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29 papers found.
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Regional perinatal mortality differences in the Netherlands; care is the question

Greta C Rijninks-van Driel 4 Gouke J Bonsel 3 Anita CJ Ravelli 2 0 Department of Obstetrics and Gynaecology, University Medical Center Groningen , Groningen , the Netherlands 1 Department of Clinical

Individual accumulation of heterogeneous risks explains perinatal inequalities within deprived neighbourhoods

Dutch’ figures on perinatal mortality and morbidity are poor compared to EU-standards. Considerable within-country differences have been reported too, with decreased perinatal health in deprived urban areas. We investigated associations between perinatal risk factors and adverse perinatal outcomes in 7,359 pregnant women participating in population-based prospective cohort study...

Management of miscarriage: a randomized controlled trial of expectant management versus surgical evacuation

BACKGROUND: In many countries, surgical uterine evacuation is the standard treatment for women with a miscarriage, but expectant management has been advocated as an alternative. The choice between the two options cannot be based on published evidence alone, because randomized clinical trials are scarce while generalizability of findings to patients with a strong preference for...

Maternal health-related quality of life after induction of labor or expectant monitoring in pregnancy complicated by intrauterine growth retardation beyond 36 weeks

Objective Pregnancies complicated by intrauterine growth retardation (IUGR) beyond 36 weeks of gestation are at increased risk of neonatal morbidity and mortality. Optimal treatment in IUGR at term is highly debated. Results from the multicenter DIGITAT (Disproportionate Intrauterine Growth Intervention Trial At Term) trial show that induction of labor and expectant monitoring...

Expectant management versus surgical evacuation in first trimester miscarriage: health-related quality of life in randomized and non-randomized patients

BACKGROUND: Expectant management, although less effective, is an alternative treatment option for surgical evacuation in women with a miscarriage. We assessed health-related quality of life (HRQL) differences over time between expectant and surgical management in women with a miscarriage. METHODS: Women with a miscarriage were randomized to either expectant (n = 64) or surgical...

Long term costs and effects of reducing the number of twin pregnancies in IVF by single embryo transfer: the TwinSing study

Mirjam MJ van Heesch 0 Gouke J Bonsel John CM Dumoulin Johannes LH Evers Mark AHBM van der Hoeven Johan L Severens Ramon HM Dykgraaf Fulco van der Veen Nino Tonch Willianne LDM Nelen Piet van

Additive or Sequential Nucleoside Analogue Therapy Compared with Continued Zidovudine Monotherapy in Human Immunodeficiency Virus-Infected Patients with Advanced Disease Does Not Prolong Survival: An Observational Study

To study the effect of sequential or additive use of zalcitabine or didanosine on survival in 308 human immunodeficiency virus-infected patients with advanced disease treated with zidovudine, an observational study using time-dependent Cox proportional hazards models was done. Changing to sequential or additive therapy was based on deterioration of a patient's health status, a...

362 Assessing performance of paediatric intensive care

Performance of a 10 bed paediatric intensive care unit (PICU) in a university children's hospital was assessed in a prospective cohort study of unselected, consequtive admissions. Collected data included primary clinical specialty, PRISM score derived mortality risk, administration of PICU-dependent therapy and vital status at discharge. Effectiveness of care was determined by...

Multiplex ligation-dependent probe amplification versus karyotyping in prenatal diagnosis: the M.A.K.E. study

Background In the past 30 years karyotyping was the gold standard for prenatal diagnosis of chromosomal aberrations in the fetus. Traditional karyotyping (TKT) has a high accuracy and reliability. However, it is labor intensive, the results take 14–21 days, the costs are high and unwanted findings such as abnormalities with unknown clinical relevance are not uncommon. These...