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Totipotency in the mouse

In mammals, the unicellular zygote starts the process of embryogenesis and differentiates into all types of somatic cells, including both fetal and extraembryonic lineages—in a highly organized manner to eventually give rise to an entire multicellular organism comprising more than 200 different tissue types. This feature is referred to as totipotency. Upon fertilization, oocyte...

Diversity Modification and Structure-Activity Relationships of Two Natural Products 1β-hydroxy Alantolactone and Ivangustin as Potent Cytotoxic Agents

He Shuai Dong Xin Guo Yu-Gong Wang Bei-Lei Lei Jun-Mian Tian Jin-Ming Gao OPEN Published: xx xx xxxx Sesquiterpene lactones (STLs) are a class of plant secondary metabolites widely found in nature

HSP90 recognizes the N-terminus of huntingtin involved in regulation of huntingtin aggregation by USP19

Huntington’s disease (HD) is caused by aberrant expansion of polyglutamine (polyQ) in the N-terminus of huntingtin (Htt). Our previous study has demonstrated that HSP90 is involved in the triage decision of Htt, but how HSP90 recognizes and regulates Htt remains elusive. We investigated the interaction between HSP90 and the N-terminal fragments of Htt (Htt-N), such as the N...

Circulating Betatrophin Levels and Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis

Objective The association between circulating betatrophin levels and gestational diabetes mellitus (GDM) is controversial. The aim of our study was to systematically review available literature linking betatrophin to GDM for a comprehensive understanding of the relationship between circulating betatrophin levels and GDM in human. Methods PubMed, The Cochrane Library, Medline and...

Clinicopathological Characteristics of Mucinous Breast Cancer: A Retrospective Analysis of a 10-Year Study

Background Mucinous breast carcinoma (MC) is a special type of breast cancer that presents with a large amount of extracellular mucin. MC comprises approximately 4% of all invasive breast cancers. This type of tumor has a better prognosis and higher incidence in peri- and post-menopausal patients. Pathologically, there are two main subtypes of MC: pure and mixed. In this study...

The N-terminal dimerization is required for TDP-43 splicing activity

TDP-43 is a nuclear factor that functions in promoting pre-mRNA splicing. Deletion of the N-terminal domain (NTD) and nuclear localization signal (NLS) (i.e., TDP-35) results in mislocalization to cytoplasm and formation of inclusions. However, how the NTD functions in TDP-43 activity and proteinopathy remains largely unknown. Here, we studied the structure and function of the...

A Segmentation Method for Lung Parenchyma Image Sequences Based on Superpixels and a Self-Generating Neural Forest

Background Lung parenchyma segmentation is often performed as an important pre-processing step in the computer-aided diagnosis of lung nodules based on CT image sequences. However, existing lung parenchyma image segmentation methods cannot fully segment all lung parenchyma images and have a slow processing speed, particularly for images in the top and bottom of the lung and the...

Serum selenium level and gestational diabetes mellitus: a systematic review and meta-analysis

Background The association between serum selenium level and gestational diabetes mellitus (GDM) is controversial. The aim of our study was to systematically review available literature linking selenium to GDM for a comprehensive understanding of the relationship between serum selenium level and GDM in human. Methods PubMed, The Cochrane Library and Medline were searched for...

The efficacy and safety of panitumumab in the treatment of patients with metastatic colorectal cancer: a meta-analysis from five randomized controlled trials

The efficacy and safety of panitumumab in the treatment of patients with metastatic colorectal cancer: a meta-analysis from five randomized controlled trials Ruo-feng Liang,1 Lei-lei Zheng2 1General ... ruo-feng liang 1 lei-lei Zheng 0 0 Department of Psychiatry, s econd a ffiliated h ospital of Zhejiang University school of Medicine , Hangzhou , People's Republic of China 1 g eneral Department

Increased microRNA-93-5p inhibits osteogenic differentiation by targeting bone morphogenetic protein-2

?token=clefscoqbpgxdid&;acc= GSE89587 (RAR) Author Contributions Data curation: Ying Zhang, Wei-Bin Ding, Lei-Lei Zhang, Hui-Chao Wang. Formal analysis: Ying Zhang. Funding acquisition: You-Wen Liu ... . Supervision: Ying Zhang. Writing ± original draft: Ying Zhang, Lei-Lei Zhang, Hui-Chao Wang, Ying-Jie Zhu, Yu-Na Chai, You-Wen Liu. Writing ± review & editing: Ying Zhang, Wei-Bin Ding, Lei-Lei Zhang, Hui

