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Comparative Study on Non-Gaussian Characteristics of Wind Pressure for Rigid and Flexible Structures

This paper summarizes a comprehensive study for non-Gaussian properties of wind pressure. The field measurements are implemented on the structure surface of a rigid structure, while a large-span membrane structure is selected as the flexible structure wind pressure contrast group. The non-Gaussian characteristics of measured pressure data were analyzed and discussed through...

Comparative Study on Non-Gaussian Characteristics of Wind Pressure for Rigid and Flexible Structures

This paper summarizes a comprehensive study for non-Gaussian properties of wind pressure. The field measurements are implemented on the structure surface of a rigid structure, while a large-span membrane structure is selected as the flexible structure wind pressure contrast group. The non-Gaussian characteristics of measured pressure data were analyzed and discussed through...

Resting State fMRI: A Valuable Tool for Studying Cognitive Dysfunction in PD

Cognitive impairment is a common disabling symptom in PD. Unlike motor symptoms, the mechanism underlying cognitive dysfunction in Parkinson’s disease (PD) remains unclear and may involve multiple pathophysiological processes. Resting state functional magnetic resonance imaging (rs-fMRI) is a fast-developing research field, and its application in cognitive impairments in PD is...

The gene mutational discrepancies between primary and paired metastatic colorectal carcinoma detected by next-generation sequencing

PurposeTo better understand the gene mutational status and heterogeneity between primary and metastatic CRC (mCRC) using a sensitive sequencing method.MethodsThe mutational status of EGFR, KRAS, NRAS, PIK3CA, ERBB2, BRAF, KIT, and PDGFRA was analyzed in 65 patients, with 147 samples of primary and paired live or lung metastatic CRC, using next-generation sequencing (NGS...

Discovering Hierarchical Subgraphs of K-Core-Truss

Kongque Program (827/000065), and Beijing Institute of Technology Research Fund Program for Young Scholars. Dr. Rong-Hua Li is a corresponding author of this paper. Open Access This article is distributed

Study on Human-structure Dynamic Interaction in Civil Engineering

The research of human-structure dynamic interaction are reviewed. Firstly, the influence of the crowd load on structural dynamic characteristics is introduced and the advantages and disadvantages of different crowd load models are analyzed. Then, discussing the influence of structural vibration on the human-induced load, especially the influence of different stiffness structures...

Comprehensive analysis of competitive endogenous RNAs network associated with head and neck squamous cell carcinoma

Long non-coding RNAs (lncRNAs) can regulate gene expression directly or indirectly through interacting with microRNAs (miRNAs). However, the role of differentially expressed mRNAs, lncRNAs and miRNAs, and especially their related competitive endogenous RNAs (ceRNA) network in head and neck squamous cell carcinoma (HNSCC), is not fully comprehended. In this paper, the lncRNA...

Downregulation of microRNA-448 inhibits IL-1β-induced cartilage degradation in human chondrocytes via upregulation of matrilin-3

Hua Li 1 Nan Chen 1 Yongjun Shang 0 0 Department of Orthopedics, Dalian University Affiliated Xinhua Hospital , No. 156 Xinhua Street, Shahekou District, Dalian 116021, Liaoning Province , People's

The toxicological mechanisms and detoxification of depleted uranium exposure

Depleted uranium (DU) has been widely applied in industrial and military activities, and is often obtained from producing fuel for nuclear reactors. DU may be released into the environment, polluting air, soil, and water, and is considered to exert both radiological and chemical toxicity. In humans and animals, DU can induce multiple health effects, such as renal tubular necrosis...

Flubendazole inhibits glioma proliferation by G2/M cell cycle arrest and pro-apoptosis

Flubendazole, FDA-approved anthelmintic, has been widely used in treating testinal parasites. In the recent years, Flubendazole has been reported to exert anticancer activities. On the other hand, little was known about the effects of Flubendazole on gliomas. Here we demonstrated a novel effect of flubendazole on glioma cells. We found that Flubendazole inhibited cell...

