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62 papers found.
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Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans

Background Animal models are indispensable to understand the lipid metabolism and lipid metabolic diseases. Over the last decade, the nematode Caenorhabditis elegans has become a popular animal model for exploring the regulation of lipid metabolism, obesity, and obese-related diseases. However, the genomic and functional conservation of lipid metabolism from C. elegans to humans...

MicroRNA-29c-5p suppresses gallbladder carcinoma progression by directly targeting CPEB4 and inhibiting the MAPK pathway

-An Wang Fei Zhang Han-Bin Liang Huai-Feng Li Yuan-Yuan Ye Shan-Shan Xiang Hao Weng Xiang-Song Wu Mao-Lan Li Yun-Ping Hu Wei Lu Yi-Jian Zhang Jian Zhu Ping Dong Ying-Bin Liu Gallbladder cancer (GBC

MSH2 is required for cell proliferation, cell cycle control and cell invasiveness in colorectal cancer cells

We have investigated the role of MSH2, a mismatch repair gene in cell proliferation, cell cycle control and cell invasiveness in the SW480 human colorectal cancer cell line. RNAi-mediated inhibition of MSH2 expression was achieved using MSH2 shRNA lentiviral expression vectors. Effective knockdown of endogenous MSH2 expression was determined by real-time PCR analysis. The most...

Acoustic Illusion near Boundaries of Arbitrary Curved Geometry

, Nanjing 210093, P. R. ChinaWeiwei Kan, Bin Liang, Xuefeng Zhu, Ruiqi Li, Xinye Zou, Haodong Wu & Jianchun ChengKey Laboratory of Noise and Vibration Research, Institute of Acoustics, Chinese Academy of ... Sciences, Beijing 100190, P. R. ChinaWeiwei Kan, Bin Liang, Jun Yang & Jianchun Cheng AuthorsSearch for Weiwei Kan in:Nature Research journals • PubMed • Google ScholarSearch for Bin Liang in:Nature Research

The E545K mutation of PIK3CA promotes gallbladder carcinoma progression through enhanced binding to EGFR

Background Gallbladder carcinoma (GBC) is the most common malignancy of the bile duct and patients with GBC have extremely poor prognoses. PIK3CA, which encodes the phosphoinositide 3-kinase (PI3K) subunit p110α, is frequently mutated in many cancers, including GBC. The function of the E545K mutation in GBC is not fully understood. Methods E545K mutation was determined in human...

2-Deoxy-D-Glucose Treatment of Endothelial Cells Induces Autophagy by Reactive Oxygen Species-Mediated Activation of the AMP-Activated Protein Kinase

Autophagy is a cellular self-digestion process activated in response to stresses such as energy deprivation and oxidative stress. However, the mechanisms by which energy deprivation and oxidative stress trigger autophagy remain undefined. Here, we report that activation of AMP-activated protein kinase (AMPK) by mitochondria-derived reactive oxygen species (ROS) is required for...

Hepatic Parenchymal Changes following Transcatheter Embolization and Chemoembolization in a Rabbit Tumor Model

Objective To compare the effects of transcatheter arterial chemoembolization (TACE) with transcatheter arterial embolization (TAE) on liver function, hepatic damage, and hepatic fibrogenesis in a rabbit tumor model. Materials and Methods Thirty-nine New Zealand white rabbits implanted with VX2 tumors in the left liver lobes were randomly divided into three groups: TAE, TACE, and...

Activation of AMP-Activated Protein Kinase Is Required for Berberine-Induced Reduction of Atherosclerosis in Mice: The Role of Uncoupling Protein 2

Aims Berberine, a botanical alkaloid purified from Coptidis rhizoma, is reported to activate the AMP-activated protein kinase (AMPK). Whether AMPK is required for the protective effects of berberine in cardiovascular diseases remains unknown. This study was designed to determine whether AMPK is required for berberine-induced reduction of oxidative stress and atherosclerosis in...

The Role of Nuclear Receptor NHR-64 in Fat Storage Regulation in Caenorhabditis elegans

Nuclear hormone receptors (NHRs) play vital roles in the regulation of metabolism, reproduction, and development. We found that inactivation of a C. elegans HNF4 homologue nhr-64 by RNA interference (RNAi) suppresses low fat stores in stearoyl-CoA desaturase-deficient fat-6;fat-7 double mutants and sterol regulatory element binding protein (SREBP) sbp-1 mutants. Furthermore...

The Influence of Bacterial Diet on Fat Storage in C. elegans

Background The nematode Caenorhabditis elegans has emerged as an important model for studies of the regulation of fat storage. C. elegans feed on bacteria, and various strains of E. coli are commonly used in research settings. However, it is not known whether particular bacterial diets affect fat storage and metabolism. Methodology/Principal Findings Fat staining of fixed...

