#### Emergence of antibiotic resistance in immunocompromised host populations: A case study of emerging antibiotic resistant tuberculosis in AIDS patients

Objective The evolution of antibiotic resistance is far outpacing the development of new antibiotics, causing global public health concern about infections that will increasingly be unresponsive to antimicrobials. This risk of emerging antibiotic resistance may be meaningfully altered in highly AIDS-immunocompromised populations. Such populations fundamentally alter the bacterial...

#### Search for steady point-like sources in the astrophysical muon neutrino flux with 8 years of IceCube data

The IceCube Collaboration has observed a high-energy astrophysical neutrino flux and recently found evidence for neutrino emission from the blazar TXS 0506$$+$$056. These results open a new window into the high-energy universe. However, the source or sources of most of the observed flux of astrophysical neutrinos remains uncertain. Here, a search for steady point-like neutrino...

#### Potential impacts of climate-related decline of seafood harvest on nutritional status of coastal First Nations in British Columbia, Canada

Background Traditional food systems are under pressure from various stressors, including climate change which is projected to negatively alter the abundance of marine species harvested by coastal First Nations (FNs) in British Columbia (BC). Objective To model the potential impacts of the climate-related declines in seafood production on the nutritional status of coastal BC FNs...

#### Characterization and genome annotation of a newly detected bacteriophage infecting multidrug-resistant Acinetobacter baumannii

A novel virulent bacteriophage, φAbp2, infecting multidrug-resistant (MDR) Acinetobacter baumannii was isolated from the wastewater of a sewage management centre at Southwest Hospital, China. Transmission electron microscopy and phylogenetic analysis revealed that φAbp2 belongs to the subfamily Peduovirinae. A one-step growth curve demonstrated that φAbp2 had a latent period of...

#### IGF and mTOR pathway expression and in vitro effects of linsitinib and mTOR inhibitors in adrenocortical cancer

PurposeThe IGF and mTOR-pathways are considered as potential targets for therapy in patients with adrenocortical carcinoma (ACC). This study aims to describe the IGF pathway in ACC and to explore the response to the combined treatment with the IGF1R/IR inhibitor linsitinib, and mTOR inhibitors (sirolimus and everolimus) in in vitro models of ACC.MethodsThe protein expression...

#### Higher Baseline Serum Irisin Decreases Risk for Body Mass Index Increment in Chinese Populations: A 3.2-Year Cohort Study

IntroductionIrisin, a newly discovered myokine, exerts beneficial effects on energy metabolism. However, published results from studies examining the relationship between irisin concentration and obesity have been conflicting. The aim of our study was to investigate the association between serum irisin level and obese individuals with different body mass index (BMI) values and to...

#### Fluid dynamics during bleb formation in migrating cells in vivo

Blebs are cellular protrusions observed in migrating cells and in cells undergoing spreading, cytokinesis, and apoptosis. Here we investigate the flow of cytoplasm during bleb formation and the concurrent changes in cell volume using zebrafish primordial germ cells (PGCs) as an in vivo model. We show that bleb inflation occurs concomitantly with cytoplasmic inflow into it and...

#### What Should a Spanish Graduate in Medicine in the European Higher Education System Know About Biochemistry and Molecular Biology? A Personal Reflection

For over 40 years of working in the area of biochemistry and molecular biology, 30 of which have been spent teaching at the University of Malaga, I have been involved in the theoretical and practical teaching of the subject initially called biochemistry and now called biochemistry and molecular biology (BMB). The expansion of this scientific discipline and the renewed interest in...

#### Chitosan-coated sour cherry kernel shell beads: an adsorbent for removal of Cr(VI) from acidic solutions

In this study, a composite biosorbent in the form of beads was produced from chitosan and the powder of sour cherry kernel shells. Characterization of chitosan-coated sour cherry kernel shell beads was done using elemental analysis, FT-IR spectroscopy, SEM, and EDX spectrum analysis. Adsorption capacity of chitosan-coated sour cherry kernel shell beads was tested in removal of Cr...

