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De novo assembly of transcriptome from next-generation sequencing data

(Nos. 31571310 and 31271409). COMPLIANCE WITH ETHICS GUIDELINES The authors Xuan Li, Yimeng Kong, Qiong-Yi Zhao, Yuan-Yuan Li and Pei Hao declare they have no conflict of interests. This article does

The carboxypeptidase D homolog silver regulates memory formation via insulin pathway in Drosophila

. Z.), the Tsinghua-Peking Joint Center for Life Sciences and the Tsinghua University Initiative Scientific Research Program (20111080956, to Y. Z.). Binyan Lu, Yi Zhao, Jie Zhao, Xiaoyang Yao, Yichun

Association of Interleukin-23 receptor gene polymorphisms with susceptibility to Crohn’s disease: A meta-analysis

because of the analysis based on linkage considerations. Data extraction Data were collected by two independent investigators (Qi-Bing Xie and Yi Zhao). The characteristics of the selected articles were in ... Xu, Qi-Bing Xie, Yi Zhao & Yi Liu AuthorsSearch for Wang-Dong Xu in:Nature Research journals • PubMed • Google ScholarSearch for Qi-Bing Xie in:Nature Research journals • PubMed • Google ScholarSearch

Association of Plasma IL-32 Levels and Gene Polymorphisms with Systemic Lupus Erythematosus in Chinese Han Population

Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease. IL-32, a secreted protein, has been reported to be associated with several autoimmune diseases. Our preliminary experiment showed different plasma IL-32 levels than that mentioned in a published report on the same population. In order to elucidate the correlation between IL-32 and SLE, we determined the...

Cooperation or Competition: An Evolutionary Game Study between Commercial Banks and Big Data-Based E-Commerce Financial Institutions in China

2015; Accepted 30 January 2015 Academic Editor: Chuanxi Qian Copyright © 2015 Yi Zhao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits

Cooperation or Competition: An Evolutionary Game Study between Commercial Banks and Big Data-Based E-Commerce Financial Institutions in China

2015; Accepted 30 January 2015 Academic Editor: Chuanxi Qian Copyright © 2015 Yi Zhao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits

A programmable metasurface with dynamic polarization, scattering and focusing control

Diverse electromagnetic (EM) responses of a programmable metasurface with a relatively large scale have been investigated, where multiple functionalities are obtained on the same surface. The unit cell in the metasurface is integrated with one PIN diode, and thus a binary coded phase is realized for a single polarization. Exploiting this anisotropic characteristic, reconfigurable...

FUS-linked essential tremor associated with motor dysfunction in Drosophila

Essential tremor (ET) is one of the most common adult-onset neurological disorders which produce motor and non-motor symptoms. To date, there are no gold standard pathological hallmarks of ET, and despite a strong genetic contribution toward ET development, only a few pathogenic mutations have been identified. Recently, a pathogenic FUS-Q290X mutation has been reported in a large...

Si- and Ge-Based Electronic Devices

Institute of Standards & Technology, Washington, DC 20899, USA Received 26 March 2015; Accepted 26 March 2015 Copyright © 2015 Yi Zhao et al. This is an open access article distributed under the Creative ... , but also important solutions for the existing issues in the theory and fabrication of Si- and Ge-based electronic transistors. Yi Zhao Rui Zhang Jiwu Lu Wenfeng Zhang

Estimation of Saturation Flow Rate and Start-Up Lost Time for Signal Timing Based on Headway Distribution

210096, China Received 5 May 2015; Revised 31 July 2015; Accepted 2 August 2015 Academic Editor: Rigoberto Medina Copyright © 2015 Yi Zhao et al. This is an open access article distributed under the

Outer Synchronization of Complex Networks with Nondelayed and Time-Varying Delayed Couplings via Pinning Control or Impulsive Control

The outer synchronization problem between two complex networks with nondelayed and time-varying delayed couplings via two different control schemes, namely, pinning control and impulsive control, is considered. Firstly, by applying pinning control to a fraction of the network nodes and using a suitable Lyapunov function, we obtain some new and useful synchronization criteria...

