A High-Sensitivity and Broad-Range SPR Glucose Sensor Based on Improved Glucose Sensitive Membranes

Photonic Sensors, Mar 2019

An improved glucose sensitive membrane (GSM) is prepared by immobilizing glucose oxidase (GOD) onto a mixture of silica mesocellular foams (SiMCFs) and SiO2 nanoparticles (SiNPs) and then trapping it in a polyvinyl alcohol (PVA) gel. The membrane is coated onto a gold-glass sheet to create a surface plasmon resonance (SPR) sensor. A series of experiments are conducted to determine the optimized parameters of the proposed GSM. For a GSM with a component ratio of SiMCFs: SiNPs = 7: 3 (mass rate), the resonance angle of the sensor decreases from 68.57° to 63.36°, and the average sensitivity is 0.026°/(mg/dL) in a glucose concentration range of 0 mg/dL‒200 mg/dL. For a GSM with a component ratio of SiMCFs: SiNPs = 5: 5 (mass rate), the resonance angle of the sensor decreases from 67.93° to 63.50°, and the sensitivity is 0.028°/(mg/dL) in a glucose concentration range of 0 mg/dL‒160 mg/dL. These data suggest that the sensor proposed in this study is more sensitive and has a broader measurement range compared with those reported in the literature to date.

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A High-Sensitivity and Broad-Range SPR Glucose Sensor Based on Improved Glucose Sensitive Membranes

Photonic Sensors pp 1–8 | Cite as A High-Sensitivity and Broad-Range SPR Glucose Sensor Based on Improved Glucose Sensitive Membranes AuthorsAuthors and affiliations Yinquan YuanNa YuanDejing GongMinghong Yang Open Access Regular First Online: 01 March 2019 26 Downloads Abstract An improved glucose sensitive membrane (GSM) is prepared by immobilizing glucose oxidase (GOD) onto a mixture of silica mesocellular foams (SiMCFs) and SiO2 nanoparticles (SiNPs) and then trapping it in a polyvinyl alcohol (PVA) gel. The membrane is coated onto a gold-glass sheet to create a surface plasmon resonance (SPR) sensor. A series of experiments are conducted to determine the optimized parameters of the proposed GSM. For a GSM with a component ratio of SiMCFs: SiNPs = 7: 3 (mass rate), the resonance angle of the sensor decreases from 68.57° to 63.36°, and the average sensitivity is 0.026°/(mg/dL) in a glucose concentration range of 0 mg/dL‒200 mg/dL. For a GSM with a component ratio of SiMCFs: SiNPs = 5: 5 (mass rate), the resonance angle of the sensor decreases from 67.93° to 63.50°, and the sensitivity is 0.028°/(mg/dL) in a glucose concentration range of 0 mg/dL‒160 mg/dL. These data suggest that the sensor proposed in this study is more sensitive and has a broader measurement range compared with those reported in the literature to date. KeywordsSurface plasmon resonance sensor glucose sensitive membrane immobilized enzyme silica mesocellular foams  Download to read the full article text Notes Acknowledgement This work was funded by the National Natural Science Foundation of China (Grant No. 61575151). References [1] B. B. Luo, Z. J. Yan, Z. Y. Sun, Y. Liu, M. F. Zhao, and L. Zhang, “Biosensor based on excessively tilted fiber grating in thin-cladding optical fiber for sensitive and selective detection of low glucose concentration,” Optics Express, 2015, 23(25): 32429–32440.ADSCrossRefGoogle Scholar [2] A. Deep, U. Tiwari, P. 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Wang, “Development of boronic acid grafted random copolymer sensing fluid for continuous glucose monitoring,” Biomacromolecules, 2008, 10(1): 113–118.CrossRefGoogle Scholar Copyright information © The Author(s) 2019 >Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Authors and Affiliations Yinquan Yuan1Email authorNa Yuan1Dejing Gong1Minghong Yang1Email author1.National Engineering Laboratory for Fiber Optic Sensing TechnologyWuhan University of TechnologyWuhanChina


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Yinquan Yuan, Na Yuan, Dejing Gong, Minghong Yang. A High-Sensitivity and Broad-Range SPR Glucose Sensor Based on Improved Glucose Sensitive Membranes, Photonic Sensors, 2019, 1-8, DOI: 10.1007/s13320-019-0538-9