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Two-photon fluorescence and second harmonic generation characterization of extracellular matrix remodeling in post-injury murine temporomandibular joint osteoarthritis

End stage temporomandibular joint osteoarthritis (TMJ-OA) is characterized by fibrillations, fissures, clefts, and erosion of the mandibular condylar cartilage. The goal of this study was to define changes in pericellular and interterritorial delineations of the extracellular matrix (ECM) that occur preceding and concurrent with the development of this end stage degeneration in a...

Observational study of first-line chemotherapy including cetuximab in patients with metastatic colorectal cancer: CORAL trial

We aimed to clarify the clinical practice and outcomes of first-line cetuximab-containing chemotherapy in patients with metastatic colorectal cancer. Efficacy and safety were evaluated in each group classified by the European Society for Medical Oncology Guidelines 2012.

Effect of vitamin D supplementation on upper and lower limb muscle strength and muscle power in athletes: A meta-analysis

Background Vitamin D may play a role in skeletal muscle because of the discovery of VDR in skeletal muscle. However, vitamin D deficiency is a global problem, including athletes. Studies examining the effect of vitamin D supplementation on muscle function in athletes have inconsistent results. Therefore, we aimed to quantitatively summarize the evidence for the effect of vitamin...

Distortional buckling of composite thin-walled columns of a box-type cross section with diaphragms

Distortional buckling of axially compressed columns of box-like composite cross sections with and without internal diaphragms is investigated in the framework of one-dimensional theory. The channel members are composed of unidirectional fibre-reinforced laminate. Two approaches to the member orthotropic material are applied: homogenization based on the theory of mixture and...

IGF-1C domain-modified hydrogel enhances therapeutic potential of mesenchymal stem cells for hindlimb ischemia

BackgroundPoor cell engraftment and survival after transplantation limited the application of stem cell therapy. Synthetic biomaterials could provide an artificial microenvironment for stem cells, thereby improve cell survival and enhance the therapeutic efficiency of stem cells.MethodsWe synthesized a hydrogel by conjugating C domain peptide of insulin-like growth factor-1 (IGF...

Feeding by two closely related species of Chironomus (Diptera: Chironomidae) in south Baltic lagoons, with implications for competitive interactions and resource partitioning

Four major categories of food items were determined in the gut content of chironomid larvae collected in the Curonian and Vistula Lagoons in the spring–summer period of 2009–2011. These were detritus (range from 88 to 92% of the gut content, by volume), matter of plant (2–7%) and animal origin (0.2–0.5%), and mineral particles (3–7%). Plant matter comprised pine pollen, conidia...

A microfluidic photobioreactor for simultaneous observation and cultivation of single microalgal cells or cell aggregates

Microalgae are an ubiquitous and powerful driver of geochemical cycles which have formed Earth’s biosphere since early in the evolution. Lately, microalgal research has been strongly stimulated by economic potential expected in biofuels, wastewater treatment, and high-value products. Similar to bacteria and other microorganisms, most work so far has been performed on the level of...

Risk Identification and Quantitative Evaluation Method for Asset Integrity Management of Offshore Platform Equipment and Facilities

Asset Integrity Management (AIM) technology has been rapidly developed and applied so that it has become a main management technology of offshore platform equipment and facilities. Risk identification and quantitative evaluation method is one of the core contents in the AIM. However, most of the existing methods are qualitative analysis results, simple analysis process, and...

Effectiveness of Deep Learning Algorithms to Determine Laterality in Radiographs

Develop a highly accurate deep learning model to reliably classify radiographs by laterality. Digital Imaging and Communications in Medicine (DICOM) data for nine body parts was extracted retrospectively. Laterality was determined directly if encoded properly or inferred using other elements. Curation confirmed categorization and identified inaccurate labels due to human error...

Negotiated Rulemaking for U.S. Higher Education Regulatory Policy: A Process of Deliberative Democracy?

The rulemaking process through which higher education regulatory policy is created in the U.S. Department of Education has received critical attention in recent years. One concern is that this important policymaking process takes place in an agency of unelected officials, sometimes with the help of select interest groups. How, then, does this process maintain its democratic...

Compliance to the Integrated School Health Policy: Intersectoral and multisectoral collaboration

BACKGROUND: Implementation of the Integrated School Health Policy (ISHP) requires strong intersectoral collaboration on the part of key role players such as the Department of Health, Department of Basic Education and Department of Social Development. These departments and educational structures such as school governing bodies, teacher unions and learner organisations, academic...

Recursion relations in Witten diagrams and conformal partial waves

Abstract We revisit the problem of performing conformal block decomposition of exchange Witten diagrams in the crossed channel. Using properties of conformal blocks and Witten diagrams, we discover infinitely many linear relations among the crossed channel decomposition coefficients. These relations allow us to formulate a recursive algorithm that solves the decomposition...

Understanding Teacher Evaluation in Finland: A Professional Development Framework

This study explores the characteristics of the teacher evaluation model in Finland. Highlighting the unique qualities of the Finnish case, we also compare these teacher evaluation practices with the increasingly applied value-added model (VAM) for teacher evaluation across the globe. Our analysis revealed that the Finnish Model prioritises teacher empowerment and professional...

