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Additive effect of LRP8/APOER2 R952Q variant to APOE ε2/ε3/ε4 genotype in modulating apolipoprotein E concentration and the risk of myocardial infarction: a case-control study

Background The R952Q variant in the low density lipoprotein receptor-related protein 8 (LRP8)/apolipoprotein E receptor 2 (ApoER2) gene has been recently associated with familial and premature myocardial infarction (MI) by means of genome-wide linkage scan/association studies. We were interested in the possible interaction of the R952Q variant with another established...

The anti-endotoxic effect of o-aminobenzoic acid from Radix Isatidis

Aim:To study the anti-endotoxic effect of o-aminobenzoic acid (OABA) isolated from Banlangen(BLG).Methods:OABA was extracted and isolated from BLG and diluted into 0.5% solution. The concentration of endotoxin (ET) pretreated with OABA was quantitatively detected using Limulus test. The inhibition of ET-induced fever by OABA was measured in rabbits. The rates of...

Preparation, Structure, and Properties of a Novel Rectorite/Nitrile Butadiene Rubber (NBR) Nanocomposites

Rectorite/nitrile butadiene rubber (NBR) nanocomposite was firstly prepared by co-coagulating NBR latex and rectorite water suspension. The microstructure of the resulted nanocomposite was characterized by transmission electron microscopy (TEM) and X-ray diffraction (XRD). The results indicated that the rectorite layers were dispersed in the NBR matrix in form of single layers...

The Wilms Tumor Gene, Wt1, Is Critical for Mouse Spermatogenesis via Regulation of Sertoli Cell Polarity and Is Associated with Non-Obstructive Azoospermia in Humans

Azoospermia is one of the major reproductive disorders which cause male infertility in humans; however, the etiology of this disease is largely unknown. In the present study, six missense mutations of WT1 gene were detected in 529 human patients with non-obstructive azoospermia (NOA), indicating a strong association between WT1 mutation and NOA. The Wilms tumor gene, Wt1, is...

Aberrant Expression of miR-638 Contributes to Benzo(a)pyrene-Induced Human Cell Transformation

Identification of aberrant microRNA (miRNA) expression during chemical carcinogen–induced cell transformation will lead to a better understanding of the substantial role of miRNAs in cancer development. To explore whether aberrant miRNAs expression can be used as biomarkers of chemical exposure in risk assessment of chemical carcinogenesis, we analyzed miRNA expression profiles...

Transcription factor MEF2A mutations in patients with coronary artery disease

Coronary artery disease (CAD), including its most serious complication myocardial infraction (MI), is the leading cause of death in the US and developed countries. We recently discovered that a seven-amino acid deletion in MEF2A, a transcription factor with a high level of expression in the endothelium of coronary arteries, co-segregates with CAD/MI in one family, and it...

Enhanced surveillance of acute flaccid paralysis following importation of wild poliovirus in Xinjiang Uygur Autonomous Region, China

Background After being polio free for more than 10 years, an outbreak occurred in China in 2011 in Xinjiang Uygur Autonomous Region (Xinjiang) following the importation of wild poliovirus (WPV) originating from neighboring Pakistan. Methods To strengthen acute flaccid paralysis (AFP) surveillance in Xinjiang, “zero case daily reporting” and retrospective searching of AFP cases...

Structure-efficacy relationships of immunostimulatory activity of CpG-containing oligodeoxynucleotides on mouse spleen cells

Aim:To study the relationship between primary structures of oligodeoxynucleo-tides (ODN) containing unmethylated deoxycytidyl-deoxyguanosine (CpG) dinucleotide motifs and their immunostimulatory activities in mouse spleen cells.Methods:A series of CpG ODN with different primary structures were synthesized. Their capabilities to stimulate mouse spleen cell proliferation were...

