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Hypercholesterolemic Myocardium Is Vulnerable to Ischemia-Reperfusion Injury and Refractory to Sevoflurane-Induced Protection

Recent studies have demonstrated that volatile anesthetic postconditioning confers myocardial protection against ischemia-reperfusion (IR) injury through activation of the reperfusion injury salvage kinase (RISK) pathway. As RISK has been shown to be impaired in hypercholesterolemia. Therefore, we investigate whether anesthetic-induced cardiac protection was maintained in...

Hyperinsulinemia shifted energy supply from glucose to ketone bodies in early nonalcoholic steatohepatitis from high-fat high-sucrose diet induced Bama minipigs

Sciences, No.2 Yuanmingyuan West Road, Beijing, 100193, P.R. ChinaShu-lin Yang, Ji-han Xia, Jing Yuan, Yu-lian Mu, Lei-lei Xin & Kui LiCollege of Veterinary Medicine, China Agricultural University, No.2 ... journals • PubMed • Google ScholarSearch for Qin Pan in:Nature Research journals • PubMed • Google ScholarSearch for Yu-lian Mu in:Nature Research journals • PubMed • Google ScholarSearch for Lei-lei Xin

ID1-induced p16/IL6 axis activation contributes to the resistant of hepatocellular carcinoma cells to sorafenib

Lei-lei Niu in:Nature Research journals • PubMed • Google Scholar Search for Chuan-le Cheng in:Nature Research journals • PubMed • Google Scholar Search for Ming-Yue Li in:Nature Research journals

Identification of a Novel Gene for Biosynthesis of a Bacteroid-Specific Electron Carrier Menaquinone

Ubiquinone (UQ) has been considered as an electron mediator in electron transfer that generates ATP in Rhizobium under both free-living and symbiosis conditions. When mutated, the dmtH gene has a symbiotic phenotype of forming ineffective nodules on Astragalus sinicus. The gene was isolated from a Mesorhizobium huakuii 7653R transposon-inserted mutant library. The DNA sequence...

Identification of a Novel Nuclear Localization Signal Sequence in Chlamydia trachomatis-Secreted Hypothetical Protein CT311

We previously reported that Chlamydia trachomatis hypothetical protein CT311 was secreted out of chlamydial inclusion and into host cell cytosol. We now found that CT311 further entered host cell nucleus at the late stage of infection and continued to accumulate in the nucleus of C. trachomatis-infected cells. When CT311 was expressed via a transgene in mammalian cells, CT311...

Impact of chromosomal heteromorphisms on reproductive failure and analysis of 38 heteromorphic pedigrees in Northeast China

Yuan Dong Yu-Ting Jiang Ri-Cheng Du Hong-Guo Zhang Lei-Lei Li Rui-Zhi Liu 0 ) Center for Reproductive Medicine, Center for Prenatal Diagnosis, First Hospital, Jilin University , Changchun 130021

Improved Surface Wettability of Water by Applying SiC/Ti6Al4V Coatings on Carbon/Carbon Composites

Copyright © 2013 Lei-Lei Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium

Increased microRNA-93-5p inhibits osteogenic differentiation by targeting bone morphogenetic protein-2

?token=clefscoqbpgxdid&;acc= GSE89587 (RAR) Author Contributions Data curation: Ying Zhang, Wei-Bin Ding, Lei-Lei Zhang, Hui-Chao Wang. Formal analysis: Ying Zhang. Funding acquisition: You-Wen Liu ... . Supervision: Ying Zhang. Writing ± original draft: Ying Zhang, Lei-Lei Zhang, Hui-Chao Wang, Ying-Jie Zhu, Yu-Na Chai, You-Wen Liu. Writing ± review & editing: Ying Zhang, Wei-Bin Ding, Lei-Lei Zhang, Hui

Induction of autophagy improves embryo viability in cloned mouse embryos

, ZhenDong Wang, GuangYu Bai, Zhong Zheng, YanLi Gu, YanShuang Wu, Hui Liu, DongJie Zhou & Lei Lei AuthorsSearch for XingHui Shen in:Nature Research journals • PubMed • Google ScholarSearch for Na Zhang ... • PubMed • Google ScholarSearch for Hui Liu in:Nature Research journals • PubMed • Google ScholarSearch for DongJie Zhou in:Nature Research journals • PubMed • Google ScholarSearch for Lei Lei in:Nature

