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Cordycepin induces apoptosis in human pancreatic cancer cells via the mitochondrial-mediated intrinsic pathway and suppresses tumor growth in vivo

Cordycepin induces apoptosis in human pancreatic cancer cells via the mitochondrial-mediated intrinsic pathway and suppresses tumor growth in vivo Yu Zhang,1,2,* Xiao Xi Zhang,3,* Rui Yan Yuan,1,4

Potential of mean force between oppositely charged nanoparticles: A comprehensive comparison between Poisson–Boltzmann theory and Monte Carlo simulations

Ion-mediated interactions between like-charged polyelectrolytes have been paid much attention, and the Poisson–Boltzmann (PB) theory has been shown to fail in qualitatively predicting multivalent ion-mediated like-charge attraction. However, inadequate attention has been paid to the ion-mediated interactions between oppositely charged polyelectrolytes. In this work, the...

Impact of Etoposide on BRCA1 Expression in Various Breast Cancer Cell Lines

the topic and contributed to manuscript editing. SS supervised the research. All authors read and approved the final manuscript. Compliance with Ethical Standards Conflict of Interest Xi Zhang, Simone

Root exudate metabolites drive plant-soil feedbacks on growth and defense by shaping the rhizosphere microbiota

, SwitzerlandLingfei Hu, Christelle A. M. Robert, Xi Zhang, Meng Ye, Beibei Li, Daniele Manzo, Klaus Schlaeppi & Matthias ErbDivision of Agroecology and Environment, Agroscope, 8046, Zürich, SwitzerlandSelma Cadot ... journals • PubMed • Google Scholar Search for Xi Zhang in:Nature Research journals • PubMed • Google Scholar Search for Meng Ye in:Nature Research journals • PubMed • Google Scholar Search for Beibei Li

Efficient path routing strategy for flows with multiple priorities on scale-free networks

In real networks, traffic flows are different in amount as well as their priorities. However, the latter priority has rarely been examined in routing strategy studies. In this paper, a novel routing algorithm, which is based on the efficient path routing strategy (EP), is proposed to overcome network congestion problem caused by large amount of traffic flows with different...

Transcriptional profiling of PBMCs unravels B cell mediated immunopathogenic imprints of HCV vasculitis

Contributions Conceptualization: Shyamasundaran Kottilil. Data curation: Shyamasundaran Kottilil. Formal analysis: Benjamin Emmanuel, Shyamasundaran Kottilil. Investigation: Cheol-Woo Kim, Alison Murphy, Xi ... Zhang, Michael Sneller, Shyamasundaran Kottilil. Methodology: Shyamasundaran Kottilil. Supervision: Shyamasundaran Kottilil. Validation: Shyamasundaran Kottilil. Visualization: Shyamasundaran

New Insights into PI3K Inhibitor Design using X-ray Structures of PI3Kα Complexed with a Potent Lead Compound

Phosphatidylinositol 3-kinase α is an attractive target to potentially treat a range of cancers. Herein, we described the evolution of a reported PI3K inhibitor into a moderate PI3Kα inhibitor with a low molecular weight. We used X-ray crystallography to describe the accurate binding mode of the compound YXY-4F. A comparison of the p110α–YXY-4F and apo p110α complexes showed that...

Hydrogen-bond potential for ice VIII-X phase transition

, ChinaXi ZhangSchool of Physics and Astronomy, the University of Manchester, Manchester, M13 9PL, UKShun Chen & Jichen Li AuthorsSearch for Xi Zhang in:Nature Research journals • PubMed • Google ... interests The authors declare no competing financial interests. Corresponding authors Correspondence to Xi Zhang or Jichen Li. Supplementary information PDF files1.Supplementary Information Rights

Decreased Triple Network Connectivity in Patients with Recent Onset Post-Traumatic Stress Disorder after a Single Prolonged Trauma Exposure

Lihong Li Xi Zhang Hongbing Lu Hong Yin OPEN Published: xx xx xxxx The triple network model provides a common framework for understanding affective and neurocognitive dysfunctions across multiple

Guided bone regeneration with asymmetric collagen-chitosan membranes containing aspirin-loaded chitosan nanoparticles

Guided bone regeneration with asymmetric collagen-chitosan membranes containing aspirin-loaded chitosan nanoparticles Jiayu Zhang,1 Shiqing Ma,1 Zihao Liu,1 Hongjuan Geng,1 Xin Lu,1 Xi Zhang,1

Numerical investigation on the effect of labyrinth seal configuration on leakage

Labyrinth seals have been widely used in rotating machines. In this paper, labyrinth seals with rectangular tooth used in seawater pump with axial flow distribution were studied. The effects of structure parameters of labyrinth seals on sealing performance were numerically studied by the commercial computational fluid dynamics (CFD) software. The sealing length was considered as...

