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The BET inhibitor I-BET762 inhibits pancreatic ductal adenocarcinoma cell proliferation and enhances the therapeutic effect of gemcitabine

Chenhai Liu Zhen Liu Futao Meng Chao Wang Qiang Huang OPEN As one of the most fatal malignancies, pancreatic ductal adenocarcinoma (PDAC) has significant resistance to the currently available treatment

A matched space for time scales and applications to the study on functions

’ insightful comments to improve this manuscript. This work was done while Chao Wang was a visiting scholar at Texas A&M University-Kingsville. This work is supported by Youth Fund of NSFC (No. 11601470), Tian

The effect of V2O5-WO3-TiO2 electrode thickness on ammonia sensing properties for potentiometric sensor

SCR catalyst V2O5-WO3-TiO2 was synthesized for fabricating sensing electrodes of potentiometric ammonia sensor in this work. As an important sensing electrode structural parameter, the influence of the electrode thickness on sensor properties was investigated. The VWT electrodes with the thickness of 9.8, 15.2 and 24.5μm were made by different screen printing frequency. As the...

Evaporative deposition of polystyrene microparticles on PDMS surface

Evaporation of water and ethanol/water droplets containing large polystyrene (PS) microparticles on polydimethylsiloxane (PDMS) surface was experimentally investigated. It is found that no matter with or without small addition of ethanol, a compact monolayer deposition is formed for lower microparticle concentration while mountain-like deposition for higher concentration. Since...

Finite-Time Nonfragile Synchronization of Stochastic Complex Dynamical Networks with Semi-Markov Switching Outer Coupling

Kaviarasan 2 Chao Wang 3 Yong-Ki Ma 4 Hiroki Sayama 0 Department of Mathematics, Bharathiar University , Coimbatore 641046 , India 1 Department of Mathematics, Sungkyunkwan University , Suwon 440-746

The Hsp70 inhibitor 2-phenylethynesulfonamide inhibits replication and carcinogenicity of Epstein–Barr virus by inhibiting the molecular chaperone function of Hsp70

Epstein–Barr virus (EBV) can infect cells in latent and lytic period and cause serious disease. Epstein–Barr virus nuclear antigen 1 (EBNA1) is essential for the maintenance of the EBV DNA episome, replication and transcription. 2-phenylethynesulfonamide (PES) is a small molecular inhibitor of Heat shock protein 70 (Hsp70), which can interact with Hsp70 and disrupts its...

Risk-Field Based Modeling for Pedestrian Emergency Evacuation Combined with Alternative Route Strategy

, Shanghai 201804, China Correspondence should be addressed to Chao Wang; nc.ude.ijgnot@oahcgnaw608098 Received 20 December 2016; Revised 22 March 2017; Accepted 2 April 2017; Published 20 April 2017 ... Academic Editor: Antonio Bilotta Copyright © 2017 Chao Wang and Jian Wang. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use

Risk-Field Based Modeling for Pedestrian Emergency Evacuation Combined with Alternative Route Strategy

, Shanghai 201804, China Correspondence should be addressed to Chao Wang; nc.ude.ijgnot@oahcgnaw608098 Received 20 December 2016; Revised 22 March 2017; Accepted 2 April 2017; Published 20 April 2017 ... Academic Editor: Antonio Bilotta Copyright © 2017 Chao Wang and Jian Wang. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use

The prognostic values of the expression of Vimentin, TP53, and Podoplanin in patients with cervical cancer

Epithelial–mesenchymal transition (EMT), TP53, and Podoplanin have been implicated in the tumorigenesis and metastasis of human cancers. Nevertheless, the clinical significance of these markers in cancer patients is still not clear. In this study, we sought to determine the prognostic values of Vimentin, TP53, and Podoplanin in patients with cervical cancer. Quantitative real...

Role of intestinal trefoil factor in protecting intestinal epithelial cells from burn-induced injury

Although intestinal trefoil factor (ITF) can alleviate the burn-induced intestinal mucosa injury, the underlying mechanisms remains elusive. In this study, we investigated if ITF alters glutamine transport on the brush border membrane vesicles (BBMVs) of the intestines in Sprague-Dawley rats inflicted with 30% TBSA and the underlying mechanisms. We found that ITF significantly...