Integrated analysis of transcriptome and proteome changes related to the Ogura cytoplasmic male sterility in cabbage

, California) for editing our manuscript. Author Contributions Conceptualization: Jungen Kang. Data curation: Miaomiao Xing, Chao Sun, Shilin Hu. Investigation: Shilin Hu, Lei Lei. Project administration

Intensity-dependent effect of treadmill running on lubricin metabolism of rat articular cartilage

Introduction We aimed to understand the changes in cartilage lubricin expression and immunolocalisation in responsed to treadmill running with different intensities in a rat model. Methods A total of 24 male Wistar rats were randomly assigned into groups of control (CON), low-intensity running (LIR), moderate-intensity running (MIR), and high-intensity running (HIR). Rats in LIR...

Left hemisphere predominance of pilocarpine-induced rat epileptiform discharges

Background The left cerebral hemisphere predominance in human focal epilepsy has been observed in a few studies, however, there is no related systematic study in epileptic animal on hemisphere predominance. The main goal of this paper is to observe if the epileptiform discharges (EDs) of Pilocarpine-induced epileptic rats could present difference between left hemisphere and right...

Matrix metalloproteinase-3 inhibitor retards treadmill running-induced cartilage degradation in rats

Introduction The effect of intra-articular injection of matrix metalloproteinase (MMP)-3 inhibitor was investigated in a rat model to understand the role of MMP-3 in cartilage degradation induced by excessive loading from running. Methods A total of 24 male Wistar rats were randomly assigned into groups of sedentary control (SED), high-intensity running (HIR), HIR + low dosage of...

Microbial synthesized biodegradable PHBHHxPEG hybrid copolymer as an efficient intracellular delivery nanocarrier for kinase inhibitor

Background Protein Kinases are key regulators of cell function and play essential roles in the occurrence and development of many human diseases. Many kinase inhibitors have been used for molecular targeted treatment of those diseases such as cancer and inflammation. However, those highly hydrophobic kinase inhibitors shared the common features of poor bioavailability and limited...

Microbial synthesized biodegradable PHBHHxPEG hybrid copolymer as an efficient intracellular delivery nanocarrier for kinase inhibitor

author, Ming-Chuan Li2, Xin-Liang Zhu1, Fan Fan1, Lei-Lei Wang1 and Jian-Gang Ma1 BMC Biotechnology201414:4 https://doi.org/10.1186/1472-6750-14-4 ©  Lu et al.; licensee BioMed Central Ltd. 2014

Mouse primordial germ cells produce cysts that partially fragment prior to meiosis

Lei Lei 0 Allan C. Spradling () 0 0 Howard Hughes Medical Institute Research Laboratories, Department of Embryology, Carnegie Institution of Washington , 3520 San Martin Drive, Baltimore, MD 21218

Nanoscale polysaccharide derivative as an AEG-1 siRNA carrier for effective osteosarcoma therapy

Nanoscale polysaccharide derivative as an AEG-1 siRNA carrier for effective osteosarcoma therapy Fen Wang,1,* Jia-Dong Pang,2,* Lei-lei Huang,1 Ran Wang,1 Dan Li,3 Kang Sun,4 Lian-tang Wang,1,* Li ... . 8 3 . 4 5 y b / m o c . s s e r p e v PowerdbyTCPDF(ww.tcpdf.org) O r I g I N a l r e s e a r c h lei-lei huang 1 ran Wang 1 Dan li 3 Kang sun 4 *These authors contributed equally to this work

Oviduct Infection and Hydrosalpinx in DBA1/j Mice Is Induced by Intracervical but Not Intravaginal Inoculation with Chlamydia muridarum

Intravaginal infection with C. muridarum in mice often results in hydrosalpinx similar to that found in women urogenitally infected with C. trachomatis, making the C. muridarum lower genital tract infection murine model suitable for studying C. trachomatis pathogenesis. To our surprise, DBA1/j mice were highly resistant to hydrosalpinx following an intravaginal infection with C...

PRDM16 functions as a suppressor of lung adenocarcinoma metastasis

The transcription factor PR domain containing 16 (PRDM16) is known to play a significant role in the determination and function of brown and beige fat. However, the role of PRDM16 in tumor biology has not been well addressed. Here we investigated the impact of PRDM16 on tumor growth and metastasis in lung cancer. UALCAN database, immunoblotting and immunohistochemistry analysis...