Profile and outcomes of patients with acute complications of malaria presenting to an urban emergency department of a tertiary hospital in Tanzania

BMC Research Notes, Jun 2019

In Tanzania, malaria ranks number three among the top ten causes of deaths in all age groups, however little is known about the utilisation of emergency department by patients with complications of malaria. We describe clinical presentation, resource utilization, and outcomes of acutely ill patients with complications of malaria presenting to an urban emergency department (ED) in Tanzania. We screened 405 patients which physicians had a clinical suspicion or diagnosis of malaria at ED. We enrolled 184 (45.5%) patients meeting WHO clinical and laboratory definition of malaria. The median age was 22 years (interquartile range 22–33 years), 105 (57%) were male, and overall 124 (67.4%) were self-referral. The use of insecticide treated nets (ITNs) in this group was 125 (67.4%). Fever 125 (67.9%), headache 56 (30.4%) and general body malaise 41 (22.2%) were the top three frequent complains, while tachycardia 83 (42.9%) was the most frequent abnormal vital sign. Overall, 21 (11.4%) patients had severe anaemia and 21 (11.4%) had abnormal renal function test. In ED 121/184 (65.8%) patients received antimalarial, 74/184 (40.2%) received antibiotics, 6/184 (3.3%) received antipyretic/analgesic and 5/20 (25%) patients with severe anaemia received blood transfusion. Overall, 99/184 (53.8%) patients were hospitalized, 3 (1.6%) died at the ED, and the overall hospital morality was 3.8%. Overall we found a substantial burden of patients with complications of malaria presenting in the largest public ED in Tanzania.

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Profile and outcomes of patients with acute complications of malaria presenting to an urban emergency department of a tertiary hospital in Tanzania

Research note Open Access Profile and outcomes of patients with acute complications of malaria presenting to an urban emergency department of a tertiary hospital in Tanzania Raya Yusuph1, 2Email author, Hendry R. Sawe1, 2, Paulina N. Nkondora1, 2 and Juma A. Mfinanga1, 2 BMC Research Notes201912:345 https://doi.org/10.1186/s13104-019-4388-8 ©  The Author(s) 2019 Received: 12 March 2019Accepted: 13 June 2019Published: 18 June 2019 Abstract Objectives In Tanzania, malaria ranks number three among the top ten causes of deaths in all age groups, however little is known about the utilisation of emergency department by patients with complications of malaria. We describe clinical presentation, resource utilization, and outcomes of acutely ill patients with complications of malaria presenting to an urban emergency department (ED) in Tanzania. Results We screened 405 patients which physicians had a clinical suspicion or diagnosis of malaria at ED. We enrolled 184 (45.5%) patients meeting WHO clinical and laboratory definition of malaria. The median age was 22 years (interquartile range 22–33 years), 105 (57%) were male, and overall 124 (67.4%) were self-referral. The use of insecticide treated nets (ITNs) in this group was 125 (67.4%). Fever 125 (67.9%), headache 56 (30.4%) and general body malaise 41 (22.2%) were the top three frequent complains, while tachycardia 83 (42.9%) was the most frequent abnormal vital sign. Overall, 21 (11.4%) patients had severe anaemia and 21 (11.4%) had abnormal renal function test. In ED 121/184 (65.8%) patients received antimalarial, 74/184 (40.2%) received antibiotics, 6/184 (3.3%) received antipyretic/analgesic and 5/20 (25%) patients with severe anaemia received blood transfusion. Overall, 99/184 (53.8%) patients were hospitalized, 3 (1.6%) died at the ED, and the overall hospital morality was 3.8%. Overall we found a substantial burden of patients with complications of malaria presenting in the largest public ED in Tanzania. Keywords Malaria complicationsEmergency departmentAfricaTanzania Introduction Malaria is still a major health problem across the lower and middle income countries accounting for up to 40% of public expenditure in Africa [1]. In Africa about 300–500 million people suffer from malaria, of which millions of them progress to severe malaria. The Sub-Saharan Africa (SSA) is particularly most affected with malaria endemic, with estimates of 88% of global cases, mostly affecting children below the age of 5-years and pregnant women [2]. In Tanzania, as in other SSA countries, malaria is among the top health problems, affecting particularly the children below age of 5-years and pregnant women. Over 90% of the population in Tanzania lives in Malaria zones, and 60% of the country population lives in the malaria endemic zones [3, 4]. In Tanzania, malaria ranks number three among the top 10 causes of deaths in all age groups, but with as significant effect in children under the age of five, accounting for up to mortality rate of 48/1000 live birth in this age group [5]. The complications of malaria, including but not limited