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New insights on the MMP-13 regulatory network in the pathogenesis of early osteoarthritis

Osteoarthritis (OA) is the most common joint disorder and affects approximately half of the aged population. Current treatments for OA are largely palliative until the articular cartilage has been deeply damaged and irreversible morphological changes appear. Thus, effective methods are needed for diagnosing and monitoring the progression of OA during its early stages when...

Is adjuvant chemotherapy beneficial for patients with FIGO stage IC adult granulosa cell tumor of the ovary?

To evaluate the association between adjuvant chemotherapy and clinical outcomes in patients with stage IC adult granulosa cell tumor (AGCT). We performed a retrospective study of patients with stage IC AGCT diagnosed at our hospital from January 1985 to September 2015. We analyzed descriptive statistics, and performed univariate and multivariate and Kaplan–Meier survival analyses...

Molecular features of giant-cell carcinoma of the lung: a case report and literature review

Molecular features of giant-cell carcinoma of the lung: a case report and literature review Xin Li,* Zihe Zhang,* Jinghao Liu, Dan Wang, Sen Wei, Jun Chen Department of Lung Cancer Surgery, Tianjin ... . Author contributions Xin Li and Jun Chen wrote the manuscript and analyzed all of the data. Xin Li, Zihe Zhang, Jinghao Liu, and Sen Wei provided medical care for the patients and collected the data. Dan

Coupling of ocean redox and animal evolution during the Ediacaran-Cambrian transition

The late Ediacaran to early Cambrian interval witnessed extraordinary radiations of metazoan life. The role of the physical environment in this biological revolution, such as changes to oxygen levels and nutrient availability, has been the focus of longstanding debate. Seemingly contradictory data from geochemical redox proxies help to fuel this controversy. As an essential...

Chiral phase transition of three flavor QCD with nonzero magnetic field using standard staggered fermions

Lattice simulations for (2+1)-flavor QCD with external magnetic field demon-strated that the quark mass is one of the important parameters responsible for the (inverse) magnetic catalysis. We discuss the dependences of chiral condensates and susceptibilities, the Polyakov loop on the magnetic field and quark mass in three degenerate flavor QCD. The lattice simulations are...

Kernel PCA feature extraction and the SVM classification algorithm for multiple-status, through-wall, human being detection

Ultra-wideband (UWB) radar with strong anti-jamming performance and high-range resolution can be used to separate multiple human targets in a complex environment. In recent years, through-wall human being detection with UWB radar has become relatively sophisticated. In this paper, the method of kernel principal component analysis (KPCA) feature extraction and the support vector...

Physiological mechanism of osmoregulatory adaptation in anguillid eels

In recent years, the production of eel larvae has dramatic declines due to reductions in spawning stocks, overfishing, growth habitat destruction and access reductions, and pollution. Therefore, it is particularly important and urgent for artificial production of glass eels. However, the technique of artificial hatching and rearing larvae is still immature, which has long been...

Streamlined ex vivo and in vivo genome editing in mouse embryos using recombinant adeno-associated viruses

National Institute of Health R01HD083311 and R21HD089566 (to J.A.R.-P.) and P01AI100263, R01NS076991, and P01HL131471 (to G.G.). Author information Author notes Yeonsoo Yoon and Dan Wang contributed ... in:Nature Research journals • PubMed • Google Scholar Search for Dan Wang in:Nature Research journals • PubMed • Google Scholar Search for Phillip W. L. Tai in:Nature Research journals • PubMed • Google

The association between vacA or cagA status and eradication outcome of Helicobacter pylori infection: A meta-analysis

involving vacA or cagA; and studies published neither in English nor Chinese; no data of eradication cases to vacA or cagA status. Data extraction Two authors (Dan Wang and Qiuping Li) extracted the data

Accurate Design of Low Backscattering Metasurface Using Iterative Fourier Transform Algorithm

An accurate method is proposed to design low-backscattering metasurfaces efficiently using an iterative Fourier transform algorithm, which avoids the large amount of time-consuming numerical simulations of complicated electromagnetic problems and provides satisfactory performance to reduce the backward scattering. As an example of the application, a broadband low-backscattering...

