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A hybrid splitting method for smoothing Tikhonov regularization problem

In this paper, a hybrid splitting method is proposed for solving a smoothing Tikhonov regularization problem. At each iteration, the proposed method solves three subproblems. First of all, two subproblems are solved in a parallel fashion, and the multiplier associated to these two block variables is updated in a rapid sequence. Then the third subproblem is solved in the sense of...

Clinicopathological significance and potential drug target of CDH1 in breast cancer: a meta-analysis and literature review

Clinicopathological significance and potential drug target of CDH1 in breast cancer: a meta-analysis and literature review Ruixue Huang,* Ping Ding,* Fei Yang*Department of Occupational and

Epigenetic modifications of interleukin-6 in synovial fibroblasts from osteoarthritis patients

Osteoarthritis (OA) is the most common degenerative disease of the synovial joint. The synovial membrane is responsible for the inflammatory reaction leading to the secretion of macrophage-derived pro-inflammatory cytokines, such as IL-6. Suppressing IL-6 over-expression in synovial fibroblasts (SF) is a promising method to prevent OA development and progression, in which the...

Establishment of a somatic embryo regeneration system and expression analysis of somatic embryogenesis-related genes in Chinese chestnut (Castanea mollissima Blume)

Somatic embryogenesis is a reliable and important tool, and the relevant genes controlling this process act as vital roles through the whole development of somatic embryos. However, regeneration via somatic embryogenesis in Chinese chestnut has been impeded and its molecular mechanism is not known. Therefore, firstly we described a protocol for somatic embryo initiation...

Substance P Promotes the Proliferation, but Inhibits Differentiation and Mineralization of Osteoblasts from Rats with Spinal Cord Injury via RANKL/OPG System

Spinal cord injury (SCI) causes a significant amount of bone loss, which results in osteoporosis (OP). The neuropeptide substance P (SP) and SP receptors may play important roles in the pathogenesis of OP after SCI. To identify the roles of SP in the bone marrow mesenchymal stem cell derived osteoblasts (BMSC-OB) in SCI rats, we investigated the expression of neurokinin-1...

A Comparison of Visual Assessment and Automated Digital Image Analysis of Ki67 Labeling Index in Breast Cancer

Background Ki67 labeling index (LI) is critical for treatment options and prognosis evaluation in breast cancer. Visual assessment (VA) is widely used to assess Ki67 LI, but has some limitations. In this study, we compared the consistency between VA and automated digital image analysis (DIA) of Ki67 LI in breast cancer, and to evaluate the application value of DIA in Ki67 LI...

Structure and properties of indium-doped ZnO films prepared by RF magnetron sputtering under different pressures

High conductive and transparent In-doped ZnO thin films were deposited on glass substrates by radio-frequency (RF) magnetron sputtering at 250 °C. Argon gas was used as the sputtering gas, and its pressure varies from 0.1 to 4.0 Pa. The influences of deposition pressure on the structural, electrical and optical properties of the films were investigated by means of X-ray...

The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor

• Google ScholarSearch for Weihua Zhou in:Nature Research journals • PubMed • Google ScholarSearch for Fei Yang in:Nature Research journals • PubMed • Google ScholarSearch for Guoan Chen in:Nature Research

Effects of cumulus cell removal time during in vitro fertilization on embryo quality and pregnancy outcomes: a prospective randomized sibling-oocyte study

Background To investigate whether cumulus cell removal after a 3 h co-incubation of gametes can affect the outcomes of in vitro fertilization. Methods A prospective randomized sibling-oocyte study was performed in which sibling oocytes obtained from each patient were randomly assigned to either a 3 h or 20 h group (cumulus cells removed at 3 h or 20 h after insemination...

Application of Minimum Reward Risk Model in Reservoir Generation Scheduling

Discrete time Markov decision process is studied and the minimum reward risk model is established for the reservoir long-term generation optimization. Different form the commonly used optimization criterion of best expected reward in reservoir scheduling, the probability that the expected generation of the whole period not exceeding the predete reward target to be smallest is...

