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A rare nonsynonymous variant in the lipid metabolic gene HELZ2 related to primary biliary cirrhosis in Chinese Han

Background Several genome-wide association studies of primary biliary cirrhosis (PBC) in European and Japanese origins have shown significant association of dozens of genetic loci contributive to the susceptibility of PBC. Most of the loci were related to immune response pathway. In this study, we tested whether the lipid metabolic gene HELZ2 was associated with the pathogenesis...

Specific immunotherapy ameliorates ulcerative colitis

Background Hypersensitivity reaction to certain allergens plays a role in the pathogenesis of inflammatory bowel disease (IBD). This study aims to observe the effect of specific immunotherapy in a group of IBD patients. Methods Patients with both ulcerative colitis (UC) and food allergy were recruited into this study. Food allergy was diagnosed by skin prick test and serum...

Human Papillomavirus Testing for Cervical Cancer Screening: Results From a 6-Year Prospective Study in Rural China

/Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, Peoples Republic of China (Ju-Fang Shi, Fang-Hui Zhao, Jing Li, Feng Chen, Wang Xiang, You-Lin Qiao); Department of

Community Structure and Biodiversity of Soil Ciliates at Dongzhaigang Mangrove Forest in Hainan Island, China

2009; Revised 7 March 2010; Accepted 30 March 2010 Academic Editor: Yongchao Liang Copyright © 2010 Jing Li et al. This is an open access article distributed under the Creative Commons Attribution ... vegetation restoration through their similarity indices. The soil ciliate community could be used to assess the restoration of the mangrove ecosystem. Acknowledgment Jing Li and Qingyu Liao contributed equally

Community Structure and Biodiversity of Soil Ciliates at Dongzhaigang Mangrove Forest in Hainan Island, China

November 2009; Revised 7 March 2010; Accepted 30 March 2010 Academic Editor: Yongchao Liang Copyright © 2010 Jing Li et al. This is an open access article distributed under the Creative Commons

Safety and tolerability of an anti-CD19 monoclonal antibody, MEDI-551, in subjects with systemic sclerosis: a phase I, randomized, placebo-controlled, escalating single-dose study

, escalating single-dose study Elena Schiopu 0 Soumya Chatterjee 2 Vivien Hsu 1 Armando Flor 6 Daniel Cimbora 6 Kaushik Patra 6 Wenliang Yao 6 Jing Li 5 Katie Streicher 6 Kathleen McKeever 4 6 Barbara White 3

Umbilical cord mesenchymal stem cell transplantation in active and refractory systemic lupus erythematosus: a multicenter clinical study

Introduction In our present single-center pilot study, umbilical cord (UC)–derived mesenchymal stem cells (MSCs) had a good safety profile and therapeutic effect in severe and refractory systemic lupus erythematosus (SLE). The present multicenter clinical trial was undertaken to assess the safety and efficacy of allogeneic UC MSC transplantation (MSCT) in patients with active and...

UDP-glucose dehydrogenase modulates proteoglycan synthesis in articular chondrocytes: its possible involvement and regulation in osteoarthritis

Introduction The objective of this study was to investigate the possible role of UDP-glucose dehydrogenase (UGDH) in osteoarthritis (OA) and uncover whether, furthermore how interleukin-1beta (IL-1β) affects UGDH gene expression. Methods UGDH specific siRNAs were applied to determine the role of UGDH in proteoglycan (PG) synthesis in human articular chondrocytes. Protein levels...

miR-146a, an IL-1β responsive miRNA, induces vascular endothelial growth factor and chondrocyte apoptosis by targeting Smad4

Introduction miR-146a is one of the first identified miRNAs expressed differentially in osteoarthritis (OA) cartilage. However, the role it plays in OA pathogenesis is not clear. The aim of this study is to identify a molecular target of miR-146a, thereby elucidating its function in chondrocytes during OA pathogenesis. Methods Primary chondrocytes from Sprague-Dawley rats were...

TNF/TNFR signal transduction pathway-mediated anti-apoptosis and anti-inflammatory effects of sodium ferulate on IL-1β-induced rat osteoarthritis chondrocytes in vitro

Introduction Sodium ferulate (SF) is a natural component of traditional Chinese herbs. Our previous study shows that SF has a protective effect on osteoarthritis (OA). The objective of this study was to investigate the effect of SF on the TNF/TNF receptor (TNFR) signal transduction pathway of rat OA chondrocytes. Methods Primary rat articular chondrocytes were co-treated with IL...

Intubation of non-difficult airways using video laryngoscope versus direct laryngoscope: a randomized, parallel-group study

The video laryngoscope is recommended for intubating difficult airways. The present study aimed to determine whether the video laryngoscope can further improve intubation success rates compared with the direct laryngoscope in patients with non-difficult airways. In total, 360 patients scheduled for elective abdominal surgeries were randomly assigned to undergo intubation using...

BSPAT: a fast online tool for DNA methylation co-occurrence pattern analysis based on high-throughput bisulfite sequencing data

Background Bisulfite sequencing is one of the most widely used technologies in analyzing DNA methylation patterns, which are important in understanding and characterizing the mechanism of DNA methylation and its functions in disease development. Efficient and user-friendly tools are critical in carrying out such analysis on high-throughput bisulfite sequencing data. However...

A new statistical approach to combining p-values using gamma distribution and its application to genome-wide association study

Background Combining information from different studies is an important and useful practice in bioinformatics, including genome-wide association study, rare variant data analysis and other set-based analyses. Many statistical methods have been proposed to combine p-values from independent studies. However, it is known that there is no uniformly most powerful test under all...

Evaluation and integration of existing methods for computational prediction of allergens

Background Allergy involves a series of complex reactions and factors that contribute to the development of the disease and triggering of the symptoms, including rhinitis, asthma, atopic eczema, skin sensitivity, even acute and fatal anaphylactic shock. Prediction and evaluation of the potential allergenicity is of importance for safety evaluation of foods and other environment...

Bellerophon: a hybrid method for detecting interchromo-somal rearrangements at base pair resolution using next-generation sequencing data

Matthew Hayes 0 Jing Li 0 0 Department of Electrical Engineering and Computer Science, Case Western Reserve University , 10900 Euclid Ave., Cleveland, OH , USA Background: Somatically-acquired

CASCADE_SCAN: mining signal transduction network from high-throughput data based on steepest descent method

Jing Li 0 Tieqiao Wen 0 0 Laboratory of Molecular Neurobiology, School of Life Sciences and Institute of Systems Biology, Shanghai University , Shanghai 200444 , China 1 Department of Mathematics

Accurate HLA type inference using a weighted similarity graph

Background The human leukocyte antigen system (HLA) contains many highly variable genes. HLA genes play an important role in the human immune system, and HLA gene matching is crucial for the success of human organ transplantations. Numerous studies have demonstrated that variation in HLA genes is associated with many autoimmune, inflammatory and infectious diseases. However...