nutritional and antioxidant value. In this study, the effect of fruit extracts of Opuntia ficus-indica on doxorubicin-induced cardiotoxicity was investigated in vitro. Methods: Hydroalcoholic and anthocyanin...
Background and objectives: This study seeks to document the traditional knowledge of medicinal plants from Fars Province, Iran, used in the treatment of common oral diseases. Methods: A structured questionnaire, developed at the School of Pharmacy, was administered in health centers across Fars province to conduct a large-scale survey on the effects of medicinal plants on various...
Background and objectives: Angiogenesis, the biological process of new blood vessel formation from existing vasculature, plays a critical role in wound healing and tumor progression. This study aimed to evaluate the angiogenic activity of the aqueous extract of Peucedanum knappii Bornm. using the chick chorioallantoic membrane (CAM) assay. Methods: The crude extract (80% methanol...
Background and objectives: Flaxseed (Linum usitatissimum L.) as an outstanding food with beneficial properties contains omega-3 fatty acids, lignans, α-linolenic acid, and digestible proteins. Investigation of sleep improvement of flaxseed via network analysis was the main aim of this study. Methods: The dysregulated genes in response to flaxseed consumption were derived from...
In this study, we performed a systematic review to evaluate the efficacy of Rowatinex® and Renotinex®, two almost similar terpene combination in managing urolithiasis. After searching various databases, thirty-one studies of different types and settings were chosen for full review. We selected six efficacy indicators to assess the success of these products in treatment. The data...
Background and objectives: Pregnant mothers with obesity may increase the risk of adverse health outcomes for their infants, such as weakened immune systems. Currently, there is no standardized treatment for obese pregnant women to reduce risks to the mothers and their infants. Zingiber officinale (ginger) is a commonly used medicinal plant to relieve symptoms associated with...
Background and objectives: Sexual issues, especially erectile dysfunction, are common among men undergoing methadone maintenance treatment (MMT). This study aimed to explore the effects of a Persian Medicine product, “Dava al-basal”, on erectile dysfunction and testosterone levels in men receiving MMT. Methods: This double-blind randomized clinical trial involved 60 men who were...
Background and objectives: Autism spectrum disorder (ASD) is a complicated disorder. Hazelnut and Zante can be of great importance in controlling autism due to their high antioxidant and anti-inflammatory capacities. Methods: Zante currant was mixed with distilled water and condensed. Hazelnut and honey were added afterwards. The mixture was diluted with distilled water to obtain...
Background and Objectives: Mimosa pudica L., belonging to the Fabaceae family, has been used in the Cuban traditional culture by exposure to smoke of aerial parts combustion and in the smokable form of cigarettes, for recreational or leisure purposes and medical applications. The aim of this study was to evaluate the toxicity and physical dependence of M. pudica by the acute...
Background and objectives: Cisplatin is one of the most widely used anti-cancer drugs. Some less well-known side effects, like genotoxicity, are linked to the widespread use of cisplatin. Kaempferol and quercetin are two antioxidant flavonoids. This study aimed to investigate the genotoxicity of cisplatin in human peripheral lymphocytes, as well as the protective effects of...