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Regioselective semi-synthesis of 6-isomers of 5,8-O-dimethyl ether of shikonin derivatives via an ‘intramolecular ring-closing/ring-opening’ strategy as potent anticancer agents

anticancer agents Li Zhou 2 Xu Zhang 1 Wen Zhou 0 0 School of Chinese Meteria Medica, Guangzhou University of Chinese Medicine, E. 232, University Town , Waihuan Rd, Panyu, Guangzhou 510006, Guangdong

Risk factors for postoperative haemorrhage after total thyroidectomy: clinical results based on 2,678 patients

the data availability. Author Contributions Xu Zhang, Qigen Fang and Wei Du wrote this paper, revised this paper, reviewed this paper and agreed with the submission. Additional Information Competing

Dexmedetomidine attenuates persistent postsurgical pain by upregulating K+–Cl− cotransporter-2 in the spinal dorsal horn in rats

Dexmedetomidine attenuates persistent postsurgical pain by upregulating K+-Cl- cotransporter-2 in the spinal dorsal horn in rats Shuhong Dai,1 Yu Qi,1 Jie Fu,1 Na Li,1 Xu Zhang,1 Juan Zhang,2 Wei

Suppressor of cytokine signalling-2 limits IGF1R-mediated regulation of epithelial–mesenchymal transition in lung adenocarcinoma

, Ning Wang, Xu Zhang, Li John Zhong & Qian WangState Key Lab of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, ChinaJizheng ChenState Key Laboratory of Natural ... journals • PubMed • Google Scholar Search for Xu Zhang in:Nature Research journals • PubMed • Google Scholar Search for Min Guo in:Nature Research journals • PubMed • Google Scholar Search for Li John

Clinical Characteristics of Aldosterone- and Cortisol-Coproducing Adrenal Adenoma in Primary Aldosteronism

, Air Force General Hospital, Beijing, China Correspondence should be addressed to Baojun Wang; moc.621@90004nujoab and Xu Zhang; nc.ude.umjt.hjt@gnahzx Received 11 December 2017; Accepted 30 January

Clinical Characteristics of Aldosterone- and Cortisol-Coproducing Adrenal Adenoma in Primary Aldosteronism

, Air Force General Hospital, Beijing, China Correspondence should be addressed to Baojun Wang; moc.621@90004nujoab and Xu Zhang; nc.ude.umjt.hjt@gnahzx Received 11 December 2017; Accepted 30 January

A Systematic Review about the Efficacy and Safety of Tripterygium wilfordii Hook.f. Preparations Used for the Management of Rheumatoid Arthritis

Li,3 Attilio Mucelli,4 Xu Zhang,5 and Xueping Zhou1 1The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, China 2School of Health Economics and Management ... , Nanjing University of Chinese Medicine, Nanjing 210023, China Correspondence should be addressed to Attilio Mucelli; moc.liamg@illecum.oilitta, Xu Zhang; nc.ude.mcujn@uxgnahz, and Xueping Zhou

Role of presurgical targeted molecular therapy in renal cell carcinoma with an inferior vena cava tumor thrombus

Role of presurgical targeted molecular therapy in renal cell carcinoma with an inferior vena cava tumor thrombus Cheng Peng,1,* Liangyou Gu,1,* Lei Wang,2 Qingbo Huang,1 Baojun Wang,1 Gang Guo,1 Yang Fan,1 Yu Gao,1 Xin Ma,1 Xu Zhang1 1Department of Urology, State Key Laboratory of Kidney Diseases, Chinese PLA General Hospital, Chinese PLA Medical Academy, Beijing, People’s...

Somatosensory Neuron Typing with High-Coverage Single-Cell RNA Sequencing and Functional Analysis

Different physical and chemical stimuli are detected by the peripheral sensory receptors of dorsal root ganglion (DRG) neurons, and the generated inputs are transmitted via afferent fibers into the central nervous system. The gene expression profiles of DRG neurons contribute to the generation, transmission, and regulation of various somatosensory signals. Recently, the single...

Analysis of Pressure Pulsation Induced by Rotor-Stator Interaction in Nuclear Reactor Coolant Pump

Lallart Copyright © 2017 Xu Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any

Analysis of Pressure Pulsation Induced by Rotor-Stator Interaction in Nuclear Reactor Coolant Pump

Lallart Copyright © 2017 Xu Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any

New insight into inter-organ crosstalk contributing to the pathogenesis of non-alcoholic fatty liver disease (NAFLD)

; VLDL, very low-density lipoprotein. COMPLIANCE WITH ETHICS GUIDELINES Xu Zhang, Xuetao Ji, Qian Wang, and John Zhong LI declare that they have no conflict of interest. This article does not contain any

MicroRNA-19a and microRNA-19b promote the malignancy of clear cell renal cell carcinoma through targeting the tumor suppressor RhoB

Conceptualization: Xufeng Chen, Xu Zhang. Data curation: Shaoxi Niu. Formal analysis: Shaoxi Niu. Funding acquisition: Xin Ma. Methodology: Yu Zhang. Project administration: Xu Zhang. Resources: Xu Zhang

Metaproteomics reveals associations between microbiome and intestinal extracellular vesicle proteins in pediatric inflammatory bowel disease

Alterations in gut microbiota have been implicated in the pathogenesis of inflammatory bowel disease (IBD), however factors that mediate the host–microbiota interactions remain largely unknown. Here we collected mucosal-luminal interface samples from a pediatric IBD inception cohort and characterized both the human and microbiota proteins using metaproteomics. We show that...

Circular RNAs: emerging cancer biomarkers and targets

CircRNAs are a class of RNA molecules that structurally form closed loops. CircRNAs are abundant in eukaryotic transcripts and show certain levels of tissue and cell specificity. CircRNAs have been suggested to regulate gene expression at transcriptional, post-transcriptional, and translational levels. An increasing number of studies have shown that circRNAs play important roles...

Human Umbilical Cord MSC-Derived Exosomes Suppress the Development of CCl4-Induced Liver Injury through Antioxidant Effect

Mesenchymal stem cells (MSCs) have been increasingly applied into clinical therapy. Exosomes are small (30–100 nm in diameter) membrane vesicles released by different cell types and possess the similar functions with their derived cells. Human umbilical cord MSC-derived exosomes (hucMSC-Ex) play important roles in liver repair. However, the effects and mechanisms of hucMSC-Ex on...