Competition between High-Speed Rail and Airline Based on Game Theory

The coexistence of high-speed rail (HSR) and airline in a busy transportation corridor generates competition between the two transportation modes. An unfair competition between HSR and airline not only reduces both revenues, but also triggers a series of social problems. Based on generalized costs, this paper proposes combining an improved gray prediction model, modified gravity...

Effects of NRG1 Polymorphisms on Hirschsprung’s Disease Susceptibility: A Meta-analysis

Substantial resources have been devoted to evaluate the relationship between NRG1 variants rs7835688 and rs16879552 and Hirschsprung’s Disease (HSCR) but no consistency exists. This meta-analysis aimed to assess the association between the two SNPs and HSCR. PubMed, EMBASE, and Chinese Biological Medicine databases were searched for studies potentially eligible up to March, 2017...

Effective and Fast Near Duplicate Detection via Signature-Based Compression Metrics

Electronic and Information Engineering in Dongguan, UESTC, Dongguan, China Received 22 May 2016; Accepted 8 September 2016 Academic Editor: Yuqiang Wu Copyright © 2016 Xi Zhang et al. This is an open

Acute WT1-positive promyelocytic leukemia with hypogranular variant morphology, bcr-3 isoform of PML-RARα and Flt3-ITD mutation: a rare case report

13452993609 Fax. +86 023 68763198 E-mail: The authors Xi Zhang and Cheng Yang contributed equally to this work Conflict of interest: The authors declare that there was no conflict of interest  This

Tax Arrangement and Regional Industrial Restructuring: Evidence from Panel Data in China

Regional industrial restructuring has been one of the major items in the transformation of economic development mode. An exploration was made into the influence of tax arrangement on the regional industrial structure by setting up a panel data econometric model based on the evaluation and analysis of the regional industrial structure in China. It was shown that tax arrangement...

Optimal donor for severe aplastic anemia patient requiring allogeneic hematopoietic stem cell transplantation: A large-sample study from China

HLA-haploidentical hematopoietic stem cell transplantation (HSCT) may be an option for severe aplastic anemia (SAA) patients. However, to date, no large-sample studies have been performed to determine which types of SAA patients are suitable for HLA-haploidentical HSCT. We retrospectively studied 189 consecutive patients with SAA who underwent HLA-identical or HLA-haploidentical...

Minimal invasive puncture and drainage versus endoscopic surgery for spontaneous intracerebral hemorrhage in basal ganglia

Minimal invasive puncture and drainage versus endoscopic surgery for spontaneous intracerebral hemorrhage in basal ganglia Zhihong Li,1,* Yuqian Li,1,* Feifei Xu,2,* Xi Zhang,3 Qiang Tian,4 Lihong

An Online Multisensor Data Fusion Framework for Radar Emitter Classification

Radar emitter classification is a special application of data clustering for classifying unknown radar emitters in airborne electronic support system. In this paper, a novel online multisensor data fusion framework is proposed for radar emitter classification under the background of network centric warfare. The framework is composed of local processing and multisensor fusion...

A blockade of PI3Kγ signaling effectively mitigates angiotensin II-induced renal injury and fibrosis in a mouse model

, Yunfeng Xia, Xi Zhang, Liqun Chen, Chen Zhao, Shifeng Huang, Jiayan Lei, Yixiao Feng, Wei Liu & Hua GanMolecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The ... for Xi Zhang in:Nature Research journals • PubMed • Google Scholar Search for Liqun Chen in:Nature Research journals • PubMed • Google Scholar Search for Shujuan Yan in:Nature Research journals