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Histories of the Unprecedented: Climate Change, Environmental Transformations, and Displacement in the United States

While the speed of current climatic changes is unprecedented, their ramifications are not. Floods and droughts, sea-level rise, advancing glaciers, and desertification do have a history, and the same is true for the social causes and aftermaths of such extreme natural events. Therefore, history provides a fertile field for the analysis of how societies have dealt with severe...

Nocturnal enuresis in children is associated with differences in autonomic control

To assess the relationship between urine osmolality, cardiovascular parameters, and nocturnal enuresis in a population of children undergoing polysomnographic assessment.

Prevalence and distribution of Human Papillomavirus (HPV) genotypes among HIV infected women in Lomé, Togo

Human papillomavirus (HPV) infection is the most common sexually transmitted disease worldwide, and it particularly affects people living with human immunodeficiency virus (HIV). This study aimed to estimate the prevalence of HPV and to describe HPV genotypes in HIV-1 infected women in Lomé, Togo. From September 2014 to September 2015, a cross-sectional study was conducted in two...

Regulation of ATR activity via the RNA polymerase II associated factors CDC73 and PNUTS-PP1

Ataxia telangiectasia mutated and Rad3-related (ATR) kinase is a key factor activated by DNA damage and replication stress. An alternative pathway for ATR activation has been proposed to occur via stalled RNA polymerase II (RNAPII). However, how RNAPII might signal to activate ATR remains unknown. Here, we show that ATR signaling is increased after depletion of the RNAPII...

Employing Dietary Comparators to Perform Risk Assessments for Anti-Androgens Without Using Animal Data

This study investigated the use of androgen receptor (AR) reporter gene assay data in a non-animal exposure-led risk assessment in which in vitro anti-androgenic activity and exposure data were put into context using a naturally occurring comparator substance with a history of dietary consumption. First, several dietary components were screened to identify which selectively...

Herd Immunity Likely Protected the Men Who Have Sex With Men in the Recent Hepatitis A Outbreak in San Diego, California

A high seroprevalence of hepatitis A virus (81%) among human immunodeficiency virus–negative high-risk men who have sex with men is likely why this community was largely spared from a recent hepatitis A virus outbreak in San Diego, California.

Molecular analysis of holoprosencephaly in South America

Holoprosencephaly (HPE) is a spectrum of brain and facial malformations primarily reflecting genetic factors, such as chromosomal abnormalities and gene mutations. Here, we present a clinical and molecular analysis of 195 probands with HPE or microforms; approximately 72% of the patients were derived from the Latin American Collaborative Study of Congenital Malformations (ECLAMC...

A unique nanoparticulate TLR9 agonist enables a HA split vaccine to confer FcγR-mediated protection against heterologous lethal influenza virus infection

The development of a universal influenza vaccine that can provide a robust and long-lasting protection against a broader range of influenza virus strains is a global public health priority. One approach to improve vaccine efficacy is to use an adjuvant to boost immune responses to the target antigens; nevertheless, the role of adjuvants in the context of influenza vaccines is not...

Safety and efficacy of nivolumab in combination with S-1/capecitabine plus oxaliplatin in patients with previously untreated, unresectable, advanced, or recurrent gastric/gastroesophageal junction cancer: interim results of a randomized, phase II trial (ATTRACTION-4)

Nivolumab is approved as an option for third- or later-line treatment of advanced gastric/gastroesophageal junction (G/GEJ) cancer in several countries after ATTRACTION-2. To further improve the therapeutic efficacy of first-line therapy, exploration of a nivolumab-chemotherapy combination is warranted. In part 1 (phase II) of ATTRACTION-4, the safety and efficacy of nivolumab...

Synthesis of salt-stable fluorescent nanoparticles (quantum dots) by polyextremophile halophilic bacteria

Here we report the biological synthesis of CdS fluorescent nanoparticles (Quantum Dots, QDs) by polyextremophile halophilic bacteria isolated from Atacama Salt Flat (Chile), Uyuni Salt Flat (Bolivia) and the Dead Sea (Israel). In particular, a Halobacillus sp. DS2, a strain presenting high resistance to NaCl (3–22%), acidic pH (1–4) and cadmium (CdCl2 MIC: 1,375 mM) was used for...

Ocorrência de ureídeos em folhas de amendoim como indicativo de fixação simbiótica de nitrogênio atmosférico

Peanut plants developed in field experiments with nitrogen fertilizer and with inoculants were used as a source of material for this work. The results showed that plants fixing atmospheric nitrogen can be identified by determining the ureides content in the last fully developed leaf. This method is non destructive and permits a screening of a large number of rhizobia lines.

Integrated routine workflow using next-generation sequencing and a fully-automated platform for the detection of KRAS, NRAS and BRAF mutations in formalin-fixed paraffin embedded samples with poor DNA quality in patients with colorectal carcinoma

Background KRAS and NRAS mutations are identified resistance mutations to anti-epidermal growth factor receptor monoclonal antibodies in patients with metastatic colorectal cancer. BRAF status is also routinely assessed for its poor prognosis value. In our institute, next-generation sequencing (NGS) is routinely used for gene-panel mutations detection including KRAS, NRAS and...

Occorrence of Pseudomicrodochium suttonii in Brazil

Pseudomicrodochium suttonii was isolated from the soil of Derby Square, a leisure area in Recife city, Pernambuco, Brazil. For the isolation, suspensions were made in distilled sterile water. According to the literature, this is probably the first occurrence reported in South America.

Non-linear trends and low frequency oscillations in annual precipitation over Argentina and Chile, 1931-1999

Since the 1950's-1960's a large portion of Argentina has experienced a long period of high precipitation with important changes a 30-year period annual averages. Opposite conditions have taken place throughout the twentieth century in a large portion of Chile, with declining tendencies in annual precipitations. If such conditions prevail, the socio-economic implications of these...

Oregon Trails-Fact From Fiction

By Thomas W. Leonhardt, Published on 01/24/19

Reflexões acerca do papel do fonoaudiólogo junto à família de uma criança com Transtorno Global do Desenvolvimento: estudo de caso

The aim of this study was to reflect about and discuss the role of a speech-language pathologist with the family of a child with Pervasive Development Disorder. This case study reported the case of a child with Pervasive Development Disorder that attended speech-language therapy from July/2002 to November/2004. The excerpts of clinical material depict the course of the patient's...

Updating bounds on R-parity violating supersymmetry from meson oscillation data

Abstract We update the bounds on R-parity violating supersymmetry originating from meson oscillations in the B d/ s 0 and K0 systems. To this end, we explicitly calculate all corresponding contributions from R-parity violating operators at the one-loop level, thereby completing and correcting existing calculations. We apply our results to the derivation of bounds on R-parity...