Outer Synchronization of Complex Networks with Nondelayed and Time-Varying Delayed Couplings via Pinning Control or Impulsive Control

The outer synchronization problem between two complex networks with nondelayed and time-varying delayed couplings via two different control schemes, namely, pinning control and impulsive control, is considered. Firstly, by applying pinning control to a fraction of the network nodes and using a suitable Lyapunov function, we obtain some new and useful synchronization criteria...

NPInter v3.0: an upgraded database of noncoding RNA-associated interactions

Despite the fact that a large quantity of noncoding RNAs (ncRNAs) have been identified, their functions remain unclear. To enable researchers to have a better understanding of ncRNAs’ functions, we updated the NPInter database to version 3.0, which contains experimentally verified interactions between ncRNAs (excluding tRNAs and rRNAs), especially long noncoding RNAs (lncRNAs...

Targeting Th17 Cells with Small Molecules and Small Interference RNA

T helper 17 (Th17) cells play a central role in inflammatory and autoimmune diseases via the production of proinflammatory cytokines interleukin- (IL-) 17, IL-17F, and IL-22. Anti-IL-17 monoclonal antibodies show potent efficacy in psoriasis but poor effect in rheumatoid arthritis (RA) and Crohn’s disease. Alternative agents targeting Th17 cells may be a better way to inhibit the...

Targeting Th17 Cells with Small Molecules and Small Interference RNA

T helper 17 (Th17) cells play a central role in inflammatory and autoimmune diseases via the production of proinflammatory cytokines interleukin- (IL-) 17, IL-17F, and IL-22. Anti-IL-17 monoclonal antibodies show potent efficacy in psoriasis but poor effect in rheumatoid arthritis (RA) and Crohn’s disease. Alternative agents targeting Th17 cells may be a better way to inhibit the...

Impact of miRNA Sequence on miRNA Expression and Correlation between miRNA Expression and Cell Cycle Regulation in Breast Cancer Cells

The miRNAs regulate cell functions by inhibiting expression of proteins. Research on miRNAs had usually focused on identifying targets by base pairing between miRNAs and their targets. Instead of identifying targets, this paper proposed an innovative approach, namely impact significance analysis, to study the correlation between mature sequence, expression across patient samples...

Comprehensive Transcriptome Analyses of the Fructose-Fed Syrian Golden Hamster Liver Provides Novel Insights into Lipid Metabolism

Dyslipidemia has been widely proven to contribute to cardiovascular diseases and other metabolic disorders, especially in insulin resistance and type 2 diabetes. The overproduction of VLDL is a significant characteristic of dyslipidemia, indicating the dysfunction of hepatic lipid metabolism, from triglyceride synthesis to transport. The fructose-fed Syrian golden hamster is an...

10-Year experience regarding the reliability and morbidity of radio guided lymph node biopsy in penile cancer patients and the associated radiation exposure of medical staff in this procedure

Background The guidelines of the European Association of Urologists (EAU), of the German Society of Nuclear Medicine (DGN), and the European Society for Medical Oncology (ESMO) recommend sentinel lymph node biopsy (SLNB) for lymph node staging in penile cancer with non-palpable inguinal lymph nodes as one diagnostic method. Despite this, the method is neither widely nor regularly...

Modeling miRNA-mRNA interactions: fitting chemical kinetics equations to microarray data

Background The miRNAs are small non-coding RNAs of roughly 22 nucleotides in length, which can bind with and inhibit protein coding mRNAs through complementary base pairing. By degrading mRNAs and repressing proteins, miRNAs regulate the cell signaling and cell functions. This paper focuses on innovative mathematical techniques to model gene interactions by algorithmic analysis...

Identification and analysis of unitary loss of long-established protein-coding genes in Poaceae shows evidences for biased gene loss and putatively functional transcription of relics

Background Long-established protein-coding genes may lose their coding potential during evolution (“unitary gene loss”). Members of the Poaceae family are a major food source and represent an ideal model clade for plant evolution research. However, the global pattern of unitary gene loss in Poaceae genomes as well as the evolutionary fate of lost genes are still less-investigated...