Probing into the Mechanism of Alkaline Citrus Extract Promoted Apoptosis in Pulmonary Fibroblasts of Bleomycin-Induced Pulmonary Fibrosis Mice

Wang,1 and Xian-mei Zhou1,2 1Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China 2Department of Respiratory Medicine, Jiangsu Province Hospital of Traditional Chinese

Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity

Oridonin (Ori) is the major active ingredient of the traditional Chinese medicinal herb Rabdosia rubescens and has anti-inflammatory activity, but the target of Ori remains unknown. NLRP3 is a central component of NLRP3 inflammasome and has been involved in a wide variety of chronic inflammation-driven human diseases. Here, we show that Ori is a specific and covalent inhibitor...

Feature-based RGB-D camera pose optimization for real-time 3D reconstruction

. Chao Wang is currently a Ph.D. candidate in the Department of Computer Science at the University of Texas at Dallas. Before that, he received his M.S. degree in computer science in 2012, and B.S. degree

Dual-linker gold nanoparticles as adjuvanting carriers for multivalent display of recombinant influenza hemagglutinin trimers and flagellin improve the immunological responses in vivo and in vitro

Chao Wang, Wandi Zhu, Bao-Zhong Wang Center for Inflammation, Immunity and Infection, Georgia State University Institute for Biomedical Sciences, Atlanta, GA, USA Abstract: Vaccination is the most cost ... immunological responses in vivo and in vitro Chao Wang Wandi Zhu Bao-Zhong Wang 0 0 center for Inflammation , Immunity and Infection , georgia state University Institute for Biomedical sciences , atlanta, ga

Direct observation of tin sites and their reversible interconversion in zeolites by solid-state NMR spectroscopy

Metal-substituted zeolites are an important type of solid Lewis acid with a wide range of applications. Despite the importance of this type of catalyst, identifying active sites can be challenging because different types of metal sites experience similar environments in zeolites. Here we show direct observation of different tin sites in Sn-β zeolite. Two types of open tin sites...

Identification of a microRNA signature associated with survivability in cervical squamous cell carcinoma

Conceptualization: Chao Wang. Data curation: Qiongwei Wu, Guoying Lao. Formal analysis: Chengbin Ma. Investigation: Yu Liu. Methodology: Wenying Zhang, Qiongwei Wu, Chao Wang. Project administration: Ping Liu

Adaptive grid based multi-objective Cauchy differential evolution for stochastic dynamic economic emission dispatch with wind power uncertainty

curation: Chao Wang. Formal analysis: Xiangpeng Xie. Resources: Xiaohui Lei. Software: Chao Wang. Supervision: Dong Yue. Writing ± original draft: Huifeng Zhang. Writing ± review & editing: Xiaohui Lei

Evidence that CA3 is Underling the Comorbidity Between Pain and Depression and the Co-curation by Wu-Tou decoction in Neuropathic Pain

, China Academy of Chinese Medical Sciences, Beijing, 100700, ChinaChunyan Zhu, Qionghong Xu, Chao Wang, Zhiyun Mao & Na Lin AuthorsSearch for Chunyan Zhu in:Nature Research journals • PubMed • Google ... Scholar Search for Qionghong Xu in:Nature Research journals • PubMed • Google Scholar Search for Chao Wang in:Nature Research journals • PubMed • Google Scholar Search for Zhiyun Mao in:Nature Research

MiR-494-3p promotes PI3K/AKT pathway hyperactivation and human hepatocellular carcinoma progression by targeting PTEN

-chao Wang HuiYao Ke-zhu Hou Fang-ming Gu Xuan-fu Xu Recent studies have shown that miR-494-3p is oncogene and has a central role in many solid tumors; however, the role of miR-494-3p in the progression ... Foundation of China, No.: 81472689. Author Contributions Ke-zhu Hou, Fang-ming Gu and Xuan-fu Xu conceived the study and designed the experiments. Yuan-ping Tao, Meng-chao Wang and Hui Yao performed the