The role of the pharmacist in the management of type 2 diabetes: current insights and future directions

Integrated Pharmacy Research and Practice, Jan 2017

The role of the pharmacist in the management of type 2 diabetes: current insights and future directions Jeffery David Hughes,1 Yosi Wibowo,2 Bruce Sunderland,1 Kreshnik Hoti1,3 1School of Pharmacy, Curtin University, Perth, WA, Australia; 2Centre for Medicines Information and Pharmaceutical Care (CMIPIC), Faculty of Pharmacy, Universitas Surabaya, Surabaya, Indonesia; 3Department of Pharmacy, Faculty of Medicine, University of Prishtina, Prishtina, Kosovo Abstract: Type 2 diabetes is a chronic disease occurring in ever increasing numbers worldwide. It contributes significantly to the cost of health globally; however, its management remains in the most part less than optimal. Patients must be empowered to self-manage their disease, and they do this in partnership with health care professionals. Whilst the traditional role of the pharmacist has been centered around the supply of medicines and patient counseling, there is an evergrowing body of evidence that pharmacists, through a range of extended services, may contribute positively to the clinical and humanistic outcomes of those with diabetes. Further, these services can be delivered cost-effectively. This paper provides a review of the current evidence supporting the role of pharmacists in diabetes care, whilst providing a commentary of the future roles of pharmacists in this area. Keywords: pharmacy, interventions, outcomes, benefits, glycemic control, cost-effectiveness

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The role of the pharmacist in the management of type 2 diabetes: current insights and future directions

Integrated Pharmacy Research and Practice The role of the pharmacist in the management of type 2 diabetes: current insights and future directions Jeffer y David Hughes 2 Bruce Sunderland 2 Kreshnik Hoti 0 2 0 Department of Pharmacy, Faculty of Medicine, University of Prishtina , Prishtina, Kosovo 1 Centre for Medicines Information and Pharmaceutical Care (CMIPIC), Faculty of Pharmacy , Universitas Surabaya, Surabaya , Indonesia 2 School of Pharmacy, Curtin University , Perth, w A , Australia Type 2 diabetes is a chronic disease occurring in ever increasing numbers worldwide. It contributes significantly to the cost of health globally; however, its management remains in the most part less than optimal. Patients must be empowered to self-manage their disease, and they do this in partnership with health care professionals. Whilst the traditional role of the pharmacist has been centered around the supply of medicines and patient counseling, there is an evergrowing body of evidence that pharmacists, through a range of extended services, may contribute positively to the clinical and humanistic outcomes of those with diabetes. Further, these services can be delivered cost-effectively. This paper provides a review of the current evidence supporting the role of pharmacists in diabetes care, whilst providing a commentary of the future roles of pharmacists in this area. Diabetes mellitus (“diabetes”) is one of the fastest growing chronic diseases worldwide, and is associated with significant morbidity, mortality, and health care costs. Diabetes is characterized by high levels of glucose in the blood (hyperglycemia). There are three main types of diabetes: pharmacy; interventions; outcomes; benefits; glycemic control; cost-effectiveness - ldedao rpeoF open access to scientific and medical research Introduction • Type 1 diabetes mellitus (T1DM) in which there is an absolute deficiency in insulin production. This disease can occur at any age, although it mostly occurs in children and young adults.1 Type 2 diabetes mellitus (T2DM) which is associated with insulin resistance, with an initial increase in insulin secretion, however over time, beta cell death and insulin insufficiency. Although T2DM mainly occurs in people aged over 40 years old, the disease is also becoming increasingly prevalent in the younger age group.2,3 Gestational diabetes which occurs during pregnancy. The condition usually disappears once the baby is born; however, a history of gestational diabetes increases a woman’s risk of developing T2DM later in life.1 The statistics related to diabetes mellitus globally are alarming. The International Diabetes Federation (IDF) Diabetes Atlas, Seventh Edition, 2015, provides the following estimates: one in 11 adults have diabetes (416 million), nearly half (46.5%) of adults with diabetes are