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140 papers found.
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Gambogenic acid inhibits fibroblast growth factor receptor signaling pathway in erlotinib-resistant non-small-cell lung cancer and suppresses patient-derived xenograft growth

, Wenwei Fu, Hongsheng Tan, Li Zhang, Yuanzhi Lao & Hongxi XuEngineering Research Center of Shanghai Colleges for TCM New Drug Discovery, 201203, Shanghai, P.R. ChinaLinfeng Xu, Xiaoxiao Meng, Wenwei Fu ... , Hongsheng Tan, Li Zhang, Yuanzhi Lao & Hongxi XuShanghai Chempartner Co., Ltd, 201203, Shanghai, P.R. ChinaLinfeng Xu, Jianan Qian, Shiwei Tu & Xueting LiKey Lab in Healthy Science and Technology, Division of

Vitamin A and E Nutritional Status in Relation to Leptin, Adiponectin, IGF-I and IGF-II in Early Life - a Birth Cohort Study

The metabolic health effects of vitamin A and E nutritional status in early life are largely unknown. We assessed whether vitamin A and vitamin E nutritional status may affect circulating leptin, adiponectin, insulin-like growth factor (IGF)-I and IGF-II levels in early life in humans. In a singleton birth cohort (n = 248), vitamin A and E nutritional status in fetuses/newborns...

High-fat diet and chronic stress aggravate adrenal function abnormality induced by prenatal caffeine exposure in male offspring rats

Lian Liu Chunyan Zhu Youyin Lei Li Zhang Cai Si Hui Wang OPEN Published: xx xx xxxx We previously demonstrated thatprenatal caffeine exposure (PCE) suppressed fetal adrenal steroidogenesis and resulted

Chronic Intermittent Hypobaric Hypoxia Improves Cardiac Function through Inhibition of Endoplasmic Reticulum Stress

We investigated the role of endoplasmic reticulum stress (ERS) in chronic intermittent hypobaric hypoxia (CIHH)-induced cardiac protection. Adult male Sprague-Dawley rats were exposed to CIHH treatment simulating 5000 m altitude for 28 days, 6 hours per day. The heart was isolated and perfused with Langendorff apparatus and subjected to 30-min ischemia followed by 60-min...

One-pot synthesis of class II lanthipeptide bovicin HJ50 via an engineered lanthipeptide synthetase

Lanthipeptides are a large class of bacteria-produced, ribosomally-synthesized and post-translationally modified peptides. They are recognized as peptide antibiotics because most of them exhibit potent antimicrobial activities against Gram-positive bacteria especially those that are phylogenetically related to producers. Maturation of class II lanthipeptide like bovicin HJ50...

Biomimetic supercontainers for size-selective electrochemical sensing of molecular ions

New ionophores are essential for advancing the art of selective ion sensing. Metal-organic supercontainers (MOSCs), a new family of biomimetic coordination capsules designed using sulfonylcalix[4]arenes as container precursors, are known for their tunable molecular recognition capabilities towards an array of guests. Herein, we demonstrate the use of MOSCs as a new class of size...

Ethyl cellulose nanodispersions as stabilizers for oil in water Pickering emulsions

• Google Scholar Search for Li Zhang in:Nature Research journals • PubMed • Google Scholar Search for Xingzhong Zhang in:Nature Research journals • PubMed • Google Scholar Search for Ya Zhu in:Nature

Mapping surface-modified titania nanoparticles with implications for activity and facet control

Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai, 200433, People’s Republic of ChinaYichen Hu, Yingyi Fu, Li Zhang & Heyong HeGraduate Institute of Applied ... • PubMed • Google Scholar Search for Ivo F. Teixeira in:Nature Research journals • PubMed • Google Scholar Search for Li Zhang in:Nature Research journals • PubMed • Google Scholar Search for Heyong He

A smart sealed nucleic acid biosensor based on endogenous reference gene detection to screen and identify mammals on site

The identification of meat adulteration is a hotspot for food research worldwide. In this paper, a smart and sealed biosensor that combines loop-mediated isothermal amplification (LAMP) with a lateral flow device (LFD) was developed, resulting in the universal mammalian assessment on site. First, the highly specific chromosomal Glucagon gene (Gcg) was chosen as the endogenous...

Molecular epidemiology of acute hemorrhagic conjunctivitis caused by coxsackie A type 24 variant in China, 2004–2014

To understand control interventions, the molecular epidemiology of acute hemorrhagic conjunctivitis (AHC) was investigated from 2004 to 2014.A total of 613,485 AHC cases (annualized cases 55,771) with two deaths were included. Our findings showed that AHC was reported in all provinces, predominantly in Southern and Eastern China. The incidence rates were highest in 2007 (5.65/100...

