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High Energy Diets-Induced Metabolic and Prediabetic Painful Polyneuropathy in Rats

To establish the role of the metabolic state in the pathogenesis of polyneuropathy, an age- and sex-matched, longitudinal study in rats fed high-fat and high-sucrose diets (HFSD) or high-fat, high-sucrose and high-salt diets (HFSSD) relative to controls was performed. Time courses of body weight, systolic blood pressure, fasting plasma glucose (FPG), insulin, free fatty acids...

Highly Sensitive Plasmonic Detection of the Pancreatic Cancer Biomarker CA 19-9

Scholar Search for Long R. Jiao in:Nature Research journals • PubMed • Google Scholar Search for Fang Xie in:Nature Research journals • PubMed • Google Scholar Contributions Z.A.R.J. designed and ... idea and supervised the project. Competing Interests The authors declare that they have no competing interests. Corresponding author Correspondence to Fang Xie. Electronic supplementary material

Hydrogenations and electric field induced magnetic behaviors in armchair silicene nanoribbons

Using the first-principles calculations, we investigate the geometric, electronic and magnetic properties of armchair silicene nanoribbons with different edge hydrogenations. Our results show that the interesting magnetic behaviors such as the bipolar magnetic semiconductor can be found. Moreover, the addition of the transverse electric field can modulate the bipolar magnetic...

Imbalanced Frequencies of Th17 and Treg Cells in Acute Coronary Syndromes Are Mediated by IL-6-STAT3 Signaling

Aims Extensive evidence suggests inflammatory components participate in the pathogenic processes of acute coronary syndromes (ACS). In this study, we aimed to elucidate the role and mechanism underlying the imbalance of Th17 and Treg cell peripheral populations in the pathogenesis of ACS. Methods and Results Using a flow cytometric analysis, we observed a significantly increased...

In Vivo Molecular Imaging in Retinal Disease

Copyright © 2012 Fang Xie et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium

In vitro and in vivo apatinib inhibits vasculogenic mimicry in melanoma MUM-2B cells

: Zong-Jun-Lin Liu. Ling-Lin Yang, Qing-Lian Wen. Wen. Methodology: Rui-Lin Ding, Shao-Zhi Fu, Jing-Bo Wu, Ling-Lin Yang, Qing-Lian Wen. Project administration: Yu-Juan Zhou, Rui-Lin Ding, Fang Xie ... , Shao-Zhi Fu, Jing-Bo Wu, Supervision: Rui-Lin Ding, Fang Xie, Shao-Zhi Fu, Jing-Bo Wu, Ling-Lin Yang, Qing-Lian Writing ? original draft: Zong-Jun-Lin Liu, Rui-Lin Ding. Writing ? review & editing: Zong

Influence of fluvastatin on cardiac function and baroreflex sensitivity in diabetic rats

contribution Jing AI, Li-hua SUN, and Bao-feng YANG designed the research and supervised the project; Fang XIE and Chao SUN established the diabetic model; Jing-yuan LI and Guan-yi LU measured food and drink ... intake; Chao SUN, Xin CHEN, and Hui CHE performed the animal studies, including the biochemical indexes of blood and the recording of blood pressure, HR and BRS; Jing AI, Fang XIE, and Chao SUN analyzed

Mechanisms of GOLPH3 Associated with the Progression of Gastric Cancer: A Preliminary Study

Study Design To investigate the specific mechanisms by which Golgi phosphoprotein 3 (GOLPH3) affects the progression of gastric cancer and to explore its clinical significance. Methods Immunohistochemical analysis was used to evaluate the correlations between GOLPH3, phosphorylated mTOR (p-mTOR), phosphorylated Akt (p-Akt), phosphorylated p70S6 (p-p70S6), phosphorylated 4E-BP1 (p...

Mutational Landscapes of Sequential Prostate Metastases and Matched Patient Derived Xenografts during Enzalutamide Therapy

Developing patient derived models from individual tumors that capture the biological heterogeneity and mutation landscape in advanced prostate cancer is challenging, but essential for understanding tumor progression and delivery of personalized therapy in metastatic castrate resistant prostate cancer stage. To demonstrate the feasibility of developing patient derived xenograft...

