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Clinicopathological Characteristics of Mucinous Breast Cancer: A Retrospective Analysis of a 10-Year Study

Background Mucinous breast carcinoma (MC) is a special type of breast cancer that presents with a large amount of extracellular mucin. MC comprises approximately 4% of all invasive breast cancers. This type of tumor has a better prognosis and higher incidence in peri- and post-menopausal patients. Pathologically, there are two main subtypes of MC: pure and mixed. In this study...

Comparative Genomics Provide Insights into Evolution of Trichoderma Nutrition Style

Saprotrophy on plant biomass is a recently developed nutrition strategy for Trichoderma. However, the physiology and evolution of this new nutrition strategy is still elusive. We report the deep sequencing and analysis of the genome of Trichoderma longibrachiatum, an efficient cellulase producer. The 31.7-Mb genome, smallest among the sequenced Trichoderma species, encodes fewer...

Corrigendum: One Step Quantum Key Distribution Based on EPR Entanglement

Entanglement Jian Li Na Li Lei-Lei Li Tao Wang RepoRts

Coupled Resonance Enhanced Modulation for a Graphene-Loaded Metamaterial Absorber

A graphene-loaded metamaterial absorber is investigated in the mid-infrared region. The light-graphene interaction is greatly enhanced by virtue of the coupled resonance through a cross-shaped slot. The absorption peaks show a significant blueshift with increasing Fermi level, enabling a wide range of tunability for the absorber. A simple circuit model well explains and predicts...

Differential Gene Expression Profile in the Rat Caudal Vestibular Nucleus is Associated with Individual Differences in Motion Sickness Susceptibility

Objective To identify differentially expressed genes associated with motion sickness (MS) susceptibility in the rat caudal vestibular nucleus. Methods We identified MS susceptible (MSS) and insusceptible (inMSS) rats by quantifying rotation-induced MS symptoms: defecation and spontaneous locomotion activity. Microarray analysis was used to screen differentially expressed genes in...

Diversity Modification and Structure-Activity Relationships of Two Natural Products 1β-hydroxy Alantolactone and Ivangustin as Potent Cytotoxic Agents

He Shuai Dong Xin Guo Yu-Gong Wang Bei-Lei Lei Jun-Mian Tian Jin-Ming Gao OPEN Published: xx xx xxxx Sesquiterpene lactones (STLs) are a class of plant secondary metabolites widely found in nature

Effects of Huanglian-Jie-Du-Tang and Its Modified Formula on the Modulation of Amyloid-β Precursor Protein Processing in Alzheimer's Disease Models

Huanglian-Jie-Du-Tang (HLJDT) is a famous traditional Chinese herbal formula that has been widely used clinically to treat cerebral ischemia. Recently, we found that berberine, a major alkaloid compound in HLJDT, reduced amyloid-β (Aβ) accumulation in an Alzheimer’s disease (AD) mouse model. In this study, we compared the effects of HLJDT, four single component herbs of HLJDT...

Effects of dimethyl sulfoxide on asymmetric division and cytokinesis in mouse oocytes

Background Dimethyl sulfoxide (DMSO) is used extensively as a permeable cryoprotectant and is a common solvent utilized for several water-insoluble substances. DMSO has various biological and pharmacological activities; however, the effect of DMSO on mouse oocyte meiotic maturation remains unknown. Results In DMSO-treated oocytes, we observed abnormal MII oocytes that contained...

Elevated COX-2 Expression Promotes Angiogenesis Through EGFR/p38-MAPK/Sp1-Dependent Signalling in Pancreatic Cancer

Search for Meng Zhuo in:Nature Research journals • PubMed • Google Scholar Search for Lei-lei Wu in:Nature Research journals • PubMed • Google Scholar Search for Cuncun Yuan in:Nature Research journals

Enhancement of human ACAT1 gene expression to promote the macrophage-derived foam cell formation by dexamethasone

In macrophages, the accumulation of cholesteryl esters synthesized by the activated acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT1) results in the foam cell formation, a hallmark of early atherosclerotic lesions. In this study, with the treatment of a glucocorticoid hormone dexamethasone (Dex), lipid staining results clearly showed the large accumulation of lipid droplets...

Enhancing the light absorbance of polymer solar cells by introducing pulsed laser-deposited CuIn0.8Ga0.2Se2 nanoparticles

Evenly separated crystalline CuIn0.8Ga0.2Se2 (CIGS) nanoparticles are deposited on ITO-glass substrate by pulsed laser deposition. Such CIGS layers are introduced between conjugated polymer layers and ITO-glass substrates for enhancing light absorbance of polymer solar cells. The P3HT:PCBM absorbance between 300 and 650 nm is enhanced obviously due to the introduction of CIGS...

Event Detection and Multi-source Propagation for Online Social Network Management

) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Authors and Affiliations Lei-lei Shi1Lu Liu2Email authorYan Wu1Liang Jiang1Ayodeji Ayorinde31.School

Experimental Study on the Properties and Displacement Effects of Polymer Surfactant Solution

Based on the characteristics of oil reservoirs and the requirements of further enhancing oil recovery at high water cut stage of Pubei Oilfield, the displacement performance of polymer surfactant is evaluated. Reasonable injection parameters and oil displacement effects after water flooding are also researched. Compared with conventional polymer with intermediate molecular weight...

Experimental Study on the Properties and Displacement Effects of Polymer Surfactant Solution

Based on the characteristics of oil reservoirs and the requirements of further enhancing oil recovery at high water cut stage of Pubei Oilfield, the displacement performance of polymer surfactant is evaluated. Reasonable injection parameters and oil displacement effects after water flooding are also researched. Compared with conventional polymer with intermediate molecular weight...

HSP90 recognizes the N-terminus of huntingtin involved in regulation of huntingtin aggregation by USP19

Huntington’s disease (HD) is caused by aberrant expansion of polyglutamine (polyQ) in the N-terminus of huntingtin (Htt). Our previous study has demonstrated that HSP90 is involved in the triage decision of Htt, but how HSP90 recognizes and regulates Htt remains elusive. We investigated the interaction between HSP90 and the N-terminal fragments of Htt (Htt-N), such as the N...

Heterologous expression of human costimulatory molecule B7-2 and construction of B7-2 immobilized polyhydroxyalkanoate nanoparticles for use as an immune activation agent

Ming-Chuan Li 0 Qian-Qian Liu 0 Xiao-Yun Lu Ya-Li Zhang Lei-Lei Wang 0 Equal contributors Department of Biological Science and Bioengineering, Key Laboratory of Biomedical Information Engineering of

Hypercholesterolemic Myocardium Is Vulnerable to Ischemia-Reperfusion Injury and Refractory to Sevoflurane-Induced Protection

Recent studies have demonstrated that volatile anesthetic postconditioning confers myocardial protection against ischemia-reperfusion (IR) injury through activation of the reperfusion injury salvage kinase (RISK) pathway. As RISK has been shown to be impaired in hypercholesterolemia. Therefore, we investigate whether anesthetic-induced cardiac protection was maintained in...