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Molecular epidemiology of drug resistance markers of Plasmodium falciparum in Yunnan Province, China

BackgroundThe mutations in Plasmodium falciparum chloroquine resistance transporter (pfcrt), multidrug resistance 1 (pfmdr1), dihydrofolate reductase (pfdhfr), dihydropteroate synthase (pfdhps) and ATPase (pfatp6) genes were associated with anti-malaria drug resistance. The aim of this study was to investigate the prevalence of polymorphisms in pfcrt, pfmdr1, pfdhfr, pfdhps and...

Relationship of tumor marker CA125 and ovarian tumor stem cells: preliminary identification

Purpose The purpose of this study is to identify a prospective association between CA125 and tumorigenic ovarian cancer cells, using the new method of orthotopic transplantation (1). Method After making the surgical ovarian cancer specimen into cell suspension, we separated the tumorigenic cells from the nontumorigenic cancer cells based on cell surface marker (cancer antigen...

The Treg/Th17 Imbalance in Patients with Obstructive Sleep Apnoea Syndrome

Obstructive sleep apnoea syndrome (OSAS) is a chronic inflammatory disease regulated by T lymphocytes. Our purpose is to assess the pattern of Th17 cells and CD4

The Complete Mitochondrial Genome and Novel Gene Arrangement of the Unique-Headed Bug Stenopirates sp. (Hemiptera: Enicocephalidae)

Many of true bugs are important insect pests to cultivated crops and some are important vectors of human diseases, but few cladistic analyses have addressed relationships among the seven infraorders of Heteroptera. The Enicocephalomorpha and Nepomorpha are consider the basal groups of Heteroptera, but the basal-most lineage remains unresolved. Here we report the mitochondrial...

Beneficial Effects of Wheat Gluten Hydrolysate to Extend Lifespan and Induce Stress Resistance in Nematode Caenorhabditis elegans

Previous studies have showed that wheat gluten hydrolysate (WGH) has the anti-oxidative property. In the present study, we examined the possible safety property of WGH and the beneficial effects of WGH to extend lifespan and induce stress resistance using nematode Caenorhabditis elegans as the in vivo assay system. We found that WGH at concentrations of 0.1–1 mg/mL did not cause...

Differential Modulation of Photosynthesis, Signaling, and Transcriptional Regulation between Tolerant and Sensitive Tomato Genotypes under Cold Stress

The wild species Solanum habrochaites is more cold tolerant than the cultivated tomato (S. lycopersicum). To explore the mechanisms underlying cold tolerance of S. habrochaites, seedlings of S. habrochaites LA1777 introgression lines (ILs), as well as the two parents, were evaluated under low temperature (4°C). The IL LA3969 and its donor parent LA1777 were found to be more cold...

Reducing AsA Leads to Leaf Lesion and Defence Response in Knock-Down of the AsA Biosynthetic Enzyme GDP-D-Mannose Pyrophosphorylase Gene in Tomato Plant

As a vital antioxidant, L-ascorbic acid (AsA) affects diverse biological processes in higher plants. Lack of AsA in cell impairs plant development. In the present study, we manipulated a gene of GDP-mannose pyrophosphorylase which catalyzes the conversion of D-mannose-1-P to GDP-D-mannose in AsA biosynthetic pathway and found out the phenotype alteration of tomato. In the tomato...

Increased Frequency of Bone Marrow T Follicular Helper Cells in Patients with Immune-Related Pancytopenia

Immune-related pancytopenia (IRP) is one kind of bone marrow failure diseases which is related to autoantibodies. Autoantibodies have been detected on the membrane of various bone marrow (BM) hemopoietic cells by BM mononuclear-cell-Coombs test or flow cytometric analysis. There are autoantibodies in the BM supernatant of IRP patients, which can target several antigens on...

Increased Frequency of Bone Marrow T Follicular Helper Cells in Patients with Immune-Related Pancytopenia

Immune-related pancytopenia (IRP) is one kind of bone marrow failure diseases which is related to autoantibodies. Autoantibodies have been detected on the membrane of various bone marrow (BM) hemopoietic cells by BM mononuclear-cell-Coombs test or flow cytometric analysis. There are autoantibodies in the BM supernatant of IRP patients, which can target several antigens on...

Broadcast Network Coverage with Multicell Cooperation

Multicell cooperation has been identified as one of the underlying principles for future wireless communication systems. This paper studies the benefits of multicell cooperation in broadcast TV network from an information theoretical perspective. We define outage capacity as the figure of merit and derive the broadcast coverage area to evaluate such system. Specifically, we...