Phenothiazine Derivative-Accelerated Microbial Extracellular Electron Transfer in Bioelectrochemical System

AffiliationsDepartment of Chemistry, University of Science & Technology of China, Hefei, 230026, ChinaXian-Wei Liu, Jie-Jie Chen, Yu-Xi Huang, Jia-Fang Xie, Wen-Wei Li, Guo-Ping Sheng, Yuan-Yuan Zhang, Rui Lu & Han-Qing ... • PubMed • Google ScholarSearch for Yu-Xi Huang in:Nature Research journals • PubMed • Google ScholarSearch for Jia-Fang Xie in:Nature Research journals • PubMed • Google ScholarSearch for Wen-Wei Li

Phylogenetic Meta-Analysis of the Functional Traits of Clonal Plants Foraging in Changing Environments

Foraging behavior, one of the adaptive strategies of clonal plants, has stimulated a tremendous amount of research. However, it is a matter of debate whether there is any general pattern in the foraging traits (functional traits related to foraging behavior) of clonal plants in response to diverse environments. We collected data from 97 published papers concerning the...

Primary Mechanism Study of Panax notoginseng Flower (Herb) on Myocardial Infarction in Rats

are solely responsible for the content of this paper. Conflicts of Interest The authors declare that there are no conflicts of interest. Authors’ Contributions Rui-Fang Xie and Zhi-Cheng Li equally

Pyridoxal phosphate synthases PdxS/PdxT are required for Actinobacillus pleuropneumoniae viability, stress tolerance and virulence

Pyridoxal 5’-phosphate (PLP) is an essential cofactor for numerous enzymes involved in a diversity of cellular processes in living organisms. Previous analysis of the Actinobacillus pleuropneumoniae S-8 genome sequence revealed the presence of pdxS and pdxT genes, which are implicated in deoxyxylulose 5-phosphate (DXP)-independent pathway of PLP biosynthesis; however, little is...

Real-time shear wave elastography (SWE) assessment of short- and long-term treatment outcome in Budd-Chiari syndrome: A pilot study

, Hua-Ning Shi. Methodology: Hong-Wei Wang, Yu-Kun Luo. Resources: Hong-Wei Wang, Hua-Ning Shi. Software: Hong-Wei Wang. 9 / 11 Supervision: Fang Xie. Validation: Fang Xie. Writing ? original draft

Relative Quantitation of Neuropeptides over a Thousand-fold Concentration Range

Neuropeptides are essential cell-to-cell signaling molecules that influence diverse regulatory and behavioral functions within biological systems. Differing in their amino acid sequences and post-translational modifications, hundreds of neuropeptides are produced via a series of enzymatic processing steps, and their levels vary with location, time, and physiological condition...

Replication of Putative Susceptibility Loci from Genome-Wide Association Studies Associated with Coronary Atherosclerosis in Chinese Han Population

Background Coronary atherosclerosis, the main cause of cardiovascular disease, is a progressive disease. Recent Genome Wide Association Studies (GWASs) discovered several novel loci associated with coronary artery disease (CAD) or its main complication myocardial infarction (MI). In this study, we investigated the associations between previously reported CAD- and MI-associated...

Role of (p)ppGpp in Viability and Biofilm Formation of Actinobacillus pleuropneumoniae S8

Actinobacillus pleuropneumoniae is a Gram-negative bacterium and the cause of porcine pleuropneumonia. When the bacterium encounters nutritional starvation, the relA-dependent (p)ppGpp-mediated stringent response is activated. The modified nucleotides guanosine 5’-diphosphate 3’-diphosphate (ppGpp) and guanosine 5’-triphosphate 3’-diphosphate (pppGpp) are known to be signaling...

Role of CYP2A13 in the bioactivation and lung tumorigenicity of the tobacco-specific lung procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: in vivo studies using a CYP2A13-humanized mouse model

The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), which is abundant in tobacco smoke, is a potent lung procarcinogen. The present study was aimed to prove that transgenic expression of human cytochrome P450 2A13 (CYP2A13), known to be selectively expressed in the respiratory tract and be the most efficient enzyme for NNK bioactivation in vitro...

Salvianolic acid B ameliorates depressive-like behaviors in chronic mild stress-treated mice: involvement of the neuroinflammatory pathway

-fang XIE and Shuo YAN isolated natural product; Qiu-ying ZHAO conducted the data analysis; Jin-qiang ZHANG, Xiao-hui WU wrote the first-draft manuscript and Zi-li YOU revised the manuscript ... Research, Development and Utilization of Chinese Medicine Resources, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaXiao-fang Xie & Cheng Peng AuthorsSearch for

Shizukaol D, a Dimeric Sesquiterpene Isolated from Chloranthus serratus, Represses the Growth of Human Liver Cancer Cells by Modulating Wnt Signalling Pathway

Natural products have become sources of developing new drugs for the treatment of cancer. To seek candidate compounds that inhibit the growth of liver cancer, components of Chloranthus serratus were tested. Here, we report that shizukaol D, a dimeric sesquiterpene from Chloranthus serratus, exerted a growth inhibition effect on liver cancer cells in a dose- and time-dependent...