undiagnosed, one in seven births are affected by gestational diabetes, 542,000 children have type 1 diabetes, and a person dies from diabetes every 6 seconds.4 Further, the IDF estimates that by 2040, one in 10 adults (642 million) will have diabetes.4 Of those people with diabetes, three quarters (75%) live in low- and middle-income countries.4 The Western Pacific region (which includes Australia) has 37% of all adults living with diabetes. This includes 100 million people in the People’s Republic of China (ranked highest in number of people with 8 diabetes), 10 million people in Indonesia (seventh highest), l-201 and 7.2 million in Japan (ninth highest). Also included in this -J2u region is the country with the highest prevalence of diabetes 1n the Pacific Island nation of Tokelau where 30% of the adult 53o population has diabetes. Globally, Cambodia has the lowest .541 prevalence of diabetes at 3%.4 .532 T2DM is the greatest contributor to the burden of dia.51 betes globally accounting for up to 90% of people with /yb diabetes worldwide.4 Further, its prevalence is increasing in .com all countries around the world. This increase has paralleled rsse the global epidemic of obesity. It is estimated that since vpoe 1980 worldwide, obesity has nearly doubled. In 2008, it was .d estimated that there were 1.4 billion adults (35% of those //www l.yno 20 years or older) who were overweight, of which over half t:sp sue a billion (11%) were obese.5 Importantly, it is reported that thom lsaon being overweight or obese contributes significantly to the ldedao rpeoF cbeurrtdaeinn coafndciearbse(treasn(g4e47%%),–i4sc1h%e)m.5iYcehte,aorbtedsiistyeaissep(r2ev3e%n)ta,banled, fr r and strategies to prevent diabetes and cardiovascular disease both include the common goal to optimize peoples’ weight through diet and exercise. Adults with diabetes have a two- to threefold increased risk of suffering a heart attack or stroke compared to those without diabetes.6 The microvascular complications of diabetes mellitus make it the leading cause of preventable blindness, renal disease, and amputation in developed countries.6–8 These complications have dramatic implications for health care costs, with the total annual cost impact of diabetes in Australia estimated to be at $14.6 billion,9 whilst globally, it is estimated to account for 12% of the global health expenditure (US$673 billion).4 By 2040, it is estimated that the proportion of global health expenditure will exceed US$802 billion.4 Optimizing therapy in patients with diabetes is a difficult clinical task requiring considerable patient education and motivation. The goal is to improve glycemic control without adverse bodyweight gain or hypoglycemia, and with a positive or neutral effect on lipid levels and blood pressure. Proper drug selection involves identifying the drug that is most likely to improve control and least likely to cause interactions, and adverse effect or adherence problems. Consequently, it has the potential to change patients’ futures and health care systems’ costs.10 16 Pharmacists represent the third largest health profession in the world11 after doctors and nurses. Most pharmacists work in the community with a smaller proportion in hospital pharmacy, academia, industry, and research. Community pharmacies provide a range of products (in respect to diabetes prescription and nonprescription medication, blood glucose meters and testing strips, needles and swabs, dietary supplements) and services (such as medication review, vaccination, unit dose dispensing, needle exchange, point of care testing, disposal of unwanted medicines, etc).12 Community pharmacists are considered to be the most accessible health care professionals, as no appointments are required to see them, and to have the highest level of patient contact. As such, they are well placed to play a significant role in the care of patients with T2DM. This review discusses the health care requirements of T2DM and the current and future roles of pharmacists in its management. For the purposes of the review, papers were identified from English language PubMed and ScienceDirect databases up until October 2016, and by manually reviewing the references for the papers adjudged relevant based on title and abstract, and then full paper review. The keywords used included diabetes, pharmacist, pharmacy, intervention, glycosylated hemaglobin (HbA1c), improvement, benefit, and outcomes. Papers critiqued in this review include original research papers, together with systematic reviews and metaanalyses. The paper aims to provide an