Spectrum of acute flaccid paralysis in children

Pakistan Journal of Neurological Sciences (PJNS), Nov 2017

Acute flaccid paralysis (AFP) is a clinical syndrome characterized by rapid onset of weakness in a child aged less than 15 years due to any cause when polio is suspected(1). Exact cause of AFP with its incidence is needed for proper management.

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Spectrum of acute flaccid paralysis in children

V O L . Spectrum of acute flaccid paralysis in children Th e Children's Hospital 0 1 2 Th e Institute of Child Health 0 1 2 Lahore 0 1 2 Pakistan 0 1 2 0 1 2 M. Zia ur Rehman 0 1 2 0 Th e Children's Hospital & Th e Institute of Child Health , Lahore , Pakistan 1 Th e Children's Hospital & Th e Institute of Child Health , Lahore , Pakistan 2 Dr. Shaila Ali, Dr. M. Zia ur Rehman, Dr. Tipu Sultan Department of Pediatric Neurology The Children's Hospital & The Institute of Child Health , Lahore , Pakistan - SPECTRUM OF ACUTE FLACCID PARALYSIS IN CHILDREN Correspondence:Dr. Shaila Ali House # 15, Al-Razzaq Villas, Madhali Road, Sahiwal, Pakistan Email: Date of submission: June12, 2016 Date of revision: September 09, 2016 Date of acceptance: October, 2016 INTRODUCTION Acute flaccid paralysis (AFP) is a clinical syndrome characterized by rapid onset of weakness in a child aged less than 15 years due to any cause when polio is suspected(1). Exact cause of AFP with its incidence is needed for proper management. The South East Asian Region (SEAR) contains the largest remaining reservoir of wild polio virus in the world (2) The 3 endemic countries are Afghanistan ,Pakistan and Nigeria.(3) West Africa and other countries like Somalia, Syria, Kenya, Euthipia, Cameroon, Niger and Chad also have various reports of polio (4) .AFP surveillance continues to be a critical component of the World Health Organization (WHO) global polio eradication campaign(5). WHO estimates a background annual incidence of at least 1 case of AFP per 100,000 populations less than 15 years old, in the absence of wild poliovirus transmission. (6,7) Other causes of AFP include Guillain Barre Syndrome (GBS), transverse myelitis, traumatic neuritis, spinal cord compromise (low back trauma, abscesses or tumors), meningitis, encephalitis CVA, myopathies , neuropathies and hypokalemic periodic paralysis ( 8 ). GBS still remains the leading cause of AFP in developed as well as developing countries ( 9 ). The objectives of this review are to describe the incidence and differential diagnosis of potential causes of AFP, including distribution by age and gender. OBJECTIVE STUDY DESIGN To determine the spectrum of AFP cases in children. Retrospective, observational study. Place and duration of study: Department of Neurology, Children Hospital & the Institute of Child Health, Lahore form January 2013 to October 2013. METHODS Retrospectively, we extracted the data from multi centers of notified AFP cases. Causes of AFP were sorted out with their frequencies.All the patients with lower limb weakness were admitted for workup.Although the initial diagnosis was based upon clinical presentation, few laboratory investigations were carried out on the basis of the clinical picture. Two stool specimens collected ≥24 hours apart, both within 14 days of paralysis onset, and shipped on ice or frozen packs to a World Health Organization–accredited laboratory, arriving in good condition, as per guidelines given under National Polio surveillance project ( 10 ). All the stool samples were sent to virology laboratory at National Institute of Health Islamabad for isolation of polio virus. Serum electrolytes, Cerebrospinal fluid examination, Magnetic resonance imaging (MRI) of brain or spine and electrophysiological studies were carried out in certain cases when it was required or diagnosis was doubtful. The final diagnosis was based on the available clinical data, vaccination history and epidemiologic data of the province and laboratory results. RESULTS Out of 376 cases of AFP, there was male predominance 59.57% (n=224) with male to female ratio 1.5:1(age ranged 11-18 years) demonstrated in figure 1 and 2 .Highest no. of patients fell in other categories (23.9%) including neuropathy, myopathy, spinal muscular atrophy, sepsis and tuberculosis spine, followed by GBS (18.88%) traumatic neuritis (12.76%), hypokalemic hypotonia (9.30%), CNS infection (3.45%) and transverse myelitis (1.68%). Illnesses which present with lesser frequency includes spinal muscular atrophy, cerebral palsy, cellulitis (0.53%) and rickets (0.26%)(Table 1). Wild polio cases declined because of intensive oral polio vaccine immunization and were found to be 1.59% (n=6) in 6 districts of Punjab having 4 cases in west and each in north and south region.