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Fundamental-Solution-Based Hybrid Element Model for Nonlinear Heat Conduction Problems with Temperature-Dependent Material Properties

The boundary-type hybrid finite element formulation coupling the Kirchhoff transformation is proposed for the two-dimensional nonlinear heat conduction problems in solids with or without circular holes, and the thermal conductivity of material is assumed to be in terms of temperature change. The Kirchhoff transformation is firstly used to convert the nonlinear partial...

Increased Na+/Ca2+ Exchanger Activity Promotes Resistance to Excitotoxicity in Cortical Neurons of the Ground Squirrel (a Hibernator)

Ground squirrel, a hibernating mammalian species, is more resistant to ischemic brain stress than rat. Gaining insight into the adaptive mechanisms of ground squirrels may help us design treatment strategies to reduce brain damage in patients suffering ischemic stroke. To understand the anti-stress mechanisms in ground squirrel neurons, we studied glutamate toxicity in primary...

Enhanced Biological Behavior of In Vitro Human Gingival Fibroblasts on Cold Plasma-Treated Zirconia

Objective To evaluate whether atmospheric-pressure dielectric-barrier-discharge plasma treatment of zirconia enhances its biocompatibility with human gingival fibroblasts. Materials and Methods The zirconia disks were divided into four groups and treated using helium atmospheric-pressure dielectric-barrier-discharge plasmas for 30, 60 or 90 s or left untreated. The surface...

Lane Changing Trajectory Planning and Tracking Controller Design for Intelligent Vehicle Running on Curved Road

To enhance the active safety and realize the autonomy of intelligent vehicle on highway curved road, a lane changing trajectory is planned and tracked for lane changing maneuver on curved road. The kinematics model of the intelligent vehicle with nonholonomic constraint feature and the tracking error model are established firstly. The longitudinal and lateral coupling and the...

Lnc2Cancer: a manually curated database of experimentally supported lncRNAs associated with various human cancers

Lnc2Cancer (http://www.bio-bigdata.net/lnc2cancer) is a manually curated database of cancer-associated long non-coding RNAs (lncRNAs) with experimental support that aims to provide a high-quality and integrated resource for exploring lncRNA deregulation in various human cancers. LncRNAs represent a large category of functional RNA molecules that play a significant role in human...

Simultaneous Quantitative and Qualitative Analysis of Flavonoids from Ultraviolet-B Radiation in Leaves and Roots of Scutellaria baicalensis Georgi Using LC-UV-ESI-Q/TOF/MS

Fang, Xiao Liu, and Ming Yue Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, The College of Life Sciences, Northwest University, No. 229 Taibai North Road

Simultaneous Quantitative and Qualitative Analysis of Flavonoids from Ultraviolet-B Radiation in Leaves and Roots of Scutellaria baicalensis Georgi Using LC-UV-ESI-Q/TOF/MS

Fang, Xiao Liu, and Ming Yue Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, The College of Life Sciences, Northwest University, No. 229 Taibai North Road

Simultaneous Quantitative and Qualitative Analysis of Flavonoids from Ultraviolet-B Radiation in Leaves and Roots of Scutellaria baicalensis Georgi Using LC-UV-ESI-Q/TOF/MS

Fang, Xiao Liu, and Ming Yue Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, The College of Life Sciences, Northwest University, No. 229 Taibai North Road

Rad4 Mainly Functions in Chk1-Mediated DNA Damage Checkpoint Pathway as a Scaffold Protein in the Fission Yeast Schizosaccharomyces pombe

Rad4/Cut5 is a scaffold protein in the Chk1-mediated DNA damage checkpoint in S. pombe. However, whether it contains a robust ATR-activation domain (AAD) required for checkpoint signaling like its orthologs TopBP1 in humans and Dpb11 in budding yeast has been incompletely clear. To identify the putative AAD in Rad4, we carried out an extensive genetic screen looking for novel...

MAL62 overexpression and NTH1 deletion enhance the freezing tolerance and fermentation capacity of the baker’s yeast in lean dough

Background Trehalose is related to several types of stress responses, especially freezing response in baker’s yeast (Saccharomyces cerevisiae). It is desirable to manipulate trehalose-related genes to create yeast strains that better tolerate freezing-thaw stress with improved fermentation capacity, which are in high demand in the baking industry. Results The strain...

FOXP3 promotes tumor growth and metastasis by activating Wnt/β-catenin signaling pathway and EMT in non-small cell lung cancer

The role of cancer cell FOXP3 in tumorigenesis is conflicting. We aimed to study FOXP3 expression and regulation, function and clinical implication in human non-small cell lung cancer (NSCLC). One hundred and six patients with histologically-confirmed NSCLC who underwent surgery were recruited for the study. Tumor samples and NSCLC cell lines were used to examine FOXP3 and its...