Expression of the interleukin-21 gene in murine colon carcinoma cells generates systemic immunity in the inoculated hosts

Interleukin-21 (IL-21) is a novel cytokine that can induce proliferation of activated T cells and maturation of natural killer (NK) cells. We therefore examined whether expression of the IL-21 gene in tumor cells could generate antitumor responses. Murine colon carcinoma Colon 26 cells that were transduced with the mouse IL-21 gene (Colon 26/IL-21) were rejected in syngeneic mice...

Alterations of anaphase-promoting complex genes in human colon cancer cells

, CNRS UPR 1086, 1919 route de Mende, 34293 Montpellier, Cedex 5, FranceThierry Lorca AuthorsSearch for Qing Wang in:Nature Research journals • PubMed • Google ScholarSearch for Caroline Moyret-Lalle

Towards precise classification of cancers based on robust gene functional expression profiles

the field datasets. JZ, HW, CW, EJT and QW (Qing Wang) implemented the search for biological knowledge support and provided constructive advice for the biological interpretation of the results. All

Genetic linkage analysis of longitudinal hypertension phenotypes using three summary measures

Background Longitudinal data often have multiple (repeated) measures recorded along a time trajectory. For example, the two cohorts from the Framingham Heart Study (GAW13 Problem 1) contain 21 and 5 repeated measures for hypertension phenotypes as well as epidemiological risk factors, respectively. Direct modelling of a large number of serially and biologically correlated traits...

A Rapid Immune Response to 2009 Influenza A(H1N1) Vaccines in Adults: A Randomized, Double-Blind, Controlled Trial

A double-blind, randomized, controlled trial involving 706 adults was conducted to evaluate the immunogenicity and safety of different dosages of whole-virion or split-virion H1N1 influenza vaccines with or without aluminum adjuvant. A rapid and strong immune response was induced at day 14 after the first injection. The seroprotection rates ranged from 72.7% (95% confidence...

Clinical relevance of 8q23, 15q13 and 18q21 SNP genotyping to evaluate colorectal cancer risk

Brugières in:Nature Research journals • PubMed • Google ScholarSearch for Qing Wang in:Nature Research journals • PubMed • Google ScholarSearch for Brigitte Bressac-de Paillerets in:Nature Research journals

T-cell-dependent antitumor effects produced by CD40 ligand expressed on mouse lung carcinoma cells are linked with the maturation of dendritic cells and secretion of a variety of cytokines

Shimozato, Yan-Qing Wang, Shigeru Sakiyama & Masatoshi TagawaDepartment of Respirology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, JapanYuji Tada, Yuichi Takiguchi ... Shimozato in:Nature Research journals • PubMed • Google ScholarSearch for Yan-Qing Wang in:Nature Research journals • PubMed • Google ScholarSearch for Yuichi Takiguchi in:Nature Research journals • PubMed

Multivariate sib-pair linkage analysis of longitudinal phenotypes by three step-wise analysis approaches

Background Current statistical methods for sib-pair linkage analysis of complex diseases include linear models, generalized linear models, and novel data mining techniques. The purpose of this study was to further investigate the utility and properties of a novel pattern recognition technique (step-wise discriminant analysis) using the chromosome 10 linkage data from the...

Multivariate sib-pair linkage analysis of longitudinal phenotypes by three step-wise analysis approaches

Current statistical methods for sib-pair linkage analysis of complex diseases include linear models, generalized linear models, and novel data mining techniques. The purpose of this study was to further investigate the utility and properties of a novel pattern recognition technique (step-wise discriminant analysis) using the chromosome 10 linkage data from the Framingham Heart...

Polycations and cationic lipids enhance adenovirus transduction and transgene expression in tumor cells

Replication-deficient adenovirus vectors are efficient vehicles for delivering therapeutic genes into mammalian cells. However, the high doses required to produce effective gene transfer in vivo can also cause unwanted cellular toxicity. To improve replication-deficient adenovirus transgene expression while minimizing adverse reactions, we have tested polycationic compounds for...