to hypoglycemia, anemia, acute kidney injury (AKI), acidosis, sepsis, hypoxia, shock, disseminated intravascular coagulopathy (DIC), respiratory distress and cerebral malaria have all been associated with poor outcomes [6]. In Tanzania most of health facilities lack the necessary resources to properly diagnose and manage acute malaria complication, some of the facilities lack basic laboratory tests to determine the acute complication of malaria [7] and this have caused the providers to rely mostly on the based on history and other clinical presentation, which may not be reliable in diagnosing the early acute complication of malaria, and hence most often patients presents or are referred late with irreversible complication of malaria [8]. The establishment of a full capacity Emergency Medicine Department at Muhimbili National Hospital (EMD-MNH) in Dar es salaam, Tanzania has provided an opportunity to improve and standardize care in the management of critically ill patients including acute complication of malaria. While most of these patients present in a critically ill stage and requires emergency interventions to abate death and improve long-term morbidity, the exact burden and outcome of patients with complications of malaria presenting to EMD remains unknown. We aimed to describe clinical presentation, resource utilization, and outcomes of acutely ill patients with complications of malaria presenting to an urban EMD in Tanzania. Main text Methods Study design This prospective study enrolled a consecutive sample of patients presenting to the EMD-MNH in Dar es salaam, Tanzania from 1 January 2017 to 31 September 2017. Study setting The EMD is a full capacity acute public emergency department of Muhimbili National Hospital (MNH), the National referral hospital located in Dar es Salaam, the commercial city of Tanzania. MNH has a 1500 bed capacity, receives an average of 1000–1200 outpatients per day, and the EMD has an annual volume of approximately 60,000 patients [9]. The department was opened in 2010, and is staffed by locally trained emergency medicine physicians who oversee care provided by medical officers, interns and residents. The department severs as the teaching unit for the only emergency medicine residency program in Tanzania [10]. Study protocol The study investigator and research assistant prospectively screened and enrolled eligible patients using an electronic structured data sheet to record study information, including demographics, clinical presentation, management and EM diagnosis and final disposition. We followed up each patient to final hospital disposition, and recorded length of hospital stay, need for intensive care unit (ICU) or high dependency unit, final hospital diagnosis and clinical outcome (discharge or death). Data analysis Data from hand-written case report forms were transferred to Excel spreadsheet (Microsoft Corporation, Redmond, WA, USA), and imported to IBM SPSS Statistics v 23 for analysis. Demographic data is summarized by means and standard deviation (SD), we used Chi-square test to compare categorical variables, and Mann–Whitney U-test for comparison of continuous variables. In both comparisons, a two-tailed p-values of < 0.05 was considered statistically significant. Results We screened 405 (100%) patients who were clinically diagnosed to have malaria at EMD-MNH by the treating physician. Among 405 patients, 132 (32.5%) tested positive for malaria (using either rapid diagnostic test or blood slide for malaria). In those who tested negative, 52 (19.4%) presented with at least one feature of severe malaria as defined by the WHO and National guidelines (Additional file 1: Figure S1). Patient demographics Among 405 patients screened, 184 (45.4%) were followed up (this includes 132 who tested positive for malaria, and 52 who tested negative for malaria but had at least features of severe malaria hence meeting the indication for initial malaria treatment). Among those followed up, 105 (57.1%) were male, and the overall median age was 22 years [interquartile range (IQR) of 22–32 years]. Overall 124 (67.4%) were self-referral from home, and the ITNs use among these patients was 125 (67.4%) (Table 1). Table 1 Patient demographics Demographics Number N = 184 Percentage n % Sex  Female 79 42.9  Male 105 57.1 Age group  1 month to < 1 year 13 7.1  1 year to < 5 years 29 15.8  5 years to < 18 years 24 13.0  18 years to < 60 years 111 60.3  ≥ 60 years 7 3.8 ITN use 125 67.9 Referral status  Self referral 124 67.4  Referred 59 32.1  Missing 1 0.5 Clinical characteristics n (%) 95% CI Vital signs  Tachycardiab 83 (45.1) 38.1–52.3  Febrile (T > 37.5 °C)a 71 (38.6) 31.9–45.8  Tachypneab 56 (30.4) 24.2–37.4  Bradycardiab 3 (1.6) 5.6–4.7  Altered mental status 6 (3.2) 1.5–6.9  SpO2 < 91% 8 (4.3) 2.2–8.4 Presenting complaints  Fever 125 (67.9) 60.9–74.3  Headache 56 (30.4) 24.2–37.4  General body malaise 41 (22.3) 16.9–28.8  Cough 15 (8.2) 5.0–13.0  Vomiting 44 (23.9) 18.3–30.6  Abdominal pain 13 (7.1) 