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Length of the ORF, position of the first AUG and the Kozak motif are important factors in potential dual-coding transcripts

A single mammalian transcript normally encodes one protein, but the transcript of GNAS (G-protein α-subunit) contains two reading frames and produces two structurally unrelated proteins, XLαs and ALEX. No other confirmed GNAS-like dual-coding transcripts have been reported to date, even though many such candidate genes have been predicted by bioinformatics analysis. In this study...

Plexin-B1 silencing inhibits ovarian cancer cell migration and invasion

Background Elevated Plexin-B1 expression has been found in diverse human cancers and in non-neoplastic tissues, and it mediates diverse biological and pathological activities. However, whether or not Plexin-B1 expression is involved in human ovarian tumors remains unclear. In the present study, Plexin-B1 expression was explored in benign and malignant human ovarian tumor tissues...

Fasting Plasma Glucose at 24–28 Weeks to Screen for Gestational Diabetes Mellitus: New evidence from China


The IL-10 and IFN-γ pathways are essential to the potent immunosuppressive activity of cultured CD8+ NKT-like cells

Background CD8+ NKT-like cells are naturally occurring but rare T cells that express both T cell and natural killer cell markers. These cells may play key roles in establishing tolerance to self-antigens; however, their mechanism of action and molecular profiles are poorly characterized due to their low frequencies. We developed an efficient in vitro protocol to produce CD8+ T...

Breast-Feeding and Risk for Childhood Obesity: Response to Plagemann et al.

explanations for differences in our findings were speculative; thus, we have no further comments in this regard. ELIZABETH J. MAYER-DAVIS, PHD1 SHERYL L. RIFAS-SHIMAN, MPH2 LI ZHOU, BS1 FRANK B. HU, MD

Breast-Feeding and Risk for Childhood Obesity: Does maternal diabetes or obesity status matter?

OBJECTIVE— We sought to evaluate whether maternal diabetes or weight status attenuates a previously reported beneficial effect of breast-feeding on childhood obesity. RESEARCH DESIGN AND METHODS— Growing Up Today Study (GUTS) participants were offspring of women who participated in the Nurses’ Health Study II. In the present study, 15,253 girls and boys (aged 9–14 years in 1996...

Inhibition of the activating signals in NK92 cells by recombinant GST-sHLA-G1α chain

YAO & Rou Li ZHOU AuthorsSearch for Ai Yu YAO in:Nature Research journals • PubMed • Google ScholarSearch for Hai Yang TANG in:Nature Research journals • PubMed • Google ScholarSearch for Yun WANG ... in:Nature Research journals • PubMed • Google ScholarSearch for Mei Fu FENG in:Nature Research journals • PubMed • Google ScholarSearch for Rou Li ZHOU in:Nature Research journals • PubMed • Google Scholar

Genome-wide association analysis identifies three new risk loci for gout arthritis in Han Chinese

Immunology Program, Henry Ford Health System, 1 Ford Place, Detroit, Minnesota 48202, USACongcong Yin, Li Zhou & Qing-Sheng MiDepartment of Endocrinology, Fujian Provincial Hospital, Fujian Medical University ... ScholarSearch for Gang Chen in:Nature Research journals • PubMed • Google ScholarSearch for Yangang Wang in:Nature Research journals • PubMed • Google ScholarSearch for Li Zhou in:Nature Research journals

Meta-Analysis of Microarray Studies Reveals a Novel Hematopoietic Progenitor Cell Signature and Demonstrates Feasibility of Inter-Platform Data Integration

Microarray-based studies of global gene expression (GE) have resulted in a large amount of data that can be mined for further insights into disease and physiology. Meta-analysis of these data is hampered by technical limitations due to many different platforms, gene annotations and probes used in different studies. We tested the feasibility of conducting a meta-analysis of GE...

Widespread Hypomethylation Occurs Early and Synergizes with Gene Amplification during Esophageal Carcinogenesis

Although a combination of genomic and epigenetic alterations are implicated in the multistep transformation of normal squamous esophageal epithelium to Barrett esophagus, dysplasia, and adenocarcinoma, the combinatorial effect of these changes is unknown. By integrating genome-wide DNA methylation, copy number, and transcriptomic datasets obtained from endoscopic biopsies of...

A Genome Wide Association Study Identifies Common Variants Associated with Lipid Levels in the Chinese Population

DY XY JS YG HZ XQ Jingwen Zhu X. Min JC WT Yiqin Wang SW XD Dongfeng Lin. Wrote the manuscript: LZ MH FBH TW. Conceived and designed the experiments: LZ(Li Zhou) ZM(Zengnan Mo) XZ(Xiaomin Zhang) XL(Xu ... (Yuan Liang)) QD(Qifei Deng) SH(Suli Huang)) SLZ(S.Lilly Zheng)) Analyzed Data: LZ(Li Zhou) MH(Meian He) YH(Yunfeng Wei)) XM(Xiaoping Miao) FW( Feng Guo) TW(Tangchun Wu) Contributed reagents

Tubular ischemia and toxicity

Introduction and Aims: Endothelial progenitor cells (EPCs) are bone marrow-derived precursors known to reverse acute kidney injury (AKI) by paracrine mechanisms including the release of extracellular vesicles (EVs), small particles playing a role in intercellular communication through the transfer of proteins and RNAs. Activation of the complement cascade in tubular epithelial...

Mice deficient in the candidate tumor suppressor gene Hic1 exhibit developmental defects of structures affected in the Miller–Dieker syndrome

HIC1 is a candidate tumor suppressor gene which is frequently hypermethylated in human tumors, and its location within the Miller–Dieker syndrome’s critical deletion region at chromosome 17p13.3 makes it a candidate gene for involvement in this gene deletion syndrome. To study the function of murine Hic1 in development, we have created Hic1-deficient mice. These animals die...

Blockade of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Exacerbates Type 1 Diabetes in NOD Mice

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is expressed in different tissues and cells, including pancreas and lymphocytes, and can induce apoptosis in various tumor cells but not in most normal cells. The specific roles of TRAIL in health and disease remain unclear. Here we show by cDNA array analyses that TRAIL gene expression is upregulated in...

Genotypic variants at 2q33 and risk of esophageal squamous cell carcinoma in China: a meta-analysis of genome-wide association studies

Genome-wide association studies have identified susceptibility loci for esophageal squamous cell carcinoma (ESCC). We conducted a meta-analysis of all single-nucleotide polymorphisms (SNPs) that showed nominally significant P-values in two previously published genome-wide scans that included a total of 2961 ESCC cases and 3400 controls. The meta-analysis revealed five SNPs at...