Effect of Transcatheter Intraarterial Therapies on the Distribution of Doxorubicin in Liver Cancer in a Rabbit Model

Background and Aims Transcatheter intraarterial techniques can effectively deliver chemotherapeutic agents to tumor and improve the efficacy of chemotherapy. The present study is designed to evaluate the effect of transcatheter intraarterial techniques on the distribution of doxorubicin in relation to blood vessels in liver cancer. Methods VX2 tumors were implanted in the livers...

Bovine HEXIM1 inhibits bovine immunodeficiency virus replication through regulating BTat-mediated transactivation

The bovine immunodeficiency virus (BIV) transactivator (BTat) recruits the bovine cyclin T1 (B-cyclin T1) to the LTR to facilitate the transcription of BIV. Here, we demonstrate that bovine hexamethylene bisacetamide (HMBA)-induced protein 1 (BHEXIM1) inhibits BTat-mediated BIV LTR transcription. The results of in vivo and in vitro assays show direct binding of BHEXIM1 to the B...

Simultaneous mineralization of CO2 and recovery of soluble potassium using earth-abundant potassium feldspar

CO2 capture and storage (CCS) is an important strategy in combatting anthropogenic climate change. However, commercial application of the CCS technique is currently hampered by its high energy expenditure and costs. To overcome this issue, CO2 capture and utilization (CCU) is a promising CO2 disposal method. We, for the first time, developed a promising method to mineralize CO2...

Clinical features and prognostic factors in patients with bone metastases from hepatocellular carcinoma after liver transplantation

Background Little is known about the clinical features and prognostic factors of bone metastases of hepatocellular carcinoma (HCC) following liver transplantation (LT). Methods All adult patients undergoing LT from 2001 to 2010 were reviewed. Patients with HCC bone metastases after LT received external beam radiotherapy(EBRT) during this period. Demographic variables, laboratory...

The Cortical and Striatal Gene Expression Profile of 100 Hz Electroacupuncture Treatment in 6-Hydroxydopamine-Induced Parkinson's Disease Model

Electroacupuncture (EA), especially high-frequency EA, has frequently been used as an alternative therapy for Parkinson disease (PD) and is reportedly effective for alleviating motor symptoms in patients and PD models. However, the molecular mechanism underlying its effectiveness is not completely understood. To implement a full-scale search for the targets of 100 Hz EA, we...

The Cortical and Striatal Gene Expression Profile of 100 Hz Electroacupuncture Treatment in 6-Hydroxydopamine-Induced Parkinson's Disease Model

Electroacupuncture (EA), especially high-frequency EA, has frequently been used as an alternative therapy for Parkinson disease (PD) and is reportedly effective for alleviating motor symptoms in patients and PD models. However, the molecular mechanism underlying its effectiveness is not completely understood. To implement a full-scale search for the targets of 100 Hz EA, we...

Amniotic-Fluid–Derived Mesenchymal Stem Cells Overexpressing Interleukin-1 Receptor Antagonist Improve Fulminant Hepatic Failure

Uncontrolled hepatic immunoactivation is regarded as the primary pathological mechanism of fulminant hepatic failure (FHF). The major acute-phase mediators associated with FHF, including IL-1β, IL-6, and TNF-α, impair the regeneration of liver cells and stem cell grafts. Amniotic-fluid–derived mesenchymal stem cells (AF-MSCs) have the capacity, under specific conditions, to...

Activation of AMP-Activated Protein Kinase Inhibits Oxidized LDL-Triggered Endoplasmic Reticulum Stress In Vivo

Yunzhou Dong Miao Zhang Shuangxi Wang Bin Liang Zhengxing Zhao Chao Liu Mingyuan Wu Hyoung Chul Choi Timothy J. Lyons Ming-Hui Zou OBJECTIVE-The oxidation of LDLs is considered a key step in the

Genome of the Chinese tree shrew

, Kunming Institute of Zoology, Kunming, Yunnan 650223, ChinaYu Fan, Ce-Shi Chen, Xin-Tian Hu, Ren Lai, Bin Liang, Dan Mu, Yuan-Ye Ma, Yu-Yu Niu, Lin Xu, Yun Zhang, Xu-Dong Zhao, Yong-Tang Zheng, Ju-Min Zhou ... Yong-Shan Lang in:Nature Research journals • PubMed • Google ScholarSearch for Bin Liang in:Nature Research journals • PubMed • Google ScholarSearch for Sheng-Guang Liao in:Nature Research journals