Patterns of taxonomic, phylogenetic diversity during a long-term succession of forest on the Loess Plateau, China: insights into assembly process

, Northwest University, Taibai north Rd.229, Xi’an City, Shaanxi Province, ChinaYongfu Chai, Ming Yue, Xiao Liu, Yaoxin Guo, Mao Wang, Jinshi Xu, Chenguang Zhang, Yu Chen & Lixia ZhangPlant Ecology Department ... , University of Tuebingen, Auf der Morgenstelle 3, 72076 Tuebingen, GermanyRuichang Zhang AuthorsSearch for Yongfu Chai in:Nature Research journals • PubMed • Google ScholarSearch for Ming Yue in:Nature Research

LincSNP 2.0: an updated database for linking disease-associated SNPs to human long non-coding RNAs and their TFBSs

We describe LincSNP 2.0 (http://bioinfo.hrbmu.edu.cn/LincSNP), an updated database that is used specifically to store and annotate disease-associated single nucleotide polymorphisms (SNPs) in human long non-coding RNAs (lncRNAs) and their transcription factor binding sites (TFBSs). In LincSNP 2.0, we have updated the database with more data and several new features, including (i...

The Invasion of Coastal Areas in South China by Ipomoea cairica May Be Accelerated by the Ecotype Being More Locally Adapted to Salt Stress

Local adaptation and phenotypic plasticity are two alternative mechanisms used by invasive plants for range expansion. We conducted a series of experiments to investigate the role of these mechanisms in the recent expansion of the invasive Ipomoea cairica from non-saline to salt-stressed coastal habitats. A comparison of the plant’s photosynthetic traits and construction costs...

Evaluation of the mechanisms of intron loss and gain in the social amoebae Dictyostelium

Background Spliceosomal introns are a common feature of eukaryotic genomes. To approach a comprehensive understanding of intron evolution on Earth, studies should look beyond repeatedly studied groups such as animals, plants, and fungi. The slime mold Dictyostelium belongs to a supergroup of eukaryotes not covered in previous studies. Results We found 441 precise intron losses in...

Grazoprevir and Elbasvir in Patients with Genotype 1 Hepatitis C Virus Infection: A Comprehensive Efficacy and Safety Analysis

conflict of interests. Authors’ Contributions Rongbin Yu and Peng Huang participated in the design of the study. Yinan Yao, Ming Yue, Mei Liu, and Feng Zang took charge of data collection and quality control ... . Yinan Yao, Jie Wang, and Hongbo Chen performed the statistical analysis. Jun Li and Yun Zhang contributed materials and analysis tools. Yinan Yao, Ming Yue, and Peng Huang wrote the paper. All authors

Grazoprevir and Elbasvir in Patients with Genotype 1 Hepatitis C Virus Infection: A Comprehensive Efficacy and Safety Analysis

conflict of interests. Authors’ Contributions Rongbin Yu and Peng Huang participated in the design of the study. Yinan Yao, Ming Yue, Mei Liu, and Feng Zang took charge of data collection and quality control ... . Yinan Yao, Jie Wang, and Hongbo Chen performed the statistical analysis. Jun Li and Yun Zhang contributed materials and analysis tools. Yinan Yao, Ming Yue, and Peng Huang wrote the paper. All authors

Efficacy differences of electroacupuncture with single acupoint or matching acupoints for chemotherapy-induced nausea and vomiting: study protocol for a randomized controlled trial

Previous studies have shown that acupuncture is beneficial for the alleviation of chemotherapy-induced nausea and vomiting. However, there is a lack of clinical evidence concerning the effects of acupoint-matching on chemotherapy-induced nausea and vomiting. This is a parallel randomized controlled trial to evaluate the occurrence of nausea and vomiting after chemotherapy (the...

Genetic variants in interferon-λ 4 influences HCV clearance in Chinese Han population

Recent many studies indicated a novel dinucleotide variant in ss469415590 (TT vs. ΔG) of interferon-λ 4 (IFNL4) gene strongly associated with hepatitis C virus clearance. To evaluate the impact and clinical usefulness of IFNL4 ss469415590 genotype on predicting both spontaneous HCV clearance and response to therapy in Chinese population, we genotyped 795 chronic HCV carriers, 460...

RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia

• PubMed • Google Scholar Search for Yuan Li in:Nature Research journals • PubMed • Google Scholar Search for Adam Cloe in:Nature Research journals • PubMed • Google Scholar Search for Ming Yue in:Nature ... information Author notes These authors contributed equally: Li Chen, Yuan Li. AffiliationsDepartment of Pathology, University of Chicago, Chicago, IL, 60637, USAJason X. Cheng, Li Chen, Yuan Li, Adam Cloe, Ming