Advanced search    

Search: authors:"Jie Wang"

617 papers found.
Use AND, OR, NOT, +word, -word, "long phrase", (parentheses) to fine-tune your search.

Dominant Negative Pathogenesis by Mutant Proinsulin in the Akita Diabetic Mouse

Tetsuro Izumi Hiromi Yokota-Hashimoto Shengli Zhao Jie Wang Philippe A. Halban Toshiyuki Takeuchi - sis in response to ER stress (10,11). Thus these findings indicate that the CHOP-dependent cell

Dynamic Changes in Subgraph Preference Profiles of Crucial Transcription Factors

Transcription factors with a large number of target genes—transcription hub(s), or THub(s)—are usually crucial components of the regulatory system of a cell, and the different patterns through which they transfer the transcriptional signal to downstream cascades are of great interest. By profiling normalized abundances (AN) of basic regulatory patterns of individual THubs in the...

Rapid urban malaria appraisal (RUMA) I: Epidemiology of urban malaria in Ouagadougou

Background Rapid urbanization in sub-Saharan Africa has a major impact on malaria epidemiology. While much is known about malaria in rural areas in Burkina Faso, the urban situation is less well understood. Methods An assessment of urban malaria was carried out in Ouagadougou in November -December, 2002 during which a rapid urban malaria appraisal (RUMA) was applied. Results The...

Association of CYP2D6 and CYP1A2 gene polymorphism with tardive dyskinesia in Chinese schizophrenic patients

Aim:To investigate the possible association of the CYP2D6 gene C100T polymorphism and the CYP1A2 gene C163A polymorphism with tardive dyskinesia (TD) in Chinese patients with schizophrenia.Methods:The recruited schizophrenic patients were assessed with the Abnormal Involuntary Movement Scale (AIMS), and divided into groups with TD (n=91) and without TD (n=91) according to the...

Identification of a differentially expressed gene, ACL, between Meishan × Large White and Large White × Meishan F1 hybrids and their parents

ATP-citrate lyase (ACL), one of the lipogenic enzymes, catalyses the formation of acetyl-coenzyme A (CoA) involved in the synthesis of fatty acid and cholesterol. In pig, very little is known about the ACL gene. In this work, the mRNA differential display technique was used to analyse the differences in gene expression between Meishan and Large White pigs and the F1 hybrids of...

Rapid urban malaria appraisal (RUMA) in sub-Saharan Africa

Background The rapid urban malaria appraisal (RUMA) methodology aims to provide a cost-effective tool to conduct rapid assessments of the malaria situation in urban sub-Saharan Africa and to improve the understanding of urban malaria epidemiology. Methods This work was done in Yopougon municipality (Abidjan), Cotonou, Dar es Salaam and Ouagadougou. The study design consists of...

NPInter: the noncoding RNAs and protein related biomacromolecules interaction database

The noncoding RNAs and protein related biomacromolecules interaction database (NPInter; http://bioinfo.ibp.ac.cn/NPInter or http://www.bioinfo.org.cn/NPInter) is a database that documents experimentally determined functional interactions between noncoding RNAs (ncRNAs) and protein related biomacromolecules (PRMs) (proteins, mRNAs or genomic DNAs). NPInter intends to provide the...

Escherichia coli: Development of Carbapenem Resistance During Therapy

A 76-year-old woman had recurrent urosepsis due to extended-spectrum β-lactamase-positive Escherichia coli. Imipenem resistance was detected after long-term imipenem-meropenem therapy. The carbapenem-hydrolyzing enzyme gene was identified as blaKPC-3. To our knowledge, this is the first documented case in which carbapenem-resistant E. coli emerged during therapy with imipenem and...

Development of an Exonuclease Protection Mediated PCR Bioassay for Sensitive Detection of Ah Receptor Agonists

The aromatic hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates many of the biological and toxicological effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) and related chemicals. Here we developed a novel method to detect the presence of AhR ligands using Exonuclease Protection Mediated PCR bioassay (EPM-PCR). This assay measures the...

Genome-wide association study identifies three novel loci for type 2 diabetes

Chen Peng Cheng Hu Ronald C. W. Ma Minako Imamura Minoru Iwata Tatsuhiko Tsunoda Takashi Morizono Nobuhiro Shojima Wing Yee So Ting Fan Leung Patrick Kwan Rong Zhang Jie Wang Weihui Yu Hiroshi Maegawa

Preoperative Proteinuria Is Associated with Long-Term Progression to Chronic Dialysis and Mortality after Coronary Artery Bypass Grafting Surgery

Acute Renal Failure (NSARF) includes: Wen-Je Ko, MD, PhD, Vin-Cent Wu, MD, YuFeng Lin, MD, Yih-Sharng Chen, MD, PhD, Yung-Ming Chen, MD, Chih-Chung Shiao, MD, Chun-Fu Lai, MD, Wei-Jie Wang, MD, PeiChen Wu

Enzymatic Degradation of Prion Protein in Brain Stem from Infected Cattle and Sheep

Prions—infectious agents involved in transmissible spongiform encephalopathies—normally survive proteolytic and mild protein-destructive processes. Using bacterial keratinase produced by Bacillus licheniformis strain PWD-1, we tested conditions to accomplish the full degradation of prion protein (PrP) in brain-stem tissue from animals with bovine spongiform encephalopathy and...

Expression of MRP14 gene is frequently down-regulated in Chinese human esophageal cancer

Migration inhibitory factor-related protein 14 (MRP14) is one of calcium-binding proteins, referred as S100A9. The heterodimeric molecule formed by MRP14 with its partner MRP8 (S100A8) is the major fatty acid carrier in neutrophils. The MRP8/14 complex has been also implicated in the intracellular transport of arachidonic acid and its precursors in keratinocytes. We show here the...

Novel magnetic/ultrasound focusing system enhances nanoparticle drug delivery for glioma treatment

Malignant glioma is a common and severe primary brain tumor with a high recurrence rate and an extremely high mortality rate within 2 years of diagnosis, even when surgical, radiological, and chemotherapeutic interventions are applied. Intravenously administered drugs have limited use because of their adverse systemic effects and poor blood–brain barrier penetration. Here, we...

Proteomic analysis of ubiquitin-proteasome effects: insight into the function of eukaryotic initiation factor 5A

, ChinaBao-Feng Jin, Kun He, Hong-Xia Wang, Jie Wang, Tao Zhou, Yu Lan, Mei-Ru Hu, Kai-Hua Wei, Song-Cheng Yang, Bei-Fen Shen & Xue-Min Zhang AuthorsSearch for Bao-Feng Jin in:Nature Research journals • PubMed ... • Google ScholarSearch for Kun He in:Nature Research journals • PubMed • Google ScholarSearch for Hong-Xia Wang in:Nature Research journals • PubMed • Google ScholarSearch for Jie Wang in:Nature Research

LAB-EXPERIMENTAL (PRE-CLINICAL) THERAPEUTICS AND PHARMACOLOGY

resistance to this combination treatment might involve expression change of both MGMT and MMR. ET-13. MICRORNA-181B IS ASSOCIATED WITH CHEMOSENSITIVITY AND MAY SERVE AS A PROGNOSTIC BIOMARKER IN GLIOMAS Jie ... Wang, Ke Sai, Fu-Rong Chen, and Zhong-Ping Chen; Sun Yat-Sen University Cancer Center, Guangzhou, China Recent studies have reported that microRNA-181b (miR-181b) functions as a tumor suppressor in