4.2–11.7  Diarrhoea 14 (7.6) 4.6–12.4  Convulsion 26 (14.1) 9.8–19.9  Black urine 2 (1.1) 0.3–3.9 aAll measurements in axillary bAppropriate for age Patients’ baseline variables and presenting complaints Tachycardia 83 (45.1%) was the most frequent abnormal vital sign among enrolled patients; hypoxia 8 (4.3%) was least. Fever 125 (67.9%), headache 56 (30.4%) and general body malaise 41 (22.3%) were the top three presenting complaints (Table 1). Investigations ordered at EMD Of the 184 patients tested for malaria 132 (32.5) tested positive [by either rapid diagnostic malaria test (MRDT), blood slide for malaria parasite or both]. Among patients who received complete blood cell counts order 25 (13.5%) had elevated white blood counts and 21 (11.4%) had severe anaemia (Hb < 7 g/dL) of who 5 (2.7%) received blood transfusion in EMD (Additional file 2: Table S1). Frequency and type of malaria complications Anaemia 21 (11.4%) was the most frequent complication, followed by renal failure 15 (8.2%) while disseminated intravascular coagulopathy (DIC) was the least frequent complication (Table 2). Table 2 Patient’s rate of complication Complications Overall (N = 184) 95% CI n/N (%) % Severe anaemia (Hb < 7 g/dL) 21(11.4) 7.6–16.8 Acute renal failurea 15 (8.2) 5.0–13.0 Respiratory distressb 8 (4.3) 2.2–8.3 Hypoglycemia (< 3 mmol/L) 6 (3.2) 1.5–6.9 Cerebral malaria 6 (3.2) 1.5–6.9 Shock 3 (1.6) 0.6–4.7 DIC 1 (0.5) 0.1–3.0 DIC disseminated intravascular coagulopathy aRIFLE criteria bSPO2 < 91% and difficulty in breathing complain Patients’ disposition and hospital outcomes Of the 184 malaria patients seen in the EMD, 99 (53.8%) were hospitalized for inpatient care and 3 patients (1.6%) died in the EMD. The overall in-hospital mortality rate was 3.8% (Table 3). The median length of stay in hospital was 1 day (IQR 1–2) days. Table 3 Patients’ EMD outcome Outcome N = 184 95% CI n (%) % Discharged from EMD 77 (41.8) 35.0–49.1 Admitted 99 (53.8) 49.6–60.9 Died in EMD 4 (2.2) 0.9–5.5 Overall hospital mortalitya 7 (3.8) 1.9–7.6 aIncluding EMD mortality Discussion The establishment of a full capacity EMD at MNH in Tanzania manage provided an opportunity of early stabilization of acutely ill and injured patients, including those with acute complication of malaria. In this study over half of patients who were clinically suspected to have malaria by providers had neither laboratory evidence of malaria no features of severe malaria, a similar finding from what has been observed from other studies [11]. While we did not pursue further on to the treatment of this group of patients, we believe that maintaining the final EMD diagnosis of malaria, in absence of laboratory evidence and features of severe malaria, potentially put these patients in possibility of receiving antimalarial, contrary to the current national guidelines for diagnosis and management of malaria [12]. The rate of positive testing among those who were clinically suspected and tested for malaria was relatively higher compared to what has observed in other similar studies in our settings [11, 13], and we believe this might be attributed to the fact that most of these patients presents to this hospital after visiting several health facilities at district and regional levels, and hence their acuity of illness of illness is higher compared to similar studies in our settings. Interestingly, we found that majority of patients in our study population were adults above the age of 18, and were self-referral from home with low compliance to utilization of insecticide treated net (ITN). The low compliance can be attributed to many factors as seen in previous studies [14], and this know to be associate with high malaria parasitaemia, and also frequent malaria in infection in most of malaria endemic regions [15]. Fever and headache accounted for over 90% of patients presenting complaint in those who tested positive for malaria. This is contrary to what has been seen in other studies that have shown viral infections to be the major cause of undifferentiated fever in naive outpatients [16]. We believe this might have been attributed to the differences in demographics of patients seen at this study (mostly adult) and the referral patterns of patients. Nearly half of patients in this study had features of complications of malaria. Hypokalaemia requiring replacement was observed found in 20% of patients however only 1% of patient in this study received hypokalemia management at EMD or in the wards. While we didn’t pursue the reasons for lack of treatment of hypokalemia, at the time of the study the department was quipped with management guidelines for hypokalemia, which calls for provision of supplemental potassium for these patients. Anaemia was the most frequent complication of malaria observed in this study population, with over 10% of patients presenting with severe anaemia. Despite this presentation only one quarter of these patients received blood as part of care. This finding further complement the observation made by Shari et al. in a prospective observation of anaemic children presenting to same EMD in which only 23% of children with indications received transfusion [17]. None of patients with acute renal failure seen in this group received dialysis; all patients were managed conservatively until discharge, despite this, over 80% of these patients survived to hospital discharge. Less than 10% of patients were found to have cerebral malaria, unlike what has been observed in other studies of complications of malaria [7, 18]. One-third of patients, who were eligible to receive antimalarial treatment, did not receive it while in the EMD and we could not verify whether these patients received antimalarial while in the wards. However, several factors might have contributed to this, including the fact that some of these patients might have already received initial treatment of malaria prior to referral to this EMD. Most patients were admitted to the wards for the inpatient care, nine patients with uncomplicated malaria were also admitted to the wards, indicating the potential for other illnesses and complications that might have been associated with current malaria diagnosis. The observed mortality rate in our study low compared to other studies of malaria done in similar settings, and this is despite the relatively short duration of hospital stay compared to other settings [19]. Conclusions There is a substantial burden of patients with complications of malaria presenting in the largest public ED in Tanzania. We have described their clinical presentation, management, outcomes and gaps in care provision. Future studies should focus on factors affecting delivery of appropriate care in patients with complications of malaria. Limitations This was a single-centre study and our results may not necessarily be generalizable to other settings, however the EMD at MNH is the largest tertiary referral hospital in Tanzania, and receives acutely ill and injured patients from all over the country. Abbreviations AKI:  acute kidney injury ED:  emergency department EMD:  Emergency Medicine Department ICU:  intensive care unit ITN:  insecticide treated net MNH:  Muhimbili National Hospital MRDT:  malaria rapid diagnostic test WHO:  World Health Organisation Declarations Acknowledgements The authors wish to give her gratitude to the research assistants, study participants, EMD MNH Attending Physicians for their assistance in this project, and everyone who prayed for my success. Funding This was a non-funded project; the principal investigators used their own funds to support the data collection and logistics. Authors’ contributions RY contributed to the conception and design of the study, acquired, analysed and interpreted the data, and drafted original manuscript and revised the manuscript. HRS contributed to conception and design of the study, data acquisition, entry, validation, and analysis and also critically revised the manuscript. PN contributed to the design of the study, data validation, and analysis and also revised the manuscript. JAM contributed to conception and design of the study, data validation, review, and analysis and also critically revised the manuscript. All authors read and approved the final manuscript. Ethics approval and consent to participate The institutional review board and the committee on research of the Muhimbili National Hospital (MNH) approved the study protocol. MNH administration provided permission for in-hospital follow-up. Written informed consent was obtained from patients, and patient parents or guardians when a patient was a child below the age of 18 years. Consent for publication Not applicable. Competing interests The authors declare that they have no competing interests. Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Additional files 13104_2019_4388_MOESM1_ESM.doc Additional file 1: Figure S1. Study flow diagram: patient enrollment results and outcomes. 13104_2019_4388_MOESM2_ESM.docx Additional file 2: Table S1. Investigations ordered in the emergency department. Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Authors’ Affiliations (1) Emergency Medicine Department, Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Dar es Salaam, Tanzania (2) Emergency Medicine Department, Muhimbili National Hospital, Dar es Salaam, Tanzania References Malaria & medicines. Medicines for malaria venture. http://www.mmv.org/malaria-medicines?gclid=CjwKEAjwiru9BRDwyKmR08L3iS0SJABN8T4vy3Y2UNNRRp9QmQ6GKtWJOAQH–Mhhgqbk0QfcnDE0RoC_Qvw_wcB. Accessed 13 Aug 2016.Summary of the world malaria report 2015. http://apps.who.int/iris/bitstream/10665/205224/1/WHO_HTM_GMP_2016.2_eng.pdf?ua=1. 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Raya Yusuph, Hendry R. Sawe, Paulina N. Nkondora, Juma A. Mfinanga. Profile and outcomes of patients with acute complications of malaria presenting to an urban emergency department of a tertiary hospital in Tanzania, BMC Research Notes, 2019, 345, DOI: 10.1186/s13104-019-4388-8