overview of the current evidence for the role of pharmacists in diabetes care and insights into what roles pharmacists may fulfill in the future. Health care for T2DM patients The management of those with T2DM should be seen as a partnership between the patient and health care professionals, in which the latter support the former in self-managing his or her disease. Management of every patient should commence with a detailed assessment at the initial diagnosis including an appraisal of diabetes complications and risk factors for complications. This provides the basis for continuing care that includes a treatment plan, treatment administration, monitoring, and review (Figure 1 and Table 1).1,13–16 Pharmaceutical care is defined as “the responsible provision of drug therapy for the purpose of achieving definite outcomes that improve a patient’s quality of life”.17 It provides a platform for multidisciplinary collaboration, which means that the pharmacist and the doctor (and potentially other care providers) join forces to decide on the optimal treatment of the patient so as to achieve the outcome the patient desires.18 It requires that a professional relationship 8 1 0 2 l u J 2 1 n o 3 5 1 . 4 5 2 . 5 3 1 . 5 y b / m o c . s s e r p e v o d . //www l.yno t:sp sue th la om son fr r T2DM patients Initial assessment • Medical history • Physical examination • Laboratory evaluation between the pharmacist and the patient is established and maintained, and records on patient’s medications and other specific information are collected and evaluated. In the case of prescription medicines, a therapy plan currently needs to be developed involving the doctor and the patient;18 however, pharmacists may also provide input here. one practitioner can reasonably provide to achieve optimal therapeutic outcomes for the patient.1,14 With the development of the concept of pharmaceutical care in which pharmacists are engaged more widely in patient care,18 the opportunity exists for pharmacists to have a greater role in the care of patients with T2DM. Pharmacy-based services for T2DM patients T2DM is one of a number of common complex conditions, including asthma, chronic obstructive pulmonary disease and heart failure, which require more time and expertise than Evidence of the benefits of pharmacists in the care of T2DM patients Extensive studies worldwide have evaluated the effectiveness of pharmacy-based interventions in supporting people submit your manuscript | www.dovepress.com Dovepress 17 ldedao rpeoF Note: Data from references 1 and 13–15. Abbreviations: BGL, blood glucose level; BMI, body mass index; eGFR, estimated glomerular filtration rate; HbA1c, glycosylated hemoglobin; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; SMBG, self-monitoring of blood glucose; T2DM, type 2 diabetes mellitus. 8 1 0 2 l u J 2 1 n o 3 5 1 . 4 5 2 . 5 3 1 . 5 y b / m o c . s s e r p e v o d . //www l.yno :tsp sue th la om son fr r Monitoring Monitoring treatment outcomes Monitoring compliance Other Partnership Liaison with the prescribing doctor35,42 with other Referral for patient education42,44 health Referral to a specialist nurse44 professionals Referral for medical advice35,37,44 Abbreviations: HbA1c, glycosylated hemoglobin; SMBG, self-monitoring of blood glucose; T2DM, type 2 diabetes mellitus. with T2DM. Most of the studies have been conducted in developed western countries, particularly the United States of America,19–22 although examples can be found around the globe including the United Arab Emirates23 and Hong Kong.24 Fewer studies however have been conducted in low- and middle-income countries such as Nigeria,25 Iran,26 India,27,28 Brazil,29 Thailand,30 Jordon,31 Iraq,32 and Malaysia.33 The range of interventions evaluated are indicated in Table 2. The interventions were measured for their effectiveness using the following: • • • clinical outcomes, such as glycemic control,29,34–43 reduction of risk factors (such as blood pressure, lipids, and body mass index [BMI]),29,35,42–44 medication adherence,34,38,44–46 screening for complications,43 and drug-related problems identified/solved;35,37,38,42,45 humanistic/social outcomes, such as quality of life,27,35,36,42,47 satisfaction,42,46 belief,45 knowledge,27,37,38,41,42 lifestyle changes,44 and self-care activity;47 economic outcomes, such as health costs.42,43 Blenkinsopp and Hassey48 undertook a systematic review to evaluate the effect of community pharmacy interventions in diabetes (types 1 and 2). They reviewed seven papers, three focused on glycemic control, two on adherence, and one