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In vitro and ex vivo evaluation of the anti-Giardia duodenalis activity of the supernatant of Slab51 (SivoMixx)

The effects on Giardia duodenalis of Slab51 probiotic supernatants were evaluated in vitro and ex vivo. In vitro, Slab51 (101 UFC) was cultured and the obtained supernatant was filtered, adjusted at pH 7, and added (100μl/ml) as such (Slab51 FS) or after heat-treatment, to G. duodenalis cultures to evaluate its effects on G. duodenalis trophozoites growth and adherence. For...

Severe bacterial meningitis due to an enterothecal fistula in a 6-year-old child with Currarino syndrome: evaluation of surgical strategy with review of the literature

Meningitis is a rare but serious complication in patients with Currarino syndrome. We present a 6-year-old girl with a fulminant meningitis due to an enterothecal fistula involving the anterior sacral meningocele. Initial treatment consisted of broad-spectrum intravenous antibiotic therapy and laparoscopic construction of a deviating double-loop ileostomy. This was followed by an...

Dynamics of the Ghrelin/Growth Hormone Secretagogue Receptor System in the Human Heart Before and After Cardiac Transplantation

Currently, the early preclinical detection of left ventricular dysfunction is difficult because biomarkers are not specific for the cardiomyopathic process. The underlying molecular mechanisms leading to heart failure remain elusive, highlighting the need for identification of cardiac-specific markers. The growth hormone secretagogue receptor (GHSR) and its ligand ghrelin are...

Pure Laparoscopic Anatomical Segment V Resection Using the Extrafascial and Transfissural Glissonean Approach

BackgroundThe Glissonean approach is a widely used, effective technique for anatomical segmentectomy using an open or laparoscopic approach.1–4 In the extrafascial Glissonean approach, the deep tertiary branches of the right anterior portal pedicle may be difficult to dissect from the liver hilum.5,6 We present a pure laparoscopic anatomical segment V resection using the...

Viral labeling of neurons synaptically connected to nucleus accumbens somatostatin interneurons

The nucleus accumbens, a key brain reward region, receives synaptic inputs from a range of forebrain and brainstem regions. Many of these projections have been established using electrophysiology or fluorescent tract tracing. However, more recently developed viral tracing techniques have allowed for fluorescent labeling of synaptic afferents in a cell type-specific manner. Since...

The evolutionary contingency thesis and evolutionary idiosyncrasies

Much philosophical progress has been made in elucidating the idea of evolutionary contingency in a recent re-burgeoning of the debate. However, additional progress has been impaired on three fronts. The first relates to its characterisation: the under-specification of various contingency claims has made it difficult to conceptually pinpoint the scope to which ‘contingency...

Growth and reproductive characteristics of rarely observed resident female Dolly Varden (Salvelinus malma malma) in North America

Among North American populations of northern form Dolly Varden (Salvelinus malma malma) exhibiting partial migration, the resident female life history is rarely encountered. Between 2012 and 2016, three sexually mature females confirmed as residents using otolith strontium analysis were captured from three rivers in the western Canadian Arctic (< 1% of residents sampled). Size-at...

A case report of atrial fibrillation in a patient with heparin resistance associated with an antithrombin III deficiency successfully treated by radiofrequency catheter ablation using a direct thrombin inhibitor

Pulmonary vein antrum isolation has proven to be a useful strategy for radiofrequency catheter ablation (RFCA) of atrial fibrillation (AF) worldwide. Anticoagulation therapies are necessary to avoid thromboembolic events before, during, and after RFCA of AF. During the RFCA procedure for AF, it is recommended that the activated coagulation time be maintained between 300 s and 400...

Memories and prevalence of posttraumatic stress disorder in intensive care units

The present study evaluated the prevalence of PTSD indicators in patients who had to be hospitalized in ICU six months after being discharged and examined the relationship between PTSD and mnemonic memories. Participants were 41 adult patients with different diseases who answered questionnaires about PTSD, memory and clinical information. It was identified that 24.4% of the...

Genetic diversity of Chamaecrista fasciculata (Fabaceae) from the USDA germplasm collection

ObjectiveChamaecrista fasciculata is a widespread annual legume across Eastern North America, with potential as a restoration planting, biofuel crop, and genetic model for non-papillinoid legumes. As a non-Papilinoid, C. fasciculata, belongs to the Caesalpiniod group in which nodulation likely arose independently of the nodulation in Papilinoid and Mimosoid legumes. Thus, C...

The role of artificial intelligence and machine learning in harmonization of high-resolution post-mortem MRI (virtopsy) with respect to brain microstructure

Enhanced resolution of 7 T magnetic resonance imaging (MRI) scanners has considerably advanced our knowledge of structure and function in human and animal brains. Post-industrialized countries are particularly prone to an ever-increasing number of ageing individuals and ageing-associated neurodegenerative diseases. Neurodegenerative diseases are associated with volume loss in the...

The duration aftereffect does not reflect adaptation to perceived duration

Recent studies have provided evidence for a role of duration-tuned channels in the encoding of duration. Duration encoding in these channels is thought to reflect the time between responses to the onset and offset of an event. This notion is in apparent conflict with studies that demonstrate that the perceived duration of an event can vary independently from the time separating...

Fixed-bed column adsorption study: a comprehensive review

Present paper involved the review of fixed-bed column studies for removal of various contaminants from synthetic wastewater. Basic concept of adsorption, its types (i.e., chemisorption and physisorption) and its mechanism, adsorbents and adsorbates were included. Comparison of batch and column adsorption study is mentioned. Complete study of breakthrough curve for designing...

Social Vulnerability (Re-)Assessment in Context to Natural Hazards: Review of the Usefulness of the Spatial Indicator Approach and Investigations of Validation Demands

While social vulnerability assessments (SVA) use spatial indicators and indices that have become state of the art, they also receive substantial critique. This article analyzes, by means of a literature review of 63 articles, if and in which aspects such an indicator approach is regarded as useful by scientific studies. The findings indicate a need for more research on the...

Oraler Januskinase-Inhibitor bei Psoriasis

Obwohl Patienten mit Psoriasis über eine ganze Palette an Behandlungsmöglichkeiten verfügen, besteht der ständige Bedarf an neuen effektiven und zielgerichteten Therapeutika. Tofacitinib gehört zu einer wichtigen neuen Therapieklasse für Psoriasis, den Janus-Kinase-Inhibitoren. Der Vorteil: es wird oral verabreicht, was von vielen Patienten bevorzugt wird.

Detailed characterization of the solution kinetics and thermodynamics of biotin, biocytin and HABA binding to avidin and streptavidin

The high affinity (KD ~ 10−15 M) of biotin for avidin and streptavidin is the essential component in a multitude of bioassays with many experiments using biotin modifications to invoke coupling. Equilibration times suggested for these assays assume that the association rate constant (kon) is approximately diffusion limited (109 M-1s-1) but recent single molecule and surface...

A72 NUTRITIONAL INDICATORS AND POSTOPERATIVE OUTCOMES IN INFLAMMATORY BOWEL DISEASE: THE NSQIP SURGICAL COHORT

The inflammatory bowel diseases (IBD), which include Crohn’s disease (CD) and ulcerative colitis (UC), frequently lead to disease complications that require bowel surgery. Because of involvement of the intestines and increased catabolism due to inflammation, IBD patients, particularly those with ileal Crohn’s disease, are susceptible to protein energy malnutrition (PEM). These...