Effective Task Scheduling and IP Mapping Algorithm for Heterogeneous NoC-Based MPSoC

; Accepted 17 June 2014; Published 10 July 2014 Academic Editor: Yuping Wang Copyright © 2014 Peng-Fei Yang and Quan Wang. This is an open access article distributed under the Creative Commons Attribution

Laser beam melting 3D printing of Ti6Al4V based porous structured dental implants: fabrication, biocompatibility analysis and photoelastic study

Sciences, Fudan University, Shanghai, 200032, ChinaDuan Ma AuthorsSearch for Fei Yang in:Nature Research journals • PubMed • Google ScholarSearch for Chen Chen in:Nature Research journals • PubMed • Google ... • Google ScholarSearch for YouCheng Yu in:Nature Research journals • PubMed • Google Scholar Contributions Ms. Fei Yang (M.Med), as the first author, carried out the conception of fabricating porous Ti6Al4V

An Interobserver Reproducibility Analysis of Ki67 Visual Assessment in Breast Cancer

Background Ki67 labeling index (LI) is used as a predictive marker and is associated with prognosis in breast cancer. However, standardised methodologies for measurement are lacking which has limited its application in clinical practice. In this study, we evaluated the interobserver concordance of visual assessment of Ki67 LI in breast cancer. Methods Ki67- immunostained slides...

Improved thermal design methodology for wind power converters

design. Fei YANG was born in China , in 1975 . He received the B .E. degree in Mechanical Manufacture and Technology from Southwest Jiaotong University in 1998 , and the M.E. degree in Engineering

OpenMS-Simulator: an open-source software for theoretical tandem mass spectrum prediction

Background Tandem mass spectrometry (MS/MS) acts as a key technique for peptide identification. The MS/MS-based peptide identification approaches can be categorized into two families, namely, de novo and database search. Both of the two types of approaches can benefit from an accurate prediction of theoretical spectrum. A theoretical spectrum consists of m/z and intensity of...

Orchid Species Richness along Elevational and Environmental Gradients in Yunnan, China

The family Orchidaceae is not only one of the most diverse families of flowering plants, but also one of the most endangered plant taxa. Therefore, understanding how its species richness varies along geographical and environmental gradients is essential for conservation efforts. However, such knowledge is rarely available, especially on a large scale. We used a database extracted...

mTORC1-Activated Monocytes Increase Tregs and Inhibit the Immune Response to Bacterial Infections

experiments. Lijun Fang, Wei Guo, Ting Xue, Fei Yang, Xiaoyan Zhang, Yazhi Yang, and Qian Wan performed experiments. Lijun Fang, Zhexin Shi, and Xulong Zhan analyzed the data. Lijun Fang and Shixuan Wang wrote

Positive Solutions for Third-Order Boundary-Value Problems with the Integral Boundary Conditions and Dependence on the First-Order Derivatives

2013; Accepted 9 June 2013 Academic Editor: Wei-Shih Du Copyright © 2013 Yanping Guo and Fei Yang. This is an open access article distributed under the Creative Commons Attribution License, which

Transcriptome Analysis and Gene Identification in the Pulmonary Artery of Broilers with Ascites Syndrome

Background Pulmonary arterial hypertension, also known as Ascites syndrome (AS), remains a clinically challenging disease with a large impact on both humans and broiler chickens. Pulmonary arterial remodeling presents a key step in the development of AS. The precise molecular mechanism of pulmonary artery remodeling regulating AS progression remains unclear. Methodology/Principal...

Influence of substrate on electricity generation of Shewanella loihica PV-4 in microbial fuel cells

Background The substrate, serving as carbon and energy source, is one of the major factors affecting the performance of microbial fuel cells (MFCs). We utilized BIOLOG system to rapidly screen substrates for electricigens, and further evaluated influence of these substrates on electricity generation of Shewanella loihica PV-4 in MFCs. Results Three of most favorable substrates...