each on patient knowledge and medication problems. Six of the studies demonstrated positive results (Table 3), with two being significant. Components of community pharmacybased interventions which appeared to contribute to effectiveness included the following: patient education/consultation about their diabetes and its treatment, medications, and lifestyle changes; and monitoring/reviewing glycemic control.48 Since that review, there have been several others which are summarized in Table 3. These systematic reviews have covered the impact of pharmacists in a number of settings from hospitals, outpatients clinics, primary (community) health centers, and community pharmacy.19–21,49–51 The results of all of the systematic reviews demonstrate support for the role of pharmacist in diabetes care across the various settings. Collins et al21 reported that HbA1c levels decreased by an average of 0.76% based upon results of 14 trials involving 2,073 subjects and fasting blood glucose by an average 1.63 mmol/L based upon results of four trials involving 589 subjects as compared to control subjects. Aguiar et al19 undertook a meta-analysis of 22 studies which examined the effect of pharmacist interventions on glycemic control in T2DM patients. This analysis demonstrated a statistically and clinically significant reduction in HbA1c of −0.85% (95% confidence interval [CI]: −1.06 to −0.65, P < 0.0001). When community pharmacy interventions were compared to other outpatient settings, the effect on HbA1c was similar (−0.65% vs −0.98%, P = 0.08). Interestingly, overall, the most significant effect on HbA1c was seen in those studies in which participants’ baseline HbA1c was >9%. Further, the benefit derived reduced as the age of the participants increased.19 Likewise, the reviews in Table 3 have demonstrated statistically significant improvements in other clinical outcomes such as reduction in risk factors and improved medication adherence. For example, Santschi et al’s20 meta-analysis demonstrated significant reductions in both systolic blood pressure (SBP) (−6.2 mmHg, 95% CI −7.8 to −4.2) and diastolic blood pressure (DBP) (−4.5 mmHg, 95% CI: −6.2 to −2.8). Six of the 14 studies included in the analysis of SBP involved community pharmacies, with three showing significant falls of between −5.6 mmHg and −20.05 mmHg. 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l av rgu ,G lau il:iltsraavvveenbdooM iii(travceeenndowm =il.f/)ttaceeu0352dM ittsssraacenddoo ,iiiftseenPddRD iilitgagccenunundd ii(ttsrgacceennnnpo l,li,ifttssaayeeeebndd iilf)-tsrrgennooom iiiitragcvennpddoom .il;()sgce0001nnuo% iitssssrgggeenunndoo ittsraceenndooomm iiitsrrgaagcyeenhphnd iiitsagacceennhndom ij.;)(tsganu764d% trraaaycephnhpoom ilfttsssracepbhoooo liliitsssrayveeebhupndo iilltttraacehnbhooow l.()ttraaaceee2h3h3%m iiftttsrrragaeeepnnndo lifttssrraaeeephhhnooo .i,())(ttsgee671nd% lil.ttsssreeeeuhupbhnhdT illi,;ttssaeeeeub2dPdRDm ilii,i;-ttsrgyeeLppnhhndooT li,;ItravceeeLnnuACCHmN o p D ifd y : d t H n s is : ,1 is se , ; o littsaeudo ittsaycem i,vee30w l-tsaaayen 2 ltao iittsraacpn ittsaycem i,vee405w l-tsaaayen ,571 iItsaSnub lli;ts2uTDM liitryeppnoo il,;ffIceoC T s r m 2 T p s r m 2 in e it ty s m sn lia l l d ()1 laeu .)ro tsee -ed qu :itseud ;fftsceeTC iftsraachpm ittsrveennnoo itrcccyenoom :iitttssagehpno iliitttsaccenpun ,i)tycun51omm ,()raayc8hm itsayenbuomm ili)(sac4nnd tsrracceeeehn llt]raaaccveeud l(ttssrraeeunum i,tayep1b1dDM ll,l;tsreeLLoowD ll,-ttraaeeeLhhdo S R o in lg S o ( p c c r t o w n 5 e e 1 i v d ta 0 e n d 2 r /d ,a t ly itacm ilssy ebM spuo (tsra Jtuo te an uP cS :s p :isssgyn -taaem :ssaaeb ,IeLDN sc tracehd i)veudd e nd ta e lia ae ro D a D M L S p e o Q [ v ts iit l;T ch R cek spo itra lta ;xH rab ed lled ,toC iend e w o T ss ra ho tr ; a u s n e o r m q h c su y s c i d s d in h e re o ith rw iz p ,Ib w e m d b o o M n m nd lo ;B w u a b e o n r sh e , ilc cn lsaeu tahnd RTC: itsado iffreed v ) sn ,P an e r o B e h to i t T a D m n ia ; *: i m ve re d s u te e o r s h t n b s g o e b re ie N (d A p w Integrated Pharmacy Research and Practice 2017:6 23 submityourmanuscript|www.dovepress.com Dovepress Significant reductions were also reported for total cholesterol, low-density lipoprotein cholesterol, and BMI. Despite significant variations in the methods by which adherence was measured, pharmacist interventions were generally shown to have a positive effect, although it was 8 unclear in many instances what impact the improvement had l-201 on clinical outcomes.50 Patients’ knowledge of their disease -J2u and its complications, its