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Search: authors:"Katsumi Tsukamoto"

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Evolution of the Deep-Sea Gulper Eel Mitochondrial Genomes: Large-Scale Gene Rearrangements Originated Within the Eels

Jun G. Inoue 0 Masaki Miya Katsumi Tsukamoto 0 Mutsumi Nishida 0 0 Ocean Research Institute, University of Tokyo , Tokyo , Japan; and Department of Zoology, Natural History Museum & Institute , Chiba

Primitive Duplicate Hox Clusters in the European Eel's Genome

The enigmatic life cycle and elongated body of the European eel (Anguilla anguilla L., 1758) have long motivated scientific enquiry. Recently, eel research has gained in urgency, as the population has dwindled to the point of critical endangerment. We have assembled a draft genome in order to facilitate advances in all provinces of eel biology. Here, we use the genome to...

Leptin directly stimulates aromatase activity in human luteinized granulosa cells

Leptin, the obese (ob) gene product, is secreted by adipocytes and regulates appetite through interaction with hypothalamic leptin receptors. Leptin may also have a stimulatory effect on reproductive function. Furthermore, leptin receptor mRNA is expressed in the ovary, suggesting a direct effect on its function. The present study examines the direct role of leptin on the...

Progesterone inhibition of functional leptin receptor mRNA expression in human endometrium

Leptin is secreted by adipocytes and regulates appetite through interaction with hypothalamic leptin receptors (OB-R). Leptin is involved in the stimulation of reproductive functions, and local expression of leptin and OB-R in the ovary, oocyte, embryo, and placenta might play a role in early development. The mRNA and protein of the long form leptin receptor (OB-RL) but not of...

Association of the CYP17 gene and CYP19 gene polymorphisms with risk of endometriosis in Japanese women

BACKGROUND: To investigate whether polymorphisms of CYP17 and CYP19 genes are associated with the risk of endometriosis, we analysed the frequency and distribution of a single nucleotide polymorphism at the 5′ untranslated region of the CYP17 gene, and a tetranucleotide (TTTA) tandem repeat polymorphism and a 3 bp insertion (I)/deletion (D) polymorphism in intron 4 of the CYP19...

Oestrogen receptor-alpha gene polymorphism is associated with endometriosis, adenomyosis and leiomyomata

Endometriosis, adenomyosis and leiomyomata develop in women of reproductive age and regress after menopause or ovariectomy, suggesting that they grow in an oestrogen-dependent fashion. We investigated whether polymorphism in the oestrogen receptor-alpha (ERα) gene is related to oestrogen-dependent benign uterine disease. A total of 203 women with regular menstrual cycles...