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Evaluation of Human Leukocyte Antigen-A (HLA-A), Other Non-HLA Markers on Chromosome 6p21 and Risk of Nasopharyngeal Carcinoma

Background The association between human leukocyte antigen (HLA) genes (located in the Major Histocompatibility Complex [MHC] region of chromosome 6p21) and NPC has been known for some time. Recently, two genome-wide association studies (GWAS) conducted in Taiwan and China confirmed that the strongest evidence for NPC association was mapped to the MHC region. It is still unclear...

Transcriptome coexpression map of human embryonic stem cells

Background Human embryonic stem (ES) cells hold great promise for medicine and science. The transcriptome of human ES cells has been studied in detail in recent years. However, no systematic analysis has yet addressed whether gene expression in human ES cells may be regulated in chromosomal domains, and no chromosomal domains of coexpression have been identified. Results We...

Electroporation-mediated and EBV LMP1-regulated gene therapy in a syngenic mouse tumor model

Latent membrane protein 1 (LMP1) is an Epstein–Barr virus (EBV)-encoded oncogene expressed in EBV-associated nasopharyngeal carcinoma (NPC). Previous studies indicate that a strategy combining LMP1-mediated NF-κB activation and the HSV thymidine kinase/Ganciclovir (HSVtk/GCV) prodrug system leads to regression of tumor growth in nude mice. To improve the efficacy of this strategy...

Genetic diversity and evolutionary dynamics of Ebola virus in Sierra Leone

Laboratory of Pathogen and Biosecurity, Beijing 100071, ChinaYi-Gang Tong, Long Liang, Hong-Guang Ren, Hang Fan, Yuan Jin, Yue Teng, Yi Hu, Yong-Qiang Deng, Yu Sun, Zhuang Wang, Chun-Hua Sun, Xiao-Ping An ... 100071, China.Yi-Gang Tong, Yi Hu, Yong-Qiang Deng, Yu Sun, Zhuang Wang, Chun-Hua Sun & Jia-Fu JiangKey Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun 130122, China.Jun Qian

Functional characterization of Trip10 in cancer cell growth and survival

Background The Cdc42-interacting protein-4, Trip10 (also known as CIP4), is a multi-domain adaptor protein involved in diverse cellular processes, which functions in a tissue-specific and cell lineage-specific manner. We previously found that Trip10 is highly expressed in estrogen receptor-expressing (ER+) breast cancer cells. Estrogen receptor depletion reduced Trip10 expression...

Induction of inducible nitric oxide synthase by Epstein-Barr virus B95-8-derived LMP1 in Balb/3T3 cells promotes stress-induced cell death and impairs LMP1-mediated transformation

The latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV) causes cellular transformation and activation of several intracellular signaling events. In this report, we show that BLMP1 (encoded by the LMP1 gene derived from the B95-8 strain of EBV) triggers the expression of inducible nitric oxide synthase (iNOS) in Balb/3T3 fibroblasts. Intriguingly, NLMP1, a natural...

Erratum: Genetic diversity and evolutionary dynamics of Ebola virus in Sierra Leone

-Xiang Su Yu Sun Wen-Sen Liu Zhuang Wang Cheng-Yu Wang Zhao-Yang Bu Zhen-Dong Guo Liu-Bo Zhang Wei-Min Nie Chang-Qing Bai Chun-Hua Sun Xiao-Ping An Pei-Song Xu Xiang-Li-Lan Zhang Yong Huang Zhi-Qiang Mi

TUMOR MODELS (IN VIVO/IN VITRO)

Science is based on the experimental method since the time of Galileo and Descartes. Even the most brilliant theories and hypothesis must be experimentally verified. The general theory of relativity gained its magnificence only after the solar eclipse of 1919 confirmed the deflection of light experimentally. From that moment, the theory that the space-time bends became reality...

TUMOUR BIOLOGY

DIG (Desmoplastic Infantile Ganglioglioma) is a rare intracranial neoplasm classified as WHO grade I tumor under neuronal and mixed neuronal glial tumors (under 2007 World Health Organization brain tumor classification). It is usually considered to have a good prognosis but 40% of the cases require additional medical, radiation and/or further surgical intervention and 15% of...

LOW GRADE GLIOMAS

. LG-024. TARGETING BRAF MUTANTS FOR PEDIATRIC LOW-GRADE ASTROCYTOMAS Yu Sun, Sara Buhrlage, Catherine Pilarz, John Alberta, Charles Stiles, and Nathanael Gray; Dana-Farber Cancer Institute, Boston, MA

CELL BIOLOGY AND SIGNALING

Ikaros, a DNA-binding protein also known as Ikaros family zinc finger protein 1 (IKZF1), was initially shown to function critically in hematopoietic differentiation. Deletion or mutation of Ikaros has been associated with lymphoblastic, as well as acute and chronic myelogenous leukemias demonstrating that Ikaros can act as a tumor suppressor. Ikaros is predominantly expressed in...