treatment (pharmacological and 1n non-pharmacological), and self-monitoring has also been 53o shown to be increased through pharmacist-delivered educa.415 tional interventions.51 .532 The ability to demonstrate improvements in the quality .51 of life of people with diabetes is often hampered by the short /yb duration of the studies, and the tools chosen. Despite these .com factors, pharmacist-managed interventions again showed rsse positive benefits. Limited studies have investigated the ecovpoe nomic benefits of pharmacist interventions in diabetes care. .d A recent meta-analysis by Wang et al,22 which included 25 //www l.yno studies, reported that “pharmacist-managed services had :tsp sue a positive return in terms of economic viability”. Ten of thom lsaon the 25 studies were completed in community pharmacy. fr r Benefits demonstrated included that the average cost of a ldedao rpeoF 1% reduction in HbA1c was US$174 per person; such a nw reduction translates into a 21% reduction in macrovascular deo complications. Further, whilst pharmacist interventions often itcc increased medication costs, these costs were offset by a reducradanP taitotennidnamnceedsicaanldchoostsspaitsasloizcaiatitoend.w22 iItnhfeamcte,rcgoemncpyardeedptaortumseunatl rcha care, pharmacist-led services produced cost savings in the see range of US$8 to $85,000 per year, whilst costing between cyR US$62,803 and US$114,576 to prevent one diabetes-related raam macrovascular and microvascular event. Of the six studies hP that included cost–benefit analysis (cost-to-benefit ratio ttrdeage rbaansgede w1:e1r–e8e.i5th:1e)r,ctohset tnherueterathl(a1t:w1)e5r2eorcocomsmteufnfeitcytivpeha(6rm.1a:1c5y3 In and 8.5:154). Hendrie et al55 evaluated the economic benefit of reduced glycemic events (hypo- and hyperglycemia) in a group of patients who enrolled into a 6-month Diabetes Management Education Program (DMEP). They found that the intervention resulted in significantly greater reductions in the number of hyper- and hypoglycemic events relative to the control group (odds ratio [OR] 0.34, 95% CI 0.22–0.52, P = 0.001 vs OR 0.54, 95% CI 0.34–0.86, P = 0.009). This reduction translated into a net reduction of 1.86 days with glycemic episodes per patient per month. In terms of costeffectiveness, the DMEP costs AU$43 (US$39) per day of glycemic symptoms avoided relative to standard care. In summary, to date, pharmacist interventions to improve the care of patients with diabetes, and in particular those with 24 submit your manuscript | www.dovepress.com Dovepress T2DM, have been shown to deliver positive clinical, humanistic, and economic benefits. However, the interventions, which are often multifaceted, have varied across studies, although often education- and clinical review-based, making it difficult to determine which elements deliver the greatest benefits. Future roles for pharmacists in T2DM management To date, evidence supports pharmacists extending their role in diabetes care from medication supply to cognitive services which aim to assist those with diabetes achieve the best possible clinical outcomes through supporting their self-management. Realistically, pharmacists potentially have a role to play in all facets of the care of T2DM patients as depicted in Figure 1. However, widespread implementation of such services in the future will depend on legislative change, adequate funding (government and nongovernment), professional commitment, interprofessional collaboration, and consumer (patient) acceptance. The importance of the latter should not be underestimated, with recent work again illustrating that consumers do not perceive community pharmacies as a place to go to get assistance with their diabetes care. Consumers are happy to accept that pharmacists can provide them with medications and counseling; however, they have consistent concerns about the knowledge and competency of pharmacists to provide additional services, and that community pharmacies are a suitable environment to deliver them.56 The findings of Dhippayom and Krass57 support this, with participants in their study highlighting the main role of pharmacists is medication provision, with some enhancements in supporting adherence and continuity of supply. Therefore, for community pharmacy-based services to succeed, these perceptions must be changed; this will require action from within the pharmacy profession through further training, establishment of private consulting areas, changes to workflows, and proactively promoting pharmacists’ capability to deliver enhanced diabetes care. Delivery of such