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Survey of subjective "God encounter experiences": Comparisons among naturally occurring experiences and those occasioned by the classic psychedelics psilocybin, LSD, ayahuasca, or DMT

Naturally occurring and psychedelic drug–occasioned experiences interpreted as personal encounters with God are well described but have not been systematically compared. In this study, five groups of individuals participated in an online survey with detailed questions characterizing the subjective phenomena, interpretation, and persisting changes attributed to their single most...

Caccioppoli-type estimates and Hardy-type inequalities derived from weighted p-harmonic problems

We obtain Caccioppoli-type estimates for nontrivial and nonnegative solutions to anticoercive partial differential inequalities of elliptic type involving weighted p-Laplacian: \(-\Delta _{p,a} u:= -{\mathrm {div}}(a(x)|{\nabla }u|^{p-2}{\nabla }u)\ge b(x)\Phi (u)\chi _{\{u>0\}}\), where u is defined in a domain \(\Omega \). Using Caccioppoli-type estimates, we obtain several...

Effects of vitamin D3 and its chemical analogs on the growth of Hodgkin’s lymphoma, in vitro

ObjectiveVitamin D receptor (VDR) activities have been noted for a number of B cell malignancies which showed varying sensitivities to vitamin D3 (1,25-dihydroxyvitamin D3, VD3, calcitriol) and its synthetic analogs. The objective of this study was to address the potential effects of VD3 and vitamin D3 analogs (VDAs) on the growth of Hodgkin’s lymphoma (HL), a malignant pathology...

How to include socio-economic considerations in decision-making on agricultural biotechnology? Two models from Kenya and South Africa

This article contributes to the debate about how regulatory science for agricultural technologies can be ‘opened up’ for a more diverse set of concerns and knowledges. The article focuses on the regulation of ‘socio-economic considerations’ for genetically modified organisms. While numerous countries have declared their intent to include these considerations in biotechnology...

Jejunoileal GIST: A Rare Case of Transient Intussusception and Gastrointestinal Bleeding

Gastrointestinal stromal tumors (GIST) comprised 0,2% of all GI tumors. They are typically asymptomatic, but can manifest with nonspecific GI symptoms, GI bleeding, or intussusception. The authors report a case of a 55-year-old female patient with hematochezia and a palpable mass on the left lower quadrant. Ultrasound revealed possible intussusception. However, CT scan did not...

Cognitive errors and anxiety in school aged children

Cognitive models of emotional disorders emphasize the role of biased information processing in the psychological functioning of anxious individuals. So far, the role of cognitive errors in problems of childhood anxiety disorders has received little empirical attention. This study analyzes the relations between cognitive errors and symptoms of anxiety in a sample of school aged...

Pediatricians

In Andalusia (Spain), pediatricians are the main formal counseling source about children's development and education. Unfortunately, there is a limited knowledge about their ideas, practices and skills to guide parents. In this study, through the content analysis of 26 pediatrician interviews, we describe their ideas and goals about anticipatory guidance. We also analyze their...

Questionnaire survey on cardiologists’ view and management of coronary microvascular disease in clinical practice

ObjectiveWe aimed to assess the opinion of Dutch cardiologists on coronary microvascular disease (CMD) and its management in clinical practice, and to assess the need for a CMD guideline among Dutch cardiologists.MethodsWe developed an online questionnaire including different aspects of CMD which was reviewed by an expert panel. The questionnaire was distributed by e‑mail among...

A life course approach to mortality in Mexico

Objective. Research on early life socioeconomic status (SES), education and mortality is less established in developing countries. This analysis aims to determine how SES and education are patterned across the life course and associated with adult mortality in Mexico. Materials and methods. Data comes from 2001-2012 Mexican Health & Aging Study (Mexican adults age 50+, n= 11 222...

Persistent female genital mutilation despite its illegality: Narratives from women and men in northern Ghana

Background Globally, an estimated two million women have undergone Female Genital Mutilation (FGM), and approximately four percent of women who have been circumcised live in Ghana. In the Bawku Municipality and Pusiga District, sixty one percent of women have undergone the procedure. This study therefore aimed at identifying the factors that sustain the practice of FGM despite...

The importance of clinician, patient and researcher collaborations in Alport syndrome

Alport syndrome is caused by mutations in the genes COL4A3, COL4A4 or COL4A5 and is characterised by progressive glomerular disease, sensorineural hearing loss and ocular defects. Occurring in less than 1:5000, Alport syndrome is a rare genetic disorder but still accounts for > 1% of the prevalent population receiving renal replacement therapy. There is also increasing awareness...

Sterne’s Sentimental Temptations: Sex, Sensibility, and the Uses of Camp

Laurence Sterne’s lack of commitment to the tenets of sentimentality in A Sentimental Journey—present in his ability to mock and praise the individual capacity to feel, and more precisely, in his satirical reading of the “cult of sensibility,” the new ideological imperative to have and to showcase deep, sentimental feelings—remains as one of the central challenges for readings of...

Improving follow up after predictive testing in Huntington’s disease: evaluating a genetic counselling narrative group session

Recently updated Huntington’s disease (HD) predictive testing guidelines emphasise clinicians’ responsibility to facilitate emotional support following testing, regardless of the result. Yet models of post-test counselling support are poorly defined. Moreover, it is unclear how these might be best delivered. In this project, a genetic counsellor and clinical psychologist...

Hohe Statin-Adhärenz wird belohnt

Patienten mit kardiovaskulären Erkrankungen, die ihre Statintherapie strikt einhalten, haben laut einer großen Kohortenstudie aus den USA ein niedrigeres Sterberisiko als Patienten mit geringerer Therapieadhärenz.

Singular Points of the Wigner Caustic and Affine Equidistants of Planar Curves

In this paper we study singular points of the Wigner caustic and affine \(\lambda \)-equidistants of planar curves based on shapes of these curves. We generalize the Blaschke–Süss theorem on the existence of antipodal pairs of a convex curve.

Prevalence of p53 dysregulations in feline oral squamous cell carcinoma and non-neoplastic oral mucosa

Squamous cell carcinoma is the most common malignant oral tumor in cats. The late presentation is one of the factors contributing to the detrimental prognosis of this disease. The immunohistochemical expression of the p53 tumor suppressor protein has been reported in 24% to 65% of feline oral squamous cell carcinomas, but no study has systematically evaluated in this tumor the...

Skilful seasonal prediction of winter wind speeds in China

We demonstrate robust skill in forecasting winter (DJF) mean 10 m wind speeds for the period 1992/3–2011/12 over south-eastern China and the South China Sea (SE China) and northern-central (NC) China, with correlations exceeding 0.8 and 0.6 respectively. High skill over these regions is seen in two independent initialised ensembles which cover different time periods. The NC China...