U(1) extension of the standard model from short-distance structure of spacetime

In this paper, we presented a \(\mathrm {U}(1)\) extension of the SM and the corresponding consequences, based on a more fundamental structure of the spacetime. We started fundamentally from a generally covariant theory which includes a set of the fields propagating dynamically in the fundamental spacetime and respecting for the SM gauge group. We then derived, in the effective...

Resolução Anafórica e Foco do Discurso: O Caso do Pronome Demonstrativo Francês "Híbrido

In the tradition of centering theory, many studies have shown a significant sensitivity of anaphoric pronouns to refer to focus entities in a discourse representation. This sensitivity would be absent with more explicit expressions like the repeated nouns. According to the principles of this theory, we present an experiment aiming at studying the function of the referential...

Perceived discrimination in medical settings and perceived quality of care: A population-based study in Chicago

Perceived discrimination in medical settings remains prevalent within the U.S. health care system. However, the details of these experiences and their associations with perceived quality of care are not well understood. Our study assessed multiple measures of perceived racial/ethnic discrimination in medical settings and investigated the locations and purported perpetrators of...

Differential responses of net N mineralization and nitrification to throughfall reduction in a Castanopsis hystrix plantation in southern China

BackgroundMany regions in the world are experiencing changes in precipitation pattern, which likely impact soil nitrogen cycling and availability. However, we know little about how soil nitrogen processes respond to drought stress under climate change.MethodsA continuous 5-year experiment of throughfall reduction treatment (TRT) was conducted in a Castanopsis hystrix plantation...

Cpf1 enables fast and efficient genome editing in Aspergilli

BackgroundCRISPR technology has revolutionized fungal genetic engineering by increasing the speed and complexity of the experiments that can be performed. Moreover, the efficiency of the system often allows genetic engineering to be introduced in non-model species. The efficiency of CRISPR gene editing is due to the formation of specific DNA double-strand breaks made by RNA...

Strategic experimentation with asymmetric players

We examine a two-player game with two-armed exponential bandits à la (Keller et al. in Econometrica 73:39–68, 2005), where players operate different technologies for exploring the risky option. We characterise the set of Markov perfect equilibria and show that there always exists an equilibrium in which the player with the inferior technology uses a cut-off strategy. All Markov...

A solitary fibrous tumor in the pelvic cavity of a patient with Doege-Potter syndrome: a case report

BackgroundA solitary fibrous tumor (SFT) is a mesenchymal lesion, which commonly develops in the thorax. Non-islet cell hypoglycemia is a rare paraneoplastic phenomenon caused by an extra-pancreatic tumor. We report a rare case of a pelvic SFT with severe hypoglycemia, which was considered to be Doege-Potter syndrome.Case presentationA 72-year-old man was referred to our hospital...

Electrolyte imbalances in an unselected population in an emergency department: A retrospective cohort study

Background Although electrolyte imbalances (EIs) are common in the emergency department (ED), few studies have examined the occurrence of such conditions in an unselected population. Objectives To investigate the frequency of EI among adult patients who present to the ED, with regards to type and severity, and the association with age and sex of the patient, hospital length of...

Development of RP-HPLC Method for the Estimation of Rabeprazole in Pure and Tablet Dosage Form

A simple, rapid, sensitive and precise High Performance Liquid Chromatographic (HPLC) method has been developed for the estimation of rabeprazole in bulk and tablet dosage form. In this method RP-C18 column (150 mm x 4.6 mm I.D, 5 µ m particle size) with mobile phase consisting of methanol and water in the ratio of 65:35 v/v in isocratic mode was used. The detection wavelength is...

Viroid species associated with the bark-cracking phenotype of 'Tahiti

Viroids have been used as "graft transmissible dwarfing agents" (GTDA) in several countries, mainly to reduce growth of citrus trees, thus increasing their density in orchards. In the State of São Paulo, Brazil, plants of the acid lime 'Tahiti' are usually grafted with a complex of GTDA, presumably viroids. The aim of the present work was the identification and molecular...

Evaluation of the Socio Emotional Learning (SEL) Activities on Self-Regulation Skills Among Primary School Children

I seek the experience of the primary school children who participated in the SEL Activities instructing self-regulation skill. I designed the SEL Activities and conducted them with the participant students’ classroom teacher. I used phenomenological methods (Moustakas, 1994) to collect data through semi-structured interviews with primary school children who are 10-years-old and...

Vimentin expression is retained in erythroid cells differentiated from human iPSC and ESC and indicates dysregulation in these cells early in differentiation

BackgroundPluripotent stem cells are attractive progenitor cells for the generation of erythroid cells in vitro as have expansive proliferative potential. However, although embryonic (ESC) and induced pluripotent (iPSC) stem cells can be induced to undergo erythroid differentiation, the majority of cells fail to enucleate and the molecular basis of this defect is unknown. One...