services within other settings such as hospitals, outpatient clinics, and community-based clinics is likely to be better received by patients, with pharmacists being seen more as a care provider than a supplier of medicines. Evidence supports pharmacists working in these settings, either directing care or collaborating in care.20 Targeting of services to those at greatest need would seem appropriate, such as patients with newly diagnosed diabetes56 who are often overwhelmed by the diagnosis and have a poor understanding of its management. For example, general practitioners often fail to provide adequate education Integrated Pharmacy Research and Practice 2017:6 8 1 0 2 l u J 2 1 n o 3 5 1 . 4 5 2 . 5 3 1 . 5 y b / m o c . s s e r p e v o d . n w o d e c it c a r P d n a h c r a e s e R y c a m r a h P d e t a r g e t n I ldedao rpeoF for patients starting oral hypoglycemics, and community pharmacists are well placed to fulfill this role. Further, the evidence suggests that patients with poorly managed diabetes, that is, those with HbA1c > 9 mmol/L,19 gain the greatest benefit from pharmacist interventions, suggesting targeting such patients would be appropriate. This could be facilitated through referrals from medical practitioners or pharmacists ordering of HbA1c levels or point-of-care testing. Funding to deliver pharmacy-based cognitive services is a contentious issue, and whilst they can be funded through a user-pays model, government-funded or third-party payer models are likely to be needed for widespread implementation of such services. For example, depending on the level of remuneration, one would envisage that a limited number of community pharmacies specializing in diabetes would offer extended services. Legislative change to allow pharmacists to manage patients’ diabetes therapy either in consultation with their primary health provider or independently, which has occurred in some jurisdictions, will allow pharmacists delivering such services to have greater impact. Diabetes screening is another area of significant need which pharmacists should engage in as many people living with the disease are undiagnosed. A large-scale trial is about to commence in Australia to evaluate community pharmacists’ role in diabetes screening. This study builds upon the work of Krass et al,58 which demonstrated that a sequential screening program, that is, tick test followed by capillary blood glucose testing, was an effective means to detect prediabetic and diabetic patients. Conclusion There is significant evidence to support the role of pharmacists in providing a range of extended diabetes care services, from the screening to ongoing disease state management. However, despite this, the provision of such services generally remains limited and inconsistent. However, this is set to change, as the number of people with T2DM grows, and the capacity of traditional care providers to cope with these people diminishes. Governments, third-party payers, and consumers will all be looking for cost-effective ways to manage diabetes. Pharmacists are ideally placed to assist patients with their diabetes management within a range of clinical settings as demonstrated by current evidence. Needed now are models of practice which are evidence based, consistent, and scalable, such that they deliver the outcomes desired by all stakeholders. Disclosure The authors report no conflicts of interest in this work. Integrated Pharmacy Research and Practice 2017:6 Role of the pharmacist in the management of T2DM submit your manuscript | www.dovepress.com Dovepress 25 8 1 0 2 l u J 2 1 n o 3 5 1 . 4 5 2 . 5 3 1 . 5 y b / m o c . s s e r p e v o d . ldedao rpeoF n w o d e c it c a r P d n a h c r a e s e R y c a m r a h P d e t a r g e t n I PowerdbyTCPDF(w w.tcpdf.org) submit your manuscript | www.dovepress.com Dovepress Integrated Pharmacy Research and Practice 2017:6 Publish your work in this journal Integrated Pharmacy Research and Practice is an international, peer-reviewed, open access, online journal, publishing original research, reports, reviews and commentaries on all areas of academic and professional pharmacy practice. This journal aims to represent the academic output of pharmacists and pharmacy practice with particular focus on integrated care. 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Jeffery David Hughes, Yosi Wibowo, Bruce Sunderland, Kreshnik Hoti. The role of the pharmacist in the management of type 2 diabetes: current insights and future directions, Integrated Pharmacy Research and Practice, 2017, 15-27, DOI: 10.2147/IPRP.S103783