Recovery after cardiac arrest: the brain is the heart of the matter

Netherlands Heart Journal, Sep 2018

J. Hofmeijer, M. E. W. Hemels

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Recovery after cardiac arrest: the brain is the heart of the matter

Netherlands Heart Journal October 2018, Volume 26, Issue 10, pp 484–485 | Cite as Recovery after cardiac arrest: the brain is the heart of the matter AuthorsAuthors and affiliations J. HofmeijerM. E. W. Hemels Open Access Commentary First Online: 06 September 2018 525 Downloads Since the 1990s, survival rates of out-of-hospital cardiac arrest have increased considerably in the Netherlands, from 16% in 2006 to 23–27% in 2016, to even 41% in patients with a shockable rhythm. In comparison, survival after cardiac arrest in the USA was 12% in 2016 [1, 2]. The exemplary increase in survival in the Netherlands is related to national programmes aimed at increasing awareness of signs of cardiac arrest, providing education on basic life support to the general population, and making available dense networks of automated external defibrillators throughout the country [1, 2]. The Dutch Heart Foundation (Hartstichting) has formulated the criteria for so-called ‘6-minute zones’ to save an additional 2,500 lives per year [3]. In sharp contrast with increased survival after cardiac arrest, neurological outcome has changed only marginally over the past decades. Of those surviving up to hospital admission, more than three-quarters initially remain comatose as a result of diffuse anoxic-ischaemic brain damage. Half of comatose patients die in hospital. Disturbances of motor function, cognition, mood, or other neurological impairments have been found in up to 100% of survivors [4, 5]. Cognitive impairments are strongly related to reduced quality of life [6]. Rates of mortality, anxiety, and depression appear to be higher in women than in men [2, 4]. Early recognition of disturbances of motor function, cognition or mood would allow better guidance of patients, and open avenues for targeted treatments. Accordingly, both the Dutch and the European Resuscitation Council guidelines for cardiac rehabilitation recommend screening for cognitive impairments and cognitive rehabilitation [7]. However, in patients that wake up from a coma, diagnosis and treatment are focused on cardiac function, while brain damage and neurological impairments are addressed infrequently and not systematically. Protocols to diagnose cognitive and subsequent functional impairments are scarce. There are no effective treatments to promote recovery of brain function and improve neurological outcome [8]. In this issue of the Netherlands Heart Journal, Boyce and co-workers assess the acceptance of the guideline recommendations amongst Dutch cardiologists and rehabilitation specialists, as well as their current implementation, by means of questionnaires [9]. The vast majority of responders acknowledged the importance of cognitive screening in cardiac arrest survivors, including the need for clear protocols. However, only a minority reported actual implementation of a cognitive screening protocol in their clinic. In addition, the authors analysed barriers to and success factors for implementation. They established the following barriers: lack of knowledge of cognitive disturbances amongst cardiologists, logistic and financial problems (that unfortunately were not further described), poor collaboration between cardiac and cognitive rehabilitation specialists, relatively small numbers of patients in some hospitals, and fear of administrative overload. Many respondents saw opportunities to implement protocols for the diagnosis and treatment of cognitive disturbances. These include more personalised treatment and a consequent decrease of drop-outs during the cardiac rehabilitation programme. We underscore the importance of brain damage after cardiac arrest and compliment Boyce and co-workers for their efforts to draw attention to this. It is our strong opinion that, after successful programmes to increase survival rates, we now have the responsibility to build on the growing evidence of cognitive and emotional impairments to improve neurological and psychiatric diagnosis and treatment. We will have to develop and implement a rational approach for the identification of brain damage, and to test rehabilitation treatments to promote functional recovery. Until further evidence becomes available, screening for cognitive impairments may be performed using the Montreal Cognitive Assessment, which takes a trained nurse just 10 min [9]. In the presence of relevant cognitive disturbances, cardiac rehabilitation may include psycho-education and strategy training. In this way, even a little effort may result in significant improvement of patient-oriented rehabilitation of survivors after cardiac arrest. References 1. Husain S, Eisenberg M. Police AED programs: a systematic review and meta-analysis. Resuscitation. 2013;84:1184–91.CrossRefPubMedGoogle Scholar 2. Hartstichting. Reanimatie in Nederland. Cijfers over overleving na hartstilstand buiten het ziekenhuis. 2016.Google Scholar 3. https://www.hartstichting.nl/reanimatie/6-minutenzone. 4. Green CR, Botha JA, Tiruvoipati R. Cognitive function, quality of life and mental health in survivors of out-of-hospital cardiac arrest: a review. Anaesth Intensive Care. 2015;43:568–76.PubMedGoogle Scholar 5. Moulaert VRMP, Verbunt JA, van Heugten CM, Wade DT. Cognitive impairments in survivors of out-of-hospital cardiac arrest: a systematic review. Resuscitation. 2009;80:297–305.CrossRefPubMedGoogle Scholar 6. Moulaert VRMP, Wachelder EM, Verbunt JA, Wade DT, van Heugten CM. Determinants of quality of life in survivors of cardiac arrest. J Rehabil Med. 2010;42:553–8.CrossRefPubMedGoogle Scholar 7. Nolan JP, Soar J, Cariou A, et al. European Resuscitation Council and European Society of Intensive Care Medicine 2015 guidelines for post-resuscitation care. Intensive Care Med. 2015;41:2039–56.CrossRefPubMedGoogle Scholar 8. Nielsen N, Wetterslev J, Cronberg T, et al. Targeted temperature management at 33°C versus 36°C after cardiac arrest. N Engl J Med. 2013;369:2197–206.CrossRefPubMedGoogle Scholar 9. Boyce LW, Goossens PH, Volker G, Exel HJ van, Vliet-Vlieland TPM, Bodegom-Vos L van. Attention needed for cognitive problems in patients after out of hospital cardiac arrest: an inventory about daily rehabilitation care. Neth Heart J. 2018.  https://doi.org/10.1007/s12471-018-1151-z. Copyright information © The Author(s) 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Authors and Affiliations J. Hofmeijer12Email authorM. E. W. Hemels341.Department of NeurologyRijnstate HospitalArnhemThe Netherlands2.Clinical Neurophysiology, Technical Medical CenterUniversity of TwenteEnschedeThe Netherlands3.Department of CardiologyRijnstate HospitalArnhemThe Netherlands4.Department of CardiologyRadboud University Medical CenterNijmegenThe Netherlands


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J. Hofmeijer, M. E. W. Hemels. Recovery after cardiac arrest: the brain is the heart of the matter, Netherlands Heart Journal, 2018, 484-485, DOI: 10.1007/s12471-018-1156-7