Relationship between body mass index and depressive symptoms: the “fat and jolly” hypothesis for the middle-aged and elderly in China

Li Zhuo Chen Li-li Zhang Lei-lei Guo 0 0 Department of Surgical Nursing, School of Nursing, Jinzhou Medical University , No.40, Section 3, Songpo Road, Linghe District, Jinzhou City, Liaoning Province ... authors are grateful to Kun Liu, Hong Li, Dan Li, Zhuo Chen, Li-li Zhang, and Lei-lei Guo. We thank the members of the CHARLS. Funding Collection of the CHARLS datasets used in the current study was

Elevated COX-2 Expression Promotes Angiogenesis Through EGFR/p38-MAPK/Sp1-Dependent Signalling in Pancreatic Cancer

Search for Meng Zhuo in:Nature Research journals • PubMed • Google Scholar Search for Lei-lei Wu in:Nature Research journals • PubMed • Google Scholar Search for Cuncun Yuan in:Nature Research journals

Three-dimensional broadband acoustic illusion cloak for sound-hard boundaries of curved geometry

Acoustic illusion cloaks that create illusion effects by changing the scattered wave have many potential applications in a variety of scenarios. However, the experimental realization of generating three-dimensional (3D) acoustic illusions under detection of broadband signals still remains challenging despite the paramount importance for practical applications. Here we report the...

Chemical Differentiation of Dendrobium officinale and Dendrobium devonianum by Using HPLC Fingerprints, HPLC-ESI-MS, and HPTLC Analyses

The stems of Dendrobium officinale Kimura et Migo (Dendrobii Officinalis Caulis) have a high medicinal value as a traditional Chinese medicine (TCM). Because of the limited supply, D. officinale is a high priced TCM, and therefore adulterants are commonly found in the herbal market. The dried stems of a closely related Dendrobium species, Dendrobium devonianum Paxt., are commonly...

Spliceosomal protein eftud2 mutation leads to p53-dependent apoptosis in zebrafish neural progenitors

Haploinsufficiency of EFTUD2 (Elongation Factor Tu GTP Binding Domain Containing 2) is linked to human mandibulofacial dysostosis, Guion-Almeida type (MFDGA), but the underlying cellular and molecular mechanisms remain to be addressed. We report here the isolation, cloning and functional analysis of the mutated eftud2 (snu114) in a novel neuronal mutant fn10a in zebrafish. This...

The pH-switchable agglomeration and dispersion behavior of fluorescent Ag nanoclusters and its applications in urea and glucose biosensing

Water-soluble fluorescent Ag nanoclusters (Ag NCs) with distinct pH-switchable agglomeration and spectral signal responses are prepared using a facile etching method. Increased and decreased pH cause the Ag NCs to switch between agglomeration and dispersion, accompanied by decreases in and recoveries of fluorescence intensity and absorbance. The pH switchable behavior of the Ag...

Acoustic one-way metasurfaces: Asymmetric Phase Modulation of Sound by Subwavelength Layer

• PubMed • Google ScholarSearch for Xin-ye Zou in:Nature Research journals • PubMed • Google ScholarSearch for Jing Yang in:Nature Research journals • PubMed • Google ScholarSearch for Lei-lei Yin in:Nature

ZP3 is Required for Germinal Vesicle Breakdown in Mouse Oocyte Meiosis

-Lei Gao, Chun-Xiang Zhou, Xiao-Lan Zhang, Peng Liu, Zhen Jin, Gang-Yi Zhu, Yang Ma, Jing Li, Zhi-Xia Yang & Dong Zhang AuthorsSearch for Lei-Lei Gao in:Nature Research journals • PubMed • Google

Serum starvation-induced cell cycle synchronization stimulated mouse rDNA transcription reactivation during somatic cell reprogramming into iPSCs

Zhao 0 Yanshuang Wu 0 Zhiyan Shan Guangyu Bai Zhendong Wang Jing Hu Li Liu Tong Li Jingling Shen Lei Lei 0 Equal contributors Department of Histology and Embryology, Harbin Medical University , Xuefu

A preliminary study of pamidronic acid downregulation of angiogenic factors IGF-1/PECAM-1 expression in circulating level in bone metastatic breast cancer patients

A preliminary study of pamidronic acid downregulation of angiogenic factors IGF-1/PECAM-1 expression in circulating level in bone metastatic breast cancer patients Zeng Wang,1,2 Lei Lei,2,3 Xin-jun