(Table 2) P A K I S T A N J O U R N A L O F N E U R O L O G I C A L S C I E N C E S DISCUSSION: Active surveillance of AFP in children less than 15 years old plays a pivotal role in monitoring suspected cases of paralytic poliomyelitis and provides evidence for the elimination of indigenous wild poliovirus. In 2012, the annual national Non-polio AFP rate in Pakistan (per 100,000 population aged <15 years) was 6.3 (range among the six provinces/territories: 2.4–9.1) which is high ( 10 ).In the present study, 6 cases of wild polio virus or vaccine associated polio virus were isolated. GBS is one of the important causes of AFP. This has been highlighted by the previous studies where incidence of GBS leading to AFP has ranged from 47.3-72.2% ( 8,11,12 ). T S Saraswathy et al conducted a study in Malaysia. where GBS was 32.2 % ( 13 ). A study carried out by Jasem et al in Iraqi children identified GBS as a common cause accounting to be 52 %. ( 14 ). In another study, conducted in Sindh by Memon I A et al ( 15 ), the most common cause of non-polio AFP identified in the series was GBS (21%). In our study, GBS was found to be (18.88%), the most common cause of non-polio virus AFP excluding the causes of pseudoparalysis (Table 3). transverse myelitis as compared to our study where (1.68%) of children had transverse myelitis . In some studies ,GBS was followed by viral myositis while in others by hypokalemic paralysis. ( 9,17 ). In our study, traumatic neuritis was the most common cause of non-polio AFP after GBS (Table 3) . The likely explanation for the difference in pattern may be due to more prevalent viral infections, decreased immunity in our malnourished children, incomplete vaccination, intramuscular injections and tuberculosis. There is male predominance as seen in other studies conducted in South East Asian region.( 9,14 ).(Figure 1).Age group varies in different areas of the region having preschool children affected in Sindh, Pakistan ( 15 ) while school children in our study and also in a study from Amritsar, India ( 9 ).(Figure 2) CONCLUSION Non polio cases of AFP are more than Polio. The study confirms GBS as the most common cause of AFP in the <15 years population of Punjab. The reporting of cases having pseudoparalysis is quite high. For global eradication of poliovirus (PV), Pakistan should remain vigilant for effective surveillance of Polio and non-polio cases 1 0 Conflict of interest: Author declares no conflict of interest. Funding disclosure: Nil 1 1 Acute flaccid paralysis surveillance: looking beyond the global poliomyelitis eradication initiative . EPI-INSIGHT . 2005 Jan: 6 ( 1 ) Sutter RW , Cochi SL . Poliomyelitis. In: Wallace RB, editor. Maxcy-Rosenau-Last: Public Health and Preventive Medicine. 14th ed. Stamford: Appleton and Lange , 1998 ; 123 -125 CDC Global Health , Update on CDC Polio eradication Effort , 2013 Polio eradication initiative, Case breakdown by country . Oct 2013 . Ahmad A , Rehman A . One year surveillance data of acute flaccid paralysis at Bahawalpur Victoria Hospital Bahawalpur . Pak J Med Sci . 2007 ; 23 : 308 - 312 Alcala H , The differential diagnosis of poliomyelitis and other acute flaccid paralysis . Bio Med Infant Mex . 1993 : 50 ; 136 - 144 Neuroepidemiology 2009 ; 32 : 150 - 163 . 8. Tsang RS , Valdivieso-Garcia A . Pathogenesis of Guillian syndrome . Expert Rev Anti Infec Ther . 2003 ; 1 : 597 - 608 9. Narang G S , Pahwa J S. Retrospective Study of Acute Flaccid Paralysis Cases from a Tertiary Care Centre in Amritsar . Pediatric Oncall. [serial online] 2011 [cited 2011 February 1 ];8. Art # 14 . 10. Progress Toward Poliomyelitis Eradication - Pakistan , January 2012 -September 201 Weekly, November 22 , 2013 / 62 (46); 934 - 938 ( stool sample) 11. Rehaman A , Idris M , Elahi M , Arif A . Guillian Barre Syndrome, the leading cause of Acute flaccid paralysis in Hazara division . J Ayub Coll Abbottabad 2007 ; 19 : 26 - 28 12. Molinero MR , Varon D , Holden KR , Sladev JT , Molina IB , Cleaves F . Epidemiology of childhood Guillain-barre syndrome as a cause of acute flaccid paralysis in Honduras 1989-1999 . J Child Neurol . 2003 ; 18 : 741 - 747 13 T S Saraswathy , H Nor Zahrin , M Y Apandi , D Kurup , J Rohani , S Zainah , N S Khairullah Virology Unit , Infectious Disease Research Center, Institute for Medical Research, Kuala Lumpur, Malaysia. The Southeast Asian journal of tropical medicine and public health (Impact Factor: 0.61) . 12/ 2008 ; 39 ( 6 ): 1033 - 9 . Source: PubMed 14 Jasem J , Marof K , Nawar A , Khalaf Y , Aswad S , Hamdani F , Islam M , Kalil A . Guillain-Barre Syndrome as a cause of acute flaccid paralysis in Iraqi children: a result of 15 years of nation-wide study . (BMC neurol) 2013 Dec 10 ; 13 ( 1 ): 195 . 15 Memon I A , Jamal A , Arif F , Murtaza G . Causes of non-polio AFP in children residing in the province of Sindh. Medical Channel Pediatrics . July -Sept 2010 : 16 ( 3 ) 16. D'Souza RM , Kennett M , Antony J , Herceg A , Harvey B , Longbottom H , Elliot E. Surveillance of acute flaccid paralysis in Australia, 1995 - 97 . Australian Paediatric Surveillance Unit. J Paediatric Child Health . 1999 ; 35 : 536 - 5 17. Sharma K S , Singh R , Shah G S. Guillain Barre Syndrome: Major Cause of Acute Flaccid Paralysis in Children and Adolescents of Nepal . Journal of Nepal Paediatric Society , 2011 : 31 ( 2 )

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Shaila Ali, M. Zia ur Rehman, Tipu Sultan. Spectrum of acute flaccid paralysis in children, Pakistan Journal of Neurological Sciences (PJNS), 2017,