Delayed onset porous polyethylene implant-related inflammation after orbital blowout fracture repair: four case reports

BMC Ophthalmology, Jul 2016

Background Porous polyethylene implants are commonly used in orbital blowout fracture repair because of purported biocompatibility, durability, and low frequency of complications. Delayed inflammation related to porous polyethylene sheet implants is very rare and no case series of this condition have been reported. Case Presentation This is a retrospective review of clinical presentations, radiographic findings, histopathological findings, treatments, and outcomes of patients who developed delayed complications in orbital blowout fracture repair using porous polyethylene sheets. Four male patients were included with a mean age of 49 years (range 35–69 years). Blowout fracture repair was complicated with implant-related inflammation 10 months, 2 years, 3 years, and 8 years after surgery. Chronic and subacute orbital inflammatory signs were noted in two patients and acute fulminant orbital inflammation was found in two patients. Three patients developed peri-implant abscesses and one patient had a soft tissue mass around the implant. All patients underwent implant removal and two of these patients with paranasal sinusitis had sinus surgery. Histopathological findings revealed chronic inflammatory changes with fibrosis, and one patient had foreign body granuloma with culture positive Staphylococcus aureus. Conclusions Delayed complications with porous polyethylene sheets used in orbital blowout fracture repair may occur many years following the initial surgery in immunocompetent patients. Low-grade or fulminant inflammation could complicate blowout fracture repair related with the implant.

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Delayed onset porous polyethylene implant-related inflammation after orbital blowout fracture repair: four case reports

Aryasit et al. BMC Ophthalmology Delayed onset porous polyethylene implant-related inflammation after orbital blowout fracture repair: four case reports Orapan Aryasit 3 Danny S. Ng 2 Alice S. C. Goh 1 Kyung In Woo 0 Yoon-Duck Kim 0 0 Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul , South Korea 1 International Specialist Eye Center (ISEC) , Kuala Lumpur , Malaysia 2 Department of Ophthalmology and Visual Sciences, Faculty of Medicine, The Chinese University of Hong Kong , Kowloon , Hong Kong 3 Department of Ophthalmology, Faculty of Medicine, Prince of Songkla University , Hat Yai, Songkhla , Thailand Background: Porous polyethylene implants are commonly used in orbital blowout fracture repair because of purported biocompatibility, durability, and low frequency of complications. Delayed inflammation related to porous polyethylene sheet implants is very rare and no case series of this condition have been reported. Case Presentation: This is a retrospective review of clinical presentations, radiographic findings, histopathological findings, treatments, and outcomes of patients who developed delayed complications in orbital blowout fracture repair using porous polyethylene sheets. Four male patients were included with a mean age of 49 years (range 35-69 years). Blowout fracture repair was complicated with implant-related inflammation 10 months, 2 years, 3 years, and 8 years after surgery. Chronic and subacute orbital inflammatory signs were noted in two patients and acute fulminant orbital inflammation was found in two patients. Three patients developed peri-implant abscesses and one patient had a soft tissue mass around the implant. All patients underwent implant removal and two of these patients with paranasal sinusitis had sinus surgery. Histopathological findings revealed chronic inflammatory changes with fibrosis, and one patient had foreign body granuloma with culture positive Staphylococcus aureus. Conclusions: Delayed complications with porous polyethylene sheets used in orbital blowout fracture repair may occur many years following the initial surgery in immunocompetent patients. Low-grade or fulminant inflammation could complicate blowout fracture repair related with the implant. Delayed inflammation; Orbital fracture; Porous polyethylene Background Delayed complications related to alloplastic implant materials in orbital blowout fracture repairs are infrequent and generally appear as isolated case reports. Warrier et al. reported inflammation and infection that developed 1.5–20 years after silicone implants for orbital fracture repair [ 1 ]. Custer et al. described six cases of late infection/inflammation in supramid implants ranging from 8 to 16 years after implantation [ 2 ]. Longterm