#### Algebraic surfaces, four-folds and moonshine

Abstract The aim of this note is to point out an interesting fact related to the elliptic genus of complex algebraic surfaces in the context of Mathieu moonshine. We also discuss the case of 4-folds.

#### Calculation Accuracy and Efficiency of a Transient Model for Submerged Entry Nozzle Clogging

A transient numerical model was proposed and validated by the current authors for nozzle clogging (Barati et al. in Powder Technol 329:181-98, 2018). The model can reproduce the experiment in pilot scale satisfactorily. In the present article, the main objective is to validate the model for application in industry process continuous casting of steel, referring to the model...

#### Twenty-five years of observations of soil organic carbon in Swiss croplands showing stability overall but with some divergent trends

The temporal evolution of soil organic carbon (SOC) is of major importance given its status as a key parameter in many soil functions. Furthermore, soils constitute an important reservoir of carbon in our environment. In light of climate change, consistent SOC data over extended periods in combination with information on agricultural management are much required, but still scarce...

#### Contested EU trade governance: transparency conundrums in TTIP negotiations

During TTIP negotiations, the European Commission was severely criticized by civil society organizations and public opinion for its secrecy regarding negotiation strategies and priorities. The Commission responded by making some negotiating texts publicly available. This article explores the implications of increasing transparency in trade negotiations. Drawing on negotiation...

#### Overcoming the Challenges of Water, Waste and Climate Change in Asian Cities

Unprecedented challenges in urban management of water, waste and climate change—amplified by urbanisation and economic growth—are growing in Asia. In this circumstance, cities need to be aware of threats and opportunities to improve their capacity in addressing these challenges. This paper identifies priorities, barriers and enablers of these capacities. Through the City...

#### Election Law and White Identity Politics

The role of race in American politics looms large in several election law doctrines. Regrettably, though, these doctrines’ analyses of race, racial identity, and the relationships between race and politics often lack sophistication, historical context, or foresight. The political status quo is treated as race-neutral, when in fact it is anything but. Specifically, the doctrines...

#### Aktiv rekonfigurierbares Robotersystem zum Aufbau geschlossener Strukturen in der Ebene

For auditory and visual perception, virtual reality systems offer a high-resolution simulation of reality at low cost. To bring digitized objects even closer to reality, programmable structures are presented in this work, which should enable not only visual but also tactile perception. The foundation of the programmable structure is a cellular robot whose cells can both deform...

#### Unraveling the genetic complexity underlying sorghum response to water availability

Understanding the adaptation mechanisms of sorghum to drought and the underlying genetic architecture may help to improve its production in a wide range of environments. By crossing a high yielding parent (HYP) and a drought tolerant parent (DTP), we obtained 140 recombinant inbred lines (RILs), which were genotyped with 120 DArT and SSR markers covering 14 linkage groups (LGs...

#### Externalizing and internalizing problems: contributions of attachment and parental practices

The relation between attachment and parental practices with externalizing (aggression and delinquency) and internalizing (social withdrawal and anxiety/depression) behavioral problems were investigated in this study. Participants were 289 children (from 9 to 12 years old) and 205 caregivers who answered distinct questionnaires: the formers on attachment and the later on parental...

#### Impact des Nuisances Sonores sur la Qualité de Vie des Travailleurs dans les Centrales Électriques de la Ville de Ouagadougou

Background: Hearing loss induced by noise is a common handicap in industrial environment. It constitutes an occupational disease that has a significant impact on the social and professional life of workers and their families. This paper focuses on analyzing the impact of noise in the power stations of the city of Ouagadougou. Participants and Methods: A prospective study was...

#### A community pharmacist medicines optimisation service for patients with advanced cancer pain: a proof of concept study

Background Patients with advanced cancer commonly experience pain and it is least controlled in community settings. Community pharmacists in the UK already offer medicines optimisation consultations although not for this patient group. Objective To determine whether medicines consultations for patients with advanced cancer pain are feasible and acceptable. Setting Community...