Isolation and characterization of Bacillus sp. GFP-2, a novel Bacillus strain with antimicrobial activities, from Whitespotted bamboo shark intestine

The abuse of antibiotics and following rapidly increasing of antibiotic-resistant pathogens is the serious threat to our society. Natural products from microorganism are regarded as the important substitution antimicrobial agents of antibiotics. We isolated a new strain, Bacillus sp. GFP-2, from the Chiloscyllium plagiosum (Whitespotted bamboo shark) intestine, which showed great...

Risk assessment of deoxynivalenol in high-risk area of China by human biomonitoring using an improved high throughput UPLC-MS/MS method

A risk assessment of deoxynivalenol (DON) was recently conducted for the residents in Henan province, China, where wheat as the staple food are highly consumed. A high-throughput sensitive UPLC-MS/MS method following 96-well μElution solid-phase extraction (SPE) were developed and validated for the determination of DON biomarkers in human urine. Isotope labelled internal standard...

Acoustic Log Prediction on the Basis of Kernel Extreme Learning Machine for Wells in GJH Survey, Erdos Basin

In petroleum exploration, the acoustic log (DT) is popularly used as an estimator to calculate formation porosity, to carry out petrophysical studies, or to participate in geological analysis and research (e.g., to map abnormal pore-fluid pressure). But sometime it does not exist in those old wells drilled 20 years ago, either because of data loss or because of just being not...

Acoustic Log Prediction on the Basis of Kernel Extreme Learning Machine for Wells in GJH Survey, Erdos Basin

In petroleum exploration, the acoustic log (DT) is popularly used as an estimator to calculate formation porosity, to carry out petrophysical studies, or to participate in geological analysis and research (e.g., to map abnormal pore-fluid pressure). But sometime it does not exist in those old wells drilled 20 years ago, either because of data loss or because of just being not...

The system capacity view of aging and longevity

XDB19020301 and XDA01010303 to J.D.J.H. COMPLIANCE WITH ETHICS GUIDELINES The authors Jing-Dong J. Han, Lei Hou, Na Sun, Chi Xu, Joseph McDermott and Dan Wang declare that they have no conflict of interests

A pH-gated conformational switch regulates the phosphatase activity of bifunctional HisKA-family histidine kinases

Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, 430071, ChinaYixiang Liu, Qiong Wu, Dan Wang, Conggang Li, Maili Liu & Ling JiangDepartment of Biochemistry ... , Chinese Academy of Sciences, Wuhan, 430071, ChinaShaojia Huang & Yangbo HuUniversity of Chinese Academy of Sciences, Beijing, 100049, ChinaShaojia Huang & Dan Wang AuthorsSearch for Yixiang Liu in:Nature

Colon Epithelial MicroRNA Network in Fatty Liver

holding NanoString options. Authors’ Contributions Wendy A. Henderson and Sarah K. Abey designed research. Sarah K. Abey, Natnael D. Kenea, Tatyana G. Vishnyakova, Dan Wang, Nicolaas H. Fourie, and Paule V ... . Joseph performed experiments and collected data. Paule V. Joseph, Sarah K. Abey, Dan Wang, and Tatyana G. Vishnyakova analyzed data. Paule V. Joseph, Dan Wang, Tatyana G. Vishnyakova, Nicolaas H. Fourie

The Time Lags Effects of Innovation Input on Output in National Innovation Systems: The Case of China

This paper investigates the time lags effects of innovation input on output in the national innovation systems (NIS). Firstly, we analyze the intrinsic properties of China’s NIS based on the conceptual framework and the causal loop diagram. Secondly, we construct a time lags distribution calculation model and employ the main innovation input indicators to measure the specific...