Management of glycemic variation in diabetic patients receiving parenteral nutrition by continuous subcutaneous insulin infusion (CSII) therapy

Technology Support Program of Jiangsu Province (No. BL2014010) and a Project funded by the China Postdoctoral Science Foundation (No. 2015M581829). Author information Author notes Feng-fei Li, Wen-li Zhang ... Scholar Search for Wen-li Zhang in:Nature Research journals • PubMed • Google Scholar Search for Bing-li Liu in:Nature Research journals • PubMed • Google Scholar Search for Dan-feng Zhang in:Nature

CarcinoPred-EL: Novel models for predicting the carcinogenicity of chemicals using molecular fingerprints and ensemble learning methods

Molecules of Liaoning and Research Center for Computer Simulating and Information Processing of Bio-macromolecules of Liaoning Province. Author information Author notes Li Zhang and Haixin Ai contributed ... University, Shenyang, 110036, ChinaQi Zhao AuthorsSearch for Li Zhang in:Nature Research journals • PubMed • Google Scholar Search for Haixin Ai in:Nature Research journals • PubMed • Google Scholar Search

Publisher Correction: Simultaneous overactivation of Wnt/β-catenin and TGFβ signalling by miR-128-3p confers chemoresistance-associated metastasis in NSCLC

Song, Yukai He, Li Zhang & 1 In the original version of this Article, the affiliation details for Yan Huang and Li Zhang were incorrectly given as 'Department of Medical Oncology, Sun Yat-Sen University

Fucoxanthin provides neuroprotection in models of traumatic brain injury via the Nrf2-ARE and Nrf2-autophagy pathways

China (No. 81672503 and 81401026) and the Key Medical Subjects of Jiangsu Province (no. X4200722). Author Contributions Li Zhang, Handong Wang and Youwu Fan participated in the design of the study. Li ... Zhang, Yongyue Gao and Yujie Wang carried out the in vivo biological experiments. Li Zhang, Xiang Li and Ke Ding performed the experiments in vitro. Li Zhang, Zhigang Hu and Xiaoliang Wang provided

Minimising efficiency roll-off in high-brightness perovskite light-emitting diodes

, Nana Wang, Yu Cao, Yanfeng Miao, Mengmeng Xu, Qiang Guo, Li Zhang, Chang Yi, Jianpu Wang & Wei HuangSchool of Physical Science and Information Technology, Liaocheng University, Liaocheng, 252059 ... • Google Scholar Search for Li Zhang in:Nature Research journals • PubMed • Google Scholar Search for Chang Yi in:Nature Research journals • PubMed • Google Scholar Search for Feng Gao in:Nature Research

Downregulation of Interferon-β and Inhibition of TLR3 Expression are associated with Fatal Outcome of Severe Fever with Thrombocytopenia Syndrome

Severe Fever with Thrombocytopenia Syndrome (SFTS) is an emerging infectious disease with high mortality and increasing prevalence in the East Asia. Though the etiological agent has been identified as a novel Bunyavirus, cellular mechanisms of viral pathogenesis and host immune response to SFTS virus infection remain unknown. A comprehensive study was conducted on a cohort of 70...

Cytosolic co-delivery of miRNA-34a and docetaxel with core-shell nanocarriers via caveolae-mediated pathway for the treatment of metastatic breast cancer

Co-delivery of microRNAs and chemotherapeutic drugs into tumor cells is an attractive strategy for synergetic breast cancer therapy due to their complementary mechanisms. In this work, a core-shell nanocarrier coated by cationic albumin was developed to simultaneously deliver miRNA-34a and docetaxel (DTX) into breast cancer cells for improved therapeutic effect. The co-delivery...

RIPK3 interactions with MLKL and CaMKII mediate oligodendrocytes death in the developing brain

, Li Zhang, Q Richard Lu & Dezhi MuKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu 610041, ChinaYi Qu, Jun Tang, Huiqing ... Wang, Shiping Li, Fengyan Zhao, Li Zhang, Q Richard Lu & Dezhi MuDepartment of Pediatrics, Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center

Prognostic value of high-expression of miR-17-92 cluster in various tumors: evidence from a meta-analysis

criteria, we extracted the relevant information from each eligible publication. If disagreements were noticed, we are clearly open to discussion by each other (Kaiping Zhang and Li Zhang), or reviewed by a

Temperature response of soil carbon decomposition depends strongly on forest management practice and soil layer on the eastern Tibetan Plateau

How forest management practice impacts the temperature response of soil carbon decomposition remains unclear in Tibetan boreal forests. Here, an experiment was conducted to compare soil carbon decomposition of two layers (organic and mineral) in three Tibetan forests (natural forest, NF; secondary forest, SF; spruce plantation, PF). Soils were incubated at two temperatures (10 °C...