durability and safety of porous polyethylene implants for orbital fracture reconstruction have been reported [ 3, 4 ]; however, there have been very few reported late complications. In a retrospective review of 30 patients, Ng et al. reported a patient who developed delayed onset recurrent implant infection leading to implant removal [5]. Samimi et al. reviewed 21 explanted periorbital biomaterials due to nonresolving infection or exposure and reported one immunosuppressed patient who had granulomatosis with polyangiitis with an infected porous polyethylene sheet after 3 years [ 6 ]. The former case developed several bouts of inflammation from 6 months after fracture surgery, and finally had the implant removed 36 months after the original surgery [ 5 ]. In addition, the latter case involved an immunocompromised patient [ 6 ]. In this case series, we describe the clinicopathological features of inflammation after orbital blowout fracture repair using porous polyethylene sheets, which is rarely encountered after a long postoperative duration in immunocompetent patients [ 7 ]. Case presentation Medical records of four consecutive patients who developed delayed complications related with porous polyethylene sheets after orbital blowout fracture repair at Samsung Medical Center between 2007 and 2010 were retrospectively reviewed. Delayed onset inflammation was regarded if an implant-related inflammation occurred 6 months later than the fracture repair. The clinical presentations, radiographic findings, histopathological findings, and treatment and outcome data were collected. The Samsung Medical Center Institutional Review Board approved the retrospective review of the patients’ data, and the study adhered to the tenets of the Declaration of Helsinki. All patients were male with mean age of 49 years (range 35–69 years) (Table 1). None had a significant past medical history or current disease. Orbital blowout fracture occurred after automobile traffic accidents (two patients), sports injury (one patient), and an accidental fall (one patient). All patients had uneventful blowout fracture repair using porous polyethylene sheets (Medpor®, Porex Surgical, Newnan, GA, USA) of 1 mm thickness for correction of enophthalmos and diplopia, using a transconjunctival approach for the inferior wall and a transcaruncular approach for the medial wall fracture. All implants were soaked in gentamicin solution before implantation. Methylprednisolone (250 mg) was infused intravenously at the end of the surgery, and postoperative systemic antibiotics were administered. None of the patients showed sinusitis at the time of blowout fracture repair. The onset of symptoms varied among the patients. Patients 1 and 2 presented with subacute and chronic eyelid swelling and pain, respectively (Figs. 1a, 2a). Acute fulminant orbital inflammation was seen in patients 3 and 4, who had eye pain, conjunctival injection, and eyelid swelling with concurrent sinusitis. Patient 4 had an upper respiratory infection 2 weeks prior to the presentation of orbital inflammation. None of them had any anterior and posterior segment abnormalities or optic nerve dysfunction. The implants for the patients were well placed in the computed tomography (CT) scan except for one patient. The implant in the patient 3 was misplaced in the posterior orbit showing a gap between bony edge and the implant. All four patients underwent surgical exploration and implant removal under coverage of systemic antibiotics. The fibrotic tissue around the implant was resected partially and left behind for avoidance of vital orbital tissue damage. All the explanted implants were submitted for Gram staining and microbial culture. Histopathological findings of the orbital mass revealed fibrosis and chronic inflammation (Fig. 1). Patient 2 aYrs years, bF/U follow-up, cmos months, dCoNS coagulase negative Staphylococcus aureus, eCT computed tomography, fMR magnetic resonance imaging, gENT ear, nose and throat showed foreign body granuloma with giant cell infiltration adjacent to the fragmented implant spicules (Fig. 2). Coagulase negative Staphylococcus aureus was cultured from the explant. All patients had clinical resolution after explantation and systemic broad spectrum antibiotic treatment (Figs. 1b, 2b). Discussion Delayed inflammation related to orbital implantation for orbital fracture repair is very rare. Approximately 350 cases underwent orbital fracture repair using porous polyethylene sheets during the same period from 2007 to 2010 at Samsung Medical Center. Furthermore, there were no other cases out of 1000 patients throughout the entire surgical log of orbital fracture repair at