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A network-based biomarker approach for molecular investigation and diagnosis of lung cancer

Yu-Chao Wang 0 Bor-Sen Chen 0 0 Laboratory of Control and Systems Biology, Department of Electrical Engineering, National Tsing Hua University , Hsinchu 30013 , Taiwan Background: Lung cancer is

A new Monte Carlo mobile node localization algorithm based on Newton interpolation

There are some deficiencies in the Monte Carlo localization algorithm based on rangefinder, which like location probability distribution of the k moment in the prediction phase only related to the localization of the k − 1 moment and the maximum and minimum velocity. And the influences of the motion condition on the movement of the mobile node at k moment are also not considered...

A new measure of the robustness of biochemical networks

Motivation: The robustness of a biochemical network is defined as the tolerance of variations in kinetic parameters with respect to the maintenance of steady state. Robustness also plays an important role in the fail-safe mechanism in the evolutionary process of biochemical networks. The purposes of this paper are to use the synergism and saturation system (S-system...

A new technique for nanoparticle transport and its application in a novel nano-sieve

A new technique is proposed to transport and further classify nanoparticles of different sizes. A graphene sheet is used as the substrate; a nanoparticle is placed on the substrate and a sliding block is located below the substrate. As the sliding block moves under the graphene substrate, a driving force is yielded from the van der Waals interaction between the sliding block and...

A novel and fully automated mammographic texture analysis for risk prediction: results from two case-control studies

The percentage of mammographic dense tissue (PD) is an important risk factor for breast cancer, and there is some evidence that texture features may further improve predictive ability. However, relatively little work has assessed or validated textural feature algorithms using raw full field digital mammograms (FFDM). A case-control study nested within a screening cohort (age 46...

A novel autoantibody against moesin in the serum of patients with MPO-ANCA-associated vasculitis

Background Antineutrophil cytoplasmic autoantibody (ANCA) directed against myeloperoxidase (MPO), a diagnostic criterion in MPO-ANCA-associated vasculitis (MPO-AAV), does not always correlate with disease activity. Here, we detected autoantibodies against moesin, which was located on the surface of stimulated endothelial cells, in the serum of patients.

A novel perspective for burn-induced myopathy: Membrane repair defect

Myopathy is a common complication of severe burn patients. One potential cause of this myopathy could be failure of the plasma membrane to undergo repair following injuries generated from toxin or exercise. The aim of this study is to assess systemic effect on muscle membrane repair deficiency in burn injury. Skeletal muscle fibers isolated from burn-injured mice were damaged...

A novel recombinant 6Aβ15-THc-C chimeric vaccine (rCV02) mitigates Alzheimer’s disease-like pathology, cognitive decline and synaptic loss in aged 3 × Tg-AD mice

Alzheimer’s disease (AD) is a neurodegenerative disorder that impairs memory and cognition. Targeting amyloid-β (Aβ) may be currently the most promising immunotherapeutic strategy for AD. In this study, a recombinant chimeric 6Aβ15-THc-C immunogen was formulated with alum adjuvant as a novel Aβ B-cell epitope candidate vaccine (rCV02) for AD. We examined its efficacy in...

A rumor spreading model based on information entropy

Rumor spreading can have a significant impact on people’s lives, distorting scientific facts and influencing political opinions. With technologies that have democratized the production and reproduction of information, the rate at which misinformation can spread has increased significantly, leading many to describe contemporary times as a ‘post-truth era’. Research into rumor...

A simple, one-step hydrothermal approach to durable and robust superparamagnetic, superhydrophobic and electromagnetic wave-absorbing wood

In this work, lamellar MnFe2O4 was successfully planted on a wood surface through the association of hydrogen bonds via the one-pot hydrothermal method. Simultaneously, the fluoroalkylsilane (FAS-17) on the surface of the MnFe2O4 layer formed long-chain or network macromolecules through a poly-condensation process and provided a lower surface energy on the wood surface. The...

Ablation of protein phosphatase 5 (PP5) leads to enhanced both bone and cartilage development in mice

This study aimed to investigate the role of protein phosphatase 5 (PP5) on bone and cartilage development using both in vivo and in vitro approaches. Six- to 8-week- old male PP5 knockout mice (KO) and their wild-type (WT) littermate controls were randomly selected for this study, and their body weights and bone (femur) lengths were measured. Micro-computed tomography scanning...

Abstraction and mining of traces to explain concurrency bugs

We propose an automated mining-based method for explaining concurrency bugs. We use a data mining technique called sequential pattern mining to identify problematic sequences of concurrent read and write accesses to the shared memory of a multithreaded program. Our technique does not rely on any characteristics specific to one type of concurrency bug, thus providing a general...

Action Mechanisms of Lithium Chloride on Cell Infection by Transmissible Gastroenteritis Coronavirus

Transmissible gastroenteritis virus (TGEV) is a porcine coronavirus. Lithium chloride (LiCl) has been found to be effective against several DNA viruses, such as Herpes simplex virus and vaccinia virus. Recently, we and others have reported the inhibitory effect of LiCl on avian infectious bronchitis coronavirus (IBV) infection, an RNA virus. In the current study, the action...

Adaptive grid based multi-objective Cauchy differential evolution for stochastic dynamic economic emission dispatch with wind power uncertainty

curation: Chao Wang. Formal analysis: Xiangpeng Xie. Resources: Xiaohui Lei. Software: Chao Wang. Supervision: Dong Yue. Writing ± original draft: Huifeng Zhang. Writing ± review & editing: Xiaohui Lei

Adjuvant Chemotherapy, with or without Taxanes, in Early or Operable Breast Cancer: A Meta-Analysis of 19 Randomized Trials with 30698 Patients

Background Taxanes have been extensively used as adjuvant chemotherapy for the treatment of early or operable breast cancer, particularly in high risk, node-negative breast cancer. Previous studies, however, have reported inconsistent findings regarding their clinical efficacy and safety. We investigated disease-free survival (DFS), overall survival (OS), and drug-related...

Ag-Mg antisite defect induced high thermoelectric performance of α-MgAgSb

Engineering atomic-scale native point defects has become an attractive strategy to improve the performance of thermoelectric materials. Here, we theoretically predict that Ag-Mg antisite defects as shallow acceptors can be more stable than other intrinsic defects under Mg-poor‒Ag/Sb-rich conditions. Under more Mg-rich conditions, Ag vacancy dominates the intrinsic defects. The p...

Alfalfa (Medicago sativa L.)/Maize (Zea mays L.) Intercropping Provides a Feasible Way to Improve Yield and Economic Incomes in Farming and Pastoral Areas of Northeast China

Given the growing challenges to food and eco-environmental security as well as sustainable development of animal husbandry in the farming and pastoral areas of northeast China, it is crucial to identify advantageous intercropping modes and some constraints limiting its popularization. In order to assess the performance of various intercropping modes of maize and alfalfa, a field...

Almost Periodic Functions on Time Scales and Applications

May 2011 Academic Editor: Mingshu Peng Copyright © 2011 Yongkun Li and Chao Wang. This is an open access article distributed under the Creative Commons Attribution License, which permits

Almost Periodic Functions on Time Scales and Applications

May 2011 Academic Editor: Mingshu Peng Copyright © 2011 Yongkun Li and Chao Wang. This is an open access article distributed under the Creative Commons Attribution License, which permits