Contribuição ao estudo da patologia da lepra murina

Memórias do Instituto Oswaldo Cruz, Feb 2019

The A. reviewed the bibliography of pathology of murine leprosy. Out of 41 rats expontaneously infected with murine leprosy 39% had alopecia, especially on the back; 78% had subcutaneous infiltrations; 13 of them presented tumour-like grows, sometimes large as 5 cm. of diameter; eight animals had ulcerations varying from 1 to 15 in number; 11 had skin nodules; two presented splenomegaly and two others small nodules upon the surface of the spleen; five had microabcesses on the liver; two had pneumonia and two others showed microcabcesses on their lungs. The other organs were macroscopically normals. Histopathological studies were made with materials of natural and experimental rat leprosy disease. Granulomata were seen on sections of their skins, lumph nodes, spleens, bone marrows, livers, lungs and kidneys. The testicles were rarely envolved. The granulomatous tissues are formed by mononuclear cells or by large plae cells resembling epithelioid celss, in which there were numerous bacilli. The infections process become localisated by long time in the lumph nodes. Rat leprosy by its nature and probably origin of the affected cells suggest a primordially disease of the reticulo-endothelial system.

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Contribuição ao estudo da patologia da lepra murina

Contribuição ao estudo da patologia da lepra murina Herminio Linhares RESUMO O A. fez a revisão bibliográfica sobre a patologia da lepra murina. Em 41 ratos espontaneamente infectados com lepra murina 39% tinham alopecia, especialmente no dorso; 78% tinham infiltração subcutânea; 13 apresentavam tumores que podiam atingir 5 cm. de maior diâmetro; oito animais tinham ulcerações variando em número de 1 a 15; 11 tinham nódulos, desde um desde um único até 10; dois apresentavam hipertrofia do baço e dois outros tinham pequenos nódulos na sua superfície; microabcessos no fíagado em cinco casos; dois ratos com pneumonia e dois outros com microabcessos no pulmão. Os demais orgãos estavam macroscopicamente normais. Foram feitos minuciososestudos histopatológicos com material de lepra murina espontânea e experimental. Granulomas foram vistos em cortes da pele, gânglios linfáticos, baço, médula óssea, fígado, pulmões e rins. os testículos estavam raramente atingidos. Os granulomas são constituidos por células mononucleares ou por grandes células semelhantes ás células epitelioides, nas quais existem numerosos bacilos. O processo infeccioso fica localizado por muito tempo nos gãnglios linfáticos. A lepra murina por sua natureza e provavel origem das células atingidas sugere ser uma doença primoedial do sistema retículo endotelial. ABSTRACT The A. reviewed the bibliography of pathology of murine leprosy. Out of 41 rats expontaneously infected with murine leprosy 39% had alopecia, especially on the back; 78% had subcutaneous infiltrations; 13 of them presented tumour-like grows, sometimes large as 5 cm. of diameter; eight animals had ulcerations varying from 1 to 15 in number; 11 had skin nodules; two presented splenomegaly and two others small nodules upon the surface of the spleen; five had microabcesses on the liver; two had pneumonia and two others showed microcabcesses on their lungs. The other organs were macroscopically normals. Histopathological studies were made with materials of natural and experimental rat leprosy disease. Granulomata were seen on sections of their skins, lumph nodes, spleens, bone marrows, livers, lungs and kidneys. The testicles were rarely envolved. The granulomatous tissues are formed by mononuclear cells or by large plae cells resembling epithelioid celss, in which there were numerous bacilli. The infections process become localisated by long time in the lumph nodes. Rat leprosy by its nature and probably origin of the affected cells suggest a primordially disease of the reticulo-endothelial system. Texto completo disponível apenas em PDF. Full text available only in PDF format.


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Herminio Linhares. Contribuição ao estudo da patologia da lepra murina, Memórias do Instituto Oswaldo Cruz, 543-581, DOI: 10.1590/S0074-02761942000400003