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Mutation detection in Chinese patients with familial hypercholesterolemia

BackgroundFamilial hypercholesterolemia (FH) is the first molecularly and clinically characterized genetic disease of lipid metabolism. It is an autosomal dominant disorder with significantly elevated levels of total cholesterol and low density of lipoprotein cholesterol in serum, which would lead to extensive xanthomas and premature coronary heart disease. Mutations in low...

Whole genome shotgun sequence of Bacillus amyloliquefaciens TF28, a biocontrol entophytic bacterium

Bacillus amyloliquefaciens TF28 is a biocontrol endophytic bacterium that is capable of inhibition of a broad range of plant pathogenic fungi. The strain has the potential to be developed into a biocontrol agent for use in agriculture. Here we report the whole-genome shotgun sequence of the strain. The genome size of B. amyloliquefaciens TF28 is 3,987,635 bp which consists of...

Complete genome sequence of the molybdenum-resistant bacterium Bacillus subtilis strain LM 4–2

Bacillus subtilis LM 4–2, a Gram-positive bacterium was isolated from a molybdenum mine in Luoyang city. Due to its strong resistance to molybdate and potential utilization in bioremediation of molybdate-polluted area, we describe the features of this organism, as well as its complete genome sequence and annotation. The genome was composed of a circular 4,069,266 bp chromosome...

Study of the reparative effects of menstrual-derived stem cells on premature ovarian failure in mice

Background Young female patients who receive chemotherapy frequently face premature ovarian failure (POF). The therapeutic potential of stem cells in these patients has been explored in stem cells derived from different sources. However, many of these types of stem cells are either difficult to obtain or obtaining them involves invasive procedures. Here, we show that menstrual...

Erratum to: Study of the reparative effects of menstrual-derived stem cells on premature ovarian failure in mice

Li 0 Xinyuan Yang 1 0 Center for Translational Medicine, First Affiliated Hospital of Xi'an Jiaotong University , Xi'an 710061 , People's Republic of China 1 Department of Gynecology and Obstetrics

Comparative analysis of human mesenchymal stem cells from bone marrow and adipose tissue under xeno-free conditions for cell therapy

Introduction Mesenchymal stem cells (MSCs) are promising candidates for cell-based therapies. Human platelet lysate represents an efficient alternative to fetal bovine serum for clinical-scale expansion of MSCs. Different media used in culture processes should maintain the biological characteristics of MSCs during multiple passages. However, bone marrow-derived MSCs and adipose...

Exploring the anomalous top–Higgs FCNC couplings at the electron proton colliders

We perform an updated analysis on the searches for the anomalous FCNC Yukawa interactions between the top quark, the Higgs boson, and either an up or charm quark \({{tqh,\ q=u,\ c}}\)). We probe the observability of the FCNC top–Higgs couplings through the processes \({e^- p\rightarrow \nu _{\mathrm{e}} }\bar{{t}} \rightarrow \nu _{\mathrm{e}} h \bar{{q}}\) signal I) and \(e^- p...

Emergy Analysis of Biogas Systems Based on Different Raw Materials

Environmental pollution and energy crisis restrict the development of China, and the utilization of renewable technology is an effective strategy to alleviate the damage. Biogas engineering has rapidly developed attributes to solve environmental problems and create a renewable energy product biogas. In this paper, two different biogas plants’ materials were analyzed by emergy...

Emergy Analysis of Biogas Systems Based on Different Raw Materials

Environmental pollution and energy crisis restrict the development of China, and the utilization of renewable technology is an effective strategy to alleviate the damage. Biogas engineering has rapidly developed attributes to solve environmental problems and create a renewable energy product biogas. In this paper, two different biogas plants’ materials were analyzed by emergy...

Quality of reporting of trial abstracts needs to be improved: using the CONSORT for abstracts to assess the four leading Chinese medical journals of traditional Chinese medicine

: 880 - 887 . 12. Xiao-li Zhang , Jing Li , Ming-ming Zhang, Wen-ming Yuan: Assessing the Reporting Quality of Randomized Controlled Trials on Acupuncture for Acute Ischemic Stroke Using the CONSORT

Hepatitis C virus promotes hepatocellular carcinogenesis by targeting TIPE2, a new regulator of DNA damage response

Infection of hepatitis C virus (HCV) is associated with primary hepatocellular carcinoma (HCC). However, its underlying molecular mechanisms remain enigmatic. Tumor necrosis factor-α-induced protein 8-like 2 (TIPE2), a new negative regulator of immunity, plays significant roles in modulating inflammation and tumorigenesis. We hypothesized that TIPE2 might be involved in the...

Study on the Ownership of Motorized and Non-motorized Vehicles in Suburban Metro Station Areas: A Structural Equation Approach

As Chinese megacities are experiencing a large-scale motorization and suburbanization, an ever greater number of households are relocated to suburban towns. The increasing average travel distance surely encourages car growth. China is now the world’s largest car consumer, resulting in a series of unforeseen environmental and public health issues. On the other hand, scooters...

Porcine circovirus type 2 in China: an update on and insights to its prevalence and control

Currently, porcine circovirus type 2 (PCV2) is considered the major pathogen of porcine circovirus associated-diseases (PCVAD) that causes large economic losses for the swine industry in the world annually, including China. Since the first report of PCV2 in 1998, it has been drawing tremendous attention for the government, farming enterprises, farmers, and veterinary...

Development of an ELISA-array for simultaneous detection of five encephalitis viruses

Japanese encephalitis virus(JEV), tick-borne encephalitis virus(TBEV), and eastern equine encephalitis virus (EEEV) can cause symptoms of encephalitis. Establishment of accurate and easy methods by which to detect these viruses is essential for the prevention and treatment of associated infectious diseases. Currently, there are still no multiple antigen detection methods...

A new treatment for neurogenic inflammation caused by EV71 with CR2-targeted complement inhibitor

Background Enterovirus 71 (EV71), one of the most important neurotropic EVs, has caused death and long-term neurological sequelae in hundreds of thousands of young children in the Asia-Pacific region in the past decade. The neurological diseases are attributed to infection by EV71 inducing an extensive peripheral and central nervous system (CNS) inflammatory response with...

Novel genetic reassortants in H9N2 influenza A viruses and their diverse pathogenicity to mice

H9N2 influenza A viruses have undergone extensive reassortments in different host species, and could lead to the epidemics or pandemics with the potential emergence of novel viruses. To understand the genetic and pathogenic features of early and current circulating H9N2 viruses, 15 representative H9N2 viruses isolated from diseased chickens in northern China between 1998 and 2010...

Virulence of H5N1 virus in mice attenuates after in vitro serial passages

The virulence of A/Vietnam/1194/2004 (VN1194) in mice attenuated after serial passages in MDCK cells and chicken embryos, because the enriched large-plaque variants of the virus had significantly reduced virulence. In contrast, the small-plaque variants of the virus and the variants isolated from the brain of mice that were infected with the parental virus VN1194 had much higher...

Novel genetic reassortants in H9N2 influenza A viruses and their diverse pathogenicity to mice

Background H9N2 influenza A viruses have undergone extensive reassortments in different host species, and could lead to the epidemics or pandemics with the potential emergence of novel viruses. Methods To understand the genetic and pathogenic features of early and current circulating H9N2 viruses, 15 representative H9N2 viruses isolated from diseased chickens in northern China...