Broadcast Network Coverage with Multicell Cooperation

Multicell cooperation has been identified as one of the underlying principles for future wireless communication systems. This paper studies the benefits of multicell cooperation in broadcast TV network from an information theoretical perspective. We define outage capacity as the figure of merit and derive the broadcast coverage area to evaluate such system. Specifically, we...

miRFANs: an integrated database for Arabidopsis thaliana microRNA function annotations

Background Plant microRNAs (miRNAs) have been revealed to play important roles in developmental control, hormone secretion, cell differentiation and proliferation, and response to environmental stresses. However, our knowledge about the regulatory mechanisms and functions of miRNAs remains very limited. The main difficulties lie in two aspects. On one hand, the number of...

Maternal and fetal plasma platelet-activating factor acetylhydrolase activity and distribution in pre-eclampsia

BaiDepartment of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Sichuan, People’s Republic of ChinaXing-Hui Liu, Guo-Lin He & Shuo Zhang AuthorsSearch for Ping Fan in:Nature ... Research journals • PubMed • Google ScholarSearch for Xing-Hui Liu in:Nature Research journals • PubMed • Google ScholarSearch for Guo-Lin He in:Nature Research journals • PubMed • Google ScholarSearch for

In vitro anti-angiogenic properties of LGD1069, a selective retinoid X-receptor agonist through down-regulating Runx2 expression on Human endothelial cells

Background LGD1069 (Targretin®) is a selective retinoid X receptor (RXR) ligand, which is used in patients for cutaneous T-cell lymphoma. Our published study reported that LGD1069 inhibited tumor-induced angiogenesis in non-small cell lung cancer. In present study, we found that LGD1069 suppressed the proliferation, adhesion, invasion and migration of endothelial cells directly...

Myocardial triglyceride content at 3 T cardiovascular magnetic resonance and left ventricular systolic function: a cross-sectional study in patients hospitalized with acute heart failure

Background Increased myocardial triglyceride (TG) content has been recognized as a risk factor for cardiovascular disease. However, its relation with cardiac function in patients on recovery from acute heart failure (HF) remains unclear. In this cross-sectional study, we sought to investigate the association between myocardial TG content measured on magnetic resonance...

Prediction of novel long non-coding RNAs based on RNA-Seq data of mouse Klf1 knockout study

Hui Liu 0 0 School of Information and Electrical Engineering, China University of Mining and Technology , Xuzhou, JiangSu 221008 , PR China Background: Study on long non-coding RNAs (lncRNAs) has been

RUNX3 Suppresses Migration, Invasion and Angiogenesis of Human Renal Cell Carcinoma

RUNX3 (runt-related transcription factor-3) is a known tumor suppressor gene which exhibits potent antitumor activity in several carcinomas. However, little is known about the role of RUNX3 in human renal cell carcinoma (RCC). To investigate the clinical relevance of RUNX3 in RCC patients, immunohistochemistry was performed to detect the clinical relevance of RUNX3 in 75 RCC...

Characterization of a novel mouse model with genetic deletion of CD177

Tygrett, Thomas Waldschmidt, Alicia Olivier, Songhai Chen, Guang-Hui Liu, Xiangrui Li, and Weizhou Zhang declare that they have no conflict of interest. This article does not contain any studies with human

Comparison of the Efficacy of Rosuvastatin versus Atorvastatin in Preventing Contrast Induced Nephropathy in Patient with Chronic Kidney Disease Undergoing Percutaneous Coronary Intervention

Objectives We prospectively compared the preventive effects of rosuvastatin and atorvastatin on contrast-induced nephropathy (CIN) in patients with chronic kidney disease (CKD) undergoing percutaneous coronary intervention (PCI). Methods We enrolled 1078 consecutive patients with CKD undergoing elective PCI. Patients in Group 1 (n = 273) received rosuvastatin (10 mg), and those...

A top–down strategy towards monodisperse colloidal lead sulphide quantum dots

, Tianjin University, Tianjin 300072, People’s Republic of ChinaJing Yang, Tao Ling, Wen-Tian Wu, Hui Liu, Min-Rui Gao, Chen Ling & Xi-Wen DuKey Laboratory of Display Materials and Photoelectric Devices ... • PubMed • Google ScholarSearch for Hui Liu in:Nature Research journals • PubMed • Google ScholarSearch for Min-Rui Gao in:Nature Research journals • PubMed • Google ScholarSearch for Chen Ling in:Nature