Effects of physical & nutritional interventions on chronic inflammation in prefrail/frail personsSandra Haider

European Journal of Public Health, Nov 2016

Haider, S, Luger, E, Kapan, A, Schindler, K, Lackinger, C, Grabovac, I, Dorner, TE

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Effects of physical & nutritional interventions on chronic inflammation in prefrail/frail personsSandra Haider

3.E. Oral presentations: Physical activity and lifestyle in later life - Effects of physical & nutritional interventions on chronic inflammation in prefrail/frail persons Sandra Haider S Haider1, E Luger1, A Kapan1, K Schindler2, C Lackinger3, I Grabovac1, TE Dorner1 1Institute of Social Medicine, Centre for Public Health, Medical University of Vienna, Vienna, Austria 2Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria 3Department for Health Promotion and Prevention, SPORTUNION Austria, Vienna, Austria Contact: Background Aging and especially frailty is associated with an increase in chronic inflammation markers. As high inflammatory markers are associated with a decrease in muscle mass, strength and performance and predict mortality, it is important to stop or prevent a further increase. The aim of the study was to assess the effects of home visits with physical training and nutritional support conducted by non-professionals on chronic inflammation markers. Methods In this randomized controlled trial, community-dwelling persons assessed as prefrail or frail, received home visits from volunteers twice a week. While the physical training and nutritional group (PTN, n = 38) performed six strength exercises and discussed nutrition-related aspects, the social support group (SoSu, n = 36) only received home visits. At baseline and after 12 weeks, leucocytes, TNF-a, IL6 and CRP were analyzed; physical performance was assessed with the Short Physical Performance Battery. Withingroup differences were analyzed with paired t-test, betweengroup differences with ANCOVA for repeated measure, adjusted for baseline values, sex, intake of anti-inflammatory drugs and rheumatism. To examine the association between changes in inflammation markers and changes in physical performance, linear regression analyses were performed. Results Mean age was 83 years (SD 8). Log-transformed IL-6 and CRP of the PTN group did not change significantly, whereas in the SoSu group log-IL-6 increased by 0.21 pg/ml (95%CI: 0.06, 0.36) and log-CRP by 0.32 mg/l (95%CI: 0.05, 0.59). In these parameters a significant difference between groups was determined. Leucocytes and TNF-a did no change neither in the PTN nor in the SoSu group. An increase in physical performance was associated with a decrease in log-CRP (?=? 0.237; p = 0.034). Conclusions Strength training with nutritional support provided by volunteers might effectively contribute to prevent further increase in chronic inflammation in prefrail and frail adults. Key messages: Physical training and nutritional support might influence chronic inflammation in frail and prefrail individuals An increase in physical performance is associated with a decrease in CRP


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Haider, S, Luger, E, Kapan, A, Schindler, K, Lackinger, C, Grabovac, I, Dorner, TE. Effects of physical & nutritional interventions on chronic inflammation in prefrail/frail personsSandra Haider, European Journal of Public Health, 2016, DOI: 10.1093/eurpub/ckw166.026