CMR feature tracking in Kawasaki Disease convalescence
Journal of Cardiovascular Magnetic Resonance ,
Feb 2015
Konstantinos Bratis , Pauline Hackmann , Nicholas Child , Sophie Mavrogeni , Thomas Krasemann , Tarique Hussain , Rene Botnar , Reza Razavi , Gerald F Greil
CMR feature tracking in Kawasaki Disease convalescence
Volume 17 Supplement 1
Abstracts of the 18th Annual SCMR Scientific Sessions
Poster presentation Open Access
CMR feature tracking in Kawasaki Disease convalescence
Konstantinos Bratis1, Pauline Hackmann1, Nicholas Child1, Sophie Mavrogeni2, Thomas Krasemann3, Tarique Hussain1, Rene Botnar1, Reza Razavi1 and Gerald F Greil1
Journal of Cardiovascular Magnetic Resonance201517 (Suppl 1) :P366
https://doi.org/10.1186/1532-429X-17-S1-P366
© Bratis et al; licensee BioMed Central Ltd. 2015
Published: 3 February 2015
Keywords
Kawasaki DiseaseLeft Ventricular Systolic FunctionKawasaki Disease PatientNormal Left Ventricular Systolic FunctionCoronary Artery Involvement
Background
Myocardial inflammation has been described as a global finding in the acute phase of Kawasaki Disease. Despite normal LV systolic function by routine functional measurements, reduced longitudinal strain (S) and strain rate (SR) have been detected by echocardiography in the acute phase, which may potentially predict late onset heart failure.
We aimed to determine whether left ventricular (LV) myocardial deformation indices can detect subclinical myocardial abnormalities in Kawasaki Disease (KD) convalescence. We hypothesized that subclinical myocardial abnormalities due to inflammation represent an early manifestation of the disease that persist in convalescence.
Methods
Peak systolic LV myocardial longitudinal, radial and circumferential S and SR (Figure 1) were examined in 29 KD convalescent patients (15 males; mean (SD) age 11 (6.6) years, range 3- 27 years; median interval from KD onset 5.8 (5.4) years) and 10 healthy volunteers (5 males; mean age 14 (3.8) years, range 6- 19 years) with the use of cardiac magnetic resonance feature tracking (CMR-FT). Routine indices of LV systolic function were normal in both groups.
Figure 1
CMR-FT post-processing. Short-axis apical (1), mid ventricular (2), basal (3) and 4-chamber long-axis (4) views with relevant endocardial contour drawn in a KD patient. Radial strain (A) and strain rate (B), circumferential strain (C) and strain rate (D) and longitudinal strain and strain rate (4, mid and lower row, respectively) results are provided below each slice. CMR-FT: Cardiac Magnetic Resonance Feature Tracking, KD: Kawasaki Disease
Results
Comparisons were made between normal controls and (i) the entire KD group, (ii) KD group subdivided by coronary artery involvement. (Table 1) Compared to controls, KD patients had lower longitudinal S. Average longitudinal and circumferential S at all levels was lower in KD patients compared normal controls. In subgroup analysis, both KD patients with and without any history of CAD had similar longitudinal and circumferential S at all levels and lower when compared against controls. There was a non-significant trend for lower circumferential and longitudinal values in KD patients with persisting CAD when compared against those with regressed CAD.
Table 1
Longitudinal, radial and circumferential global LV deformation analysis of KD patients and KD subgroups compared with controls.
Controls (n=10)
All KD (n=27)
KD with CAL
KD without CAL (n=5)
All (n=22)
Persistent CAL (n=13)
Regressed CAL (n=9)
Basal radial
Strain
28.2 (13.9)
31.2 (8.3)
31.8 (8.6)
30.3 (8.0)
34.1 (9.0)
26 (3.2)
Strain rate
1.4 (0.4)
1.6 (0.7)
1.7 (0.8)
1.6 (0.9)
1.7 (0.6)
1.3 (0.2)
Basal circumferential
Strain
28.2 (13.9)
23.7 (5.5)
23.1 (4.9)
22.0 (4.7)
24.9 (5.7)
23.1 (4.7)
Strain rate
1.4 (0.4)
1.5 (0.4)
1.5 (0.4)
1.5 (0.5)
1.5 (0.4)
1.3 (0.3)
Mid radial
Strain
29.0 (7.3)
30.5 (8.1)
30.1 (5.3)
31.1 (5.2)
31.9 (11.4)
28.2 (7.7)
Strain rate
1.6 (0.2)
1.7 (0.8)
1.7 (0.8)
1.7 (1.0)
1.7 (0.5)
1.3 (0.3)
Mid circumferential
Strain
23.8 (2.8)
21.1 (5.5)
21.0 (5.4)
20.9 (4.1)
22.2 (7.0)
21.9 (6.9)
Strain rate
1.7 (0.3)
1.4 (0.5)
1.4 (0.5)
1.4 (0.4)
1.5 (0.6)
1.3 (0.5)
Apical radial
Strain
11.7 (2.8)
14.9 (7.4)
16.3 (6.0)
15.6 (6.3)
17.3 (5.7)
17.0 (8.6)
Strain rate
1.8 (0.7)
1.4 (0.7)
1.4 (0.6)
1.5 (0.8)
1.4 (0.3)
1.3 (0.8)
Apical circumferential
Strain
24.9 (6.2)
21.7 (7.0)
22.0 (7.4)
21.0 (7.6)
24.5 (8.5)
17.4 (4.0)
Strain rate
1.9 (0.6)
1.6 (0.6)
1.6 (0.6)
1.6 (0.6)
1.8 (0.7)
1.4 (0.1)
Longitudinal
Strain
18.9 (7.8)
16.4 (5.4)
17.2 (4.9)
16.2 (4.5)
18.8 (5.4)
12.8 (6.8)
KD: Kawasaki Disease, CAL: Coronary Artery Lesion, *: p < 0.05
Conclusions
In this CMR-FT study in KD convalescent patients with preserved conventional functional indices, we observed a trend for lower circumferential and longitudinal strain in KD patients compared to normal controls, irrespective of their coronary artery status.
Funding
The authors acknowledge financial support from the Department of Health through the National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre award to Guy's & St Thomas' NHS Foundation Trust in partners (...truncated)
This is a preview of a remote PDF: https://jcmr-online.biomedcentral.com/track/pdf/10.1186/1532-429X-17-S1-P366
Konstantinos Bratis, Pauline Hackmann, Nicholas Child, Sophie Mavrogeni, Thomas Krasemann, Tarique Hussain, Rene Botnar, Reza Razavi, Gerald F Greil.
CMR feature tracking in Kawasaki Disease convalescence ,
Journal of Cardiovascular Magnetic Resonance,
2015, pp. P366, Volume 17, Issue 1, DOI: 10.1186/1532-429X-17-S1-P366