Non-fluoroscopic percutaneous transcatheter closure of atrial septal defects in children under transesophageal echocardiographic guidance

BackgroundThis study sought to investigate the feasibility, safety and effectiveness of transcatheter closure of atrial septal defects (ASDs) under the guidance of transesophageal echocardiography (TEE) in children.MethodsWe reviewed the medical records of patients who underwent percutaneous ASD closure at our center from August 2016 to December 2017. For a total of 88 patients...

Fabrication of Microlens Array and Its Application: A Review

processing and robotics. Li‑Hua Li born in 1981, is current a research assistant at State Key Laboratory of Ultra-precision Machining Technology, the Hong Kong Polytechnic University, China. She earned her PhD

Extraction, purification, characterization and antioxidant activities of polysaccharides from Ramaria botrytis (Pers.) Ricken

Background Ramaria botrytis (Pers.) Ricken, a member of the family Clavariaceae, has been widely prescribed for anti-aging and improving immunity. To extract and purify the polysaccharides, the main constituent of the fruiting-body, from R. botrytis and explore antioxidant activities was great significant. Results Ramaria botrytis polysaccharides (RBP) was extracted with water at...

The impact of pharmaceutical interventions on the rational use of proton pump inhibitors in a Chinese hospital

The impact of pharmaceutical interventions on the rational use of proton pump inhibitors in a Chinese hospital Chuanwei Xin,1 Zhu Dong,2 Mengmeng Lin,1 Gong-Hua Li1 1Department of Pharmacy, Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang Province, 2Department of Pharmacy, the Fifth People’s Hospital of Yuhang District, Hangzhou, China Background: The...

Melatonin Reduces Inflammatory Injury through Inhibiting NF-κB Activation in Rats with Colitis

Proinflammatory mediators are important in the pathogenesis of IBD, which are regulated by activation of NF-κB. The aim of this study was to investigate whether melatonin reduces inflammatory injury and inhibits proinflammatory molecule and NF-κB in rats with colitis. Rat colitis model was established by TNBS enema. NF-κB p65, TNF-α, ICAM-1, and IκBα in colon tissue were examined...

Corneal Spherical Aberration and Corneal Asphericity after Small Incision Lenticule Extraction and Femtosecond Laser-Assisted LASIK

Purpose. To investigate corneal spherical aberration and corneal asphericity after small incision lenticule extraction (SMILE) and femtosecond laser-assisted laser in situ keratomileusis (FS-LASIK). Methods. This study enrolled 70 patients having SMILE and 64 subjects receiving FS-LASIK. The preoperative spherical equivalent (SE) was −5.83 ± 1.23 diopters (D) and −6.20 ± 1.52 D...

A survey of natural distribution of yellow tailflower mild mottle virus in south-western Australia reveals new indigenous and exotic hosts

Yellow tailflower mild mottle virus (YTMMV) was previously reported from two wild species of Anthocercis (family Solanaceae) in Western Australia. Here, a survey of 89 wild and cultivated plants from 14 species was done to determine if YTMMV occurred more widely in indigenous plants, and if it naturally infected cultivated exotic plants. The survey extended 1500 km, from Coral...

CXCL4 contributes to host defense against acute Pseudomonas aeruginosa lung infection

) for providing the Pseudomonas aeruginosa strain 8821. Author Contributions Conceptualization: Tong-Jun Lin, Zhongping Xie. Data curation: Lei Yue, Hua Li, Ting Yang. Formal analysis: Lei Guo, Xia

Asymmetric electric field screening in van der Waals heterostructures

, Geelong Waurn Ponds Campus, Victoria, 3216, AustraliaLu Hua Li & Qiran CaiInstitute for Chemical and Bioengineering, ETH Zürich, 8093, Zürich, SwitzerlandTian Tian & Chih-Jen ShihSchool of Mathematics and ... Physics, Queen’s University Belfast, Belfast, BT7 1NN, United KingdomElton J. G. Santos AuthorsSearch for Lu Hua Li in:Nature Research journals • PubMed • Google Scholar Search for Tian Tian in:Nature

Increasing the safety and efficacy of chimeric antigen receptor T cell therapy

interest are managed in accordance with University of Pennsylvania policy and oversight. Hua Li declares no conflicts of interest. This article does not contain any studies with human or animal subjects