the same institution since 1994. This complication is very rare but should be reported for clinicians who care for orbital fracture patients. A lack or reduction of fibrovascularization into the implant for orbital fracture repair might play a role in implant infection. Porous polyethylene is susceptible to infection in the early postoperative period before sufficient fibrovascular ingrowth occurs in 3 months [ 3, 8–11 ]. Our patient series showed delayed onset of porous polyethylene sheet-related infection or inflammation after 10 months and up to 8 years, which lagged beyond the duration for fibrovascularization. Mauriello et al. studied 10 patients who developed infections after alloplastic implants with silicone and gelatin film for orbital floor fracture repair, and noted that the predisposing factors were dental surgery, upper respiratory infection, implant extrusion into the maxillary sinus, medial implant migration resulting in dacryocystitis, rhinoplasty, and snorting cocaine [ 12 ]. Custer et al. reported small fistulous tracts between the supramid implant capsule and the maxillary sinus that led to infection [ 2 ]. In our case series, we speculate that the implanted porous polyethylene sheet and integrated surrounding fibrous tissue adjacent to the paranasal sinuses could still be an incompetent barrier to sinus infection, even after a long postoperative period. In patient 3, the edge of the implant did not cover the whole defect of the medial wall fracture, and which might serve as a precipitating cause of infection (Fig. 3). Patient 2 showed chronic inflammatory signs with abscess formation without sinusitis. The explanted porous polyethylene sheet was brittle and histopathological examination showed foreign body granuloma adjacent to the implant spicules. Microbial infection and long-term tissue inflammation could result in implant degradation. In an experimental study to examine the responses of implanted porous polyethylene after direct inoculation of Staphylococcus aureus into rats, electron microscopy showed bacteria and active inflammatory infiltrates on the degraded implant surface [ 11 ]. In another animal study, giant cells were detected at the interface between the implants and surrounding granulation tissue, indicating a chronic foreign body reaction [ 13 ]. In specific circumstances, porous polyethylene in the fracture site can precipitate chronic inflammation and foreign body reactions. Three of the patients in this series were culture negative for microorganisms. We could not determine whether the reasons involved prior use of antibiotics or sterile inflammation. Absorbable alloplastic materials are manufactured and used for orbital wall fracture. They were originally designed to sustain the prolapsed orbital tissue as long as the implant support was needed, and not to serve as a foreign body in the fracture site [ 14–20 ]. Long-term followup and accumulation of clinical experiences can help identify the proper implant for orbital wall fracture repair. Conclusions Porous polyethylene implants are commonly used in orbital blowout fracture repair because of purported biocompatibility, durability, and low frequency of complications. However, delayed onset of porous polyethylene implant infection or inflammation may complicate orbital fracture repair. Porous polyethylene sheets may provide an incompetent barrier to sinus infection, and can remain as a foreign body in the fracture site, resulting in an implant-related inflammation. Abbreviations CT, computed tomography; ENT, ear, nose and throat; MR, magnetic resonance Acknowledgements None. Availability of data and materials All the data supporting the findings is contained within the manuscript. Authors’ contributions OA analyzed and interpreted the clinical data and wrote the manuscript. DN also assisted in writing and revising the original manuscript and its English revision. AG made substantial contributions to the experimental design and acquisition of clinical data. KIW and KYD conceived the study, participated in its design and coordination, and revised the manuscript. All authors read and approved the final manuscript. Competing interests The authors declare that they have no competing interests. Consent for publication Written informed consent was obtained from the patients for publication of this case report and any accompanying images. 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Orapan Aryasit, Danny Ng, Alice Goh, Kyung Woo, Yoon-Duck Kim. Delayed onset porous polyethylene implant-related inflammation after orbital blowout fracture repair: four case reports, BMC Ophthalmology, 2016, 94, DOI: 10.1186/s12886-016-0287-0