Re: Hair dye use, genetic variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2), and risk of non-Hodgkin lymphoma, author response

Carcinogenesis, May 2008

Shelia Hoar Zahm, Lindsay M. Morton, Leslie Bernstein, Sophia S. Wang, Joanne S. Colt, Richard K. Severson, Robert Welch, Patricia Hartge

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Re: Hair dye use, genetic variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2), and risk of non-Hodgkin lymphoma, author response

Shelia Hoar Zahm 3 Lindsay M.Morton 3 Leslie Bernstein 2 3 Sophia S.Wang 3 Joanne S.Colt 3 Richard K.Severson 1 3 Robert Welch 0 3 Patricia Hartge 3 To whom correspondence should be addressed. Tel: 2 3 Fax: 2 3 Email: zahms@mail.nih.gov 3 0 Core Genotyping Facility, Advanced Technology Center, National Cancer Institute, National Institutes of Health, Department of Health and Human Services , Gaithersburg, MD 20877 1 Department of Family Medicine and Karmanos Cancer Institute, Wayne State University , Detroit, MI , 48201 2 Beckman Research Institute, City of Hope Comprehensive Cancer Center , Duarte, CA 91010 3 Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services , Rockville, MD 20852 Dear Sir, We thank Drs Bailey and Skare for their letter and clarification regarding the term 'depth' of color for the concept we labeled 'intensity of tone' (1). It will improve future reports on hair coloring to use the industry terminology. We are also grateful for the opportunity to clarify the content and origins of personal communication data regarding color depth. On 29 April 2003, Dr William Dressler of Proctor and Gamble/Clairol presented a graph displaying concentrations of total permanent dyes and p-phenylenediamine (PPD) by color shade and depth at a meeting of the Clairol Epidemiology Peer Review Group organized by Johns Hopkins University under contract with Clairol. By the time of our publication (1), Dr Dressler had retired and, in response to our request, Dr Skare gave us permission to use the information and stated that she should be cited as the source. Controls Black or dark brown permanent hair dye use (excludes use of permanent, dark blonde dyes) No hair coloring product use First use before 1980 First use in 1980 or after Frequency of use before 1980 (applications/year) 14 57 8 Duration of use before 1980 (years) 14 514 15 Cumulative applications before 1980 124 2599 100 NAT2 phenotype Slow No hair coloring product use First use before 1980 Rapid/intermediate No hair coloring product use First use before 1980 NAT1 genotype NAT1 any No hair coloring product use First use before 1980 NAT1 10/any NAT1 10/ 10 No hair coloring product use First use before 1980 NHL subtype Follicular lymphoma No hair coloring product use First use before 1980 DLBCL No hair coloring product use First use before 1980 OR (95% CI)b 1.0 (referent) 1.6 (0.9, 2.7) 0.6 (0.4, 1.1) 2.2 (0.9, 5.3) 2.1 (0.9, 4.9) 1.0 (0.5, 2.1) 1.5 (0.8, 2.9) 1.0 (0.4, 2.4) 3.9 (1.2, 12.5) 1.6 (0.8, 3.2) 1.7 (0.7, 4.2) 1.4 (0.6, 3.4) 1.0 (referent) 1.5 (0.6, 3.6) 1.0 (referent) 3.3 (1.3, 8.6) 1.0 (referent) 1.5 (0.7, 3.3) 1.0 (referent) 2.5 (0.9, 7.6) 1.0 (referent) 2.0 (0.9, 4.4) 1.0 (referent) 1.1 (0.5, 2.4) OR (95% CI)b 1.0 (referent) 1.5 (0.9, 2.6) 0.7 (0.3, 1.5) 1.8 (0.8, 4.4) 2.3 (0.9, 5.7) 0.9 (0.4, 2.0) 1.5 (0.7, 3.0) 0.7 (0.3, 1.9) 4.6 (1.2, 17.0) 1.6 (0.8, 3.4) 1.3 (0.5, 3.4) 1.5 (0.6, 3.8) 1.0 (referent) 1.8 (0.7, 4.5) 1.0 (referent) 2.6 (1.0, 7.0) 1.0 (referent) 1.3 (0.6, 3.1) 1.0 (referent) 2.5 (0.8, 8.1) 1.0 (referent) 2.1 (0.9, 4.7) 1.0 (referent) 0.8 (0.4, 1.9) Acknowledgements Conflict of Interest Statement: None declared.


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Shelia Hoar Zahm, Lindsay M. Morton, Leslie Bernstein, Sophia S. Wang, Joanne S. Colt, Richard K. Severson, Robert Welch, Patricia Hartge. Re: Hair dye use, genetic variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2), and risk of non-Hodgkin lymphoma, author response, Carcinogenesis, 2008, 1